Folate mediated targeted delivery of cinnamaldehyde loaded and FITC functionalized magnetic nanoparticles in breast cancer: in vitro , in vivo and pharmacokinetic studies
In the present study, cinnamaldehyde (CNAD) was loaded onto magnetic (Fe 3 O 4 ) nanoparticles (NPs) that were functionalized with FITC and folic acid (FiCF NPs) for imaging and active drug targeting in breast cancer cells. The particle size of the NPs was ∼10 nm while TGA analysis revealed 20% load...
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| Veröffentlicht in: | New journal of chemistry 2021-01, Vol.45 (3), p.1500-1515 |
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| creator | Shetty, Varsha Jakhade, Alok Shinde, Kavita Chikate, Rajeev Kaul-Ghanekar, Ruchika |
| description | In the present study, cinnamaldehyde (CNAD) was loaded onto magnetic (Fe 3 O 4 ) nanoparticles (NPs) that were functionalized with FITC and folic acid (FiCF NPs) for imaging and active drug targeting in breast cancer cells. The particle size of the NPs was ∼10 nm while TGA analysis revealed 20% loading of CNAD onto the NPs. Folic acid conjugation resulted in an increased uptake of NPs in breast cancer cells with their localization in both the cytoplasm and the nucleus. FiCF NPs induced apoptosis in the cells and increased the expression of generic caspases. Acute toxicity study demonstrated safety of the NPs in Swiss albino mice. Interestingly, FiCF NPs reduced the tumor burden in the mouse breast cancer model compared to those treated with free CNAD and FiC functionalized NPs. Furthermore, pharmacokinetic studies in Wistar rats revealed prolonged circulation time and slower plasma elimination of CNAD in animals treated with FiCF NPs. Thus, FiCF NPs exhibited promising potential against breast cancer and warrant further safety studies in the future before exploring their potential at the clinical level. |
| doi_str_mv | 10.1039/D0NJ04319B |
| format | Article |
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The particle size of the NPs was ∼10 nm while TGA analysis revealed 20% loading of CNAD onto the NPs. Folic acid conjugation resulted in an increased uptake of NPs in breast cancer cells with their localization in both the cytoplasm and the nucleus. FiCF NPs induced apoptosis in the cells and increased the expression of generic caspases. Acute toxicity study demonstrated safety of the NPs in Swiss albino mice. Interestingly, FiCF NPs reduced the tumor burden in the mouse breast cancer model compared to those treated with free CNAD and FiC functionalized NPs. Furthermore, pharmacokinetic studies in Wistar rats revealed prolonged circulation time and slower plasma elimination of CNAD in animals treated with FiCF NPs. Thus, FiCF NPs exhibited promising potential against breast cancer and warrant further safety studies in the future before exploring their potential at the clinical level.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/D0NJ04319B</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Apoptosis ; Biocompatibility ; Breast cancer ; Cinnamaldehyde ; Conjugation ; Cytoplasm ; Folic acid ; In vivo methods and tests ; Iron oxides ; Nanoparticles ; Pharmacokinetics ; Pharmacology ; Safety ; Toxicity</subject><ispartof>New journal of chemistry, 2021-01, Vol.45 (3), p.1500-1515</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c259t-15d5a1ecd20498a4d753ee74d79cdc820ecab3ea7497d5bb14c996f0e0476a63</citedby><cites>FETCH-LOGICAL-c259t-15d5a1ecd20498a4d753ee74d79cdc820ecab3ea7497d5bb14c996f0e0476a63</cites><orcidid>0000-0003-1542-1038 ; 0000-0002-6312-0582</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids></links><search><creatorcontrib>Shetty, Varsha</creatorcontrib><creatorcontrib>Jakhade, Alok</creatorcontrib><creatorcontrib>Shinde, Kavita</creatorcontrib><creatorcontrib>Chikate, Rajeev</creatorcontrib><creatorcontrib>Kaul-Ghanekar, Ruchika</creatorcontrib><title>Folate mediated targeted delivery of cinnamaldehyde loaded and FITC functionalized magnetic nanoparticles in breast cancer: in vitro , in vivo and pharmacokinetic studies</title><title>New journal of chemistry</title><description>In the present study, cinnamaldehyde (CNAD) was loaded onto magnetic (Fe 3 O 4 ) nanoparticles (NPs) that were functionalized with FITC and folic acid (FiCF NPs) for imaging and active drug targeting in breast cancer cells. The particle size of the NPs was ∼10 nm while TGA analysis revealed 20% loading of CNAD onto the NPs. Folic acid conjugation resulted in an increased uptake of NPs in breast cancer cells with their localization in both the cytoplasm and the nucleus. FiCF NPs induced apoptosis in the cells and increased the expression of generic caspases. Acute toxicity study demonstrated safety of the NPs in Swiss albino mice. Interestingly, FiCF NPs reduced the tumor burden in the mouse breast cancer model compared to those treated with free CNAD and FiC functionalized NPs. Furthermore, pharmacokinetic studies in Wistar rats revealed prolonged circulation time and slower plasma elimination of CNAD in animals treated with FiCF NPs. Thus, FiCF NPs exhibited promising potential against breast cancer and warrant further safety studies in the future before exploring their potential at the clinical level.</description><subject>Apoptosis</subject><subject>Biocompatibility</subject><subject>Breast cancer</subject><subject>Cinnamaldehyde</subject><subject>Conjugation</subject><subject>Cytoplasm</subject><subject>Folic acid</subject><subject>In vivo methods and tests</subject><subject>Iron oxides</subject><subject>Nanoparticles</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Safety</subject><subject>Toxicity</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpFkc1KAzEUhYMoWKsbnyDgThxNZjIzjTut1h-KbrofbpM7bepMUpNMoT6ST-nUCq7Ox-HwweUScs7ZNWeZvHlgb69MZFzeH5ABzwqZyLTghz1zIRKWi-KYnISwYozzsuAD8j1xDUSkLWrTp6YR_AJ3oLExG_Rb6mqqjLXQQqNxudVIGwe6X4DVdPIyG9O6syoaZ6ExX33fwsJiNIpasG4NvscGAzWWzj1CiFSBVehvd83GRO_o1R437te5XoJvQbkPs9eE2GmD4ZQc1dAEPPvLIZlNHmfj52T6_vQyvpsmKs1lTHiuc-CodMqEHIHQZZ4hln1KpdUoZahgniGUQpY6n8-5UFIWNUMmygKKbEgu9tq1d58dhlitXOf720KVihHL-CjtjUNyuV8p70LwWFdrb1rw24qzaveK6v8V2Q9yL38z</recordid><startdate>20210121</startdate><enddate>20210121</enddate><creator>Shetty, Varsha</creator><creator>Jakhade, Alok</creator><creator>Shinde, Kavita</creator><creator>Chikate, Rajeev</creator><creator>Kaul-Ghanekar, Ruchika</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope><orcidid>https://orcid.org/0000-0003-1542-1038</orcidid><orcidid>https://orcid.org/0000-0002-6312-0582</orcidid></search><sort><creationdate>20210121</creationdate><title>Folate mediated targeted delivery of cinnamaldehyde loaded and FITC functionalized magnetic nanoparticles in breast cancer: in vitro , in vivo and pharmacokinetic studies</title><author>Shetty, Varsha ; Jakhade, Alok ; Shinde, Kavita ; Chikate, Rajeev ; Kaul-Ghanekar, Ruchika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c259t-15d5a1ecd20498a4d753ee74d79cdc820ecab3ea7497d5bb14c996f0e0476a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Apoptosis</topic><topic>Biocompatibility</topic><topic>Breast cancer</topic><topic>Cinnamaldehyde</topic><topic>Conjugation</topic><topic>Cytoplasm</topic><topic>Folic acid</topic><topic>In vivo methods and tests</topic><topic>Iron oxides</topic><topic>Nanoparticles</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Safety</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shetty, Varsha</creatorcontrib><creatorcontrib>Jakhade, Alok</creatorcontrib><creatorcontrib>Shinde, Kavita</creatorcontrib><creatorcontrib>Chikate, Rajeev</creatorcontrib><creatorcontrib>Kaul-Ghanekar, Ruchika</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shetty, Varsha</au><au>Jakhade, Alok</au><au>Shinde, Kavita</au><au>Chikate, Rajeev</au><au>Kaul-Ghanekar, Ruchika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Folate mediated targeted delivery of cinnamaldehyde loaded and FITC functionalized magnetic nanoparticles in breast cancer: in vitro , in vivo and pharmacokinetic studies</atitle><jtitle>New journal of chemistry</jtitle><date>2021-01-21</date><risdate>2021</risdate><volume>45</volume><issue>3</issue><spage>1500</spage><epage>1515</epage><pages>1500-1515</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>In the present study, cinnamaldehyde (CNAD) was loaded onto magnetic (Fe 3 O 4 ) nanoparticles (NPs) that were functionalized with FITC and folic acid (FiCF NPs) for imaging and active drug targeting in breast cancer cells. The particle size of the NPs was ∼10 nm while TGA analysis revealed 20% loading of CNAD onto the NPs. Folic acid conjugation resulted in an increased uptake of NPs in breast cancer cells with their localization in both the cytoplasm and the nucleus. FiCF NPs induced apoptosis in the cells and increased the expression of generic caspases. Acute toxicity study demonstrated safety of the NPs in Swiss albino mice. Interestingly, FiCF NPs reduced the tumor burden in the mouse breast cancer model compared to those treated with free CNAD and FiC functionalized NPs. Furthermore, pharmacokinetic studies in Wistar rats revealed prolonged circulation time and slower plasma elimination of CNAD in animals treated with FiCF NPs. Thus, FiCF NPs exhibited promising potential against breast cancer and warrant further safety studies in the future before exploring their potential at the clinical level.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/D0NJ04319B</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-1542-1038</orcidid><orcidid>https://orcid.org/0000-0002-6312-0582</orcidid></addata></record> |
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| ispartof | New journal of chemistry, 2021-01, Vol.45 (3), p.1500-1515 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Apoptosis Biocompatibility Breast cancer Cinnamaldehyde Conjugation Cytoplasm Folic acid In vivo methods and tests Iron oxides Nanoparticles Pharmacokinetics Pharmacology Safety Toxicity |
| title | Folate mediated targeted delivery of cinnamaldehyde loaded and FITC functionalized magnetic nanoparticles in breast cancer: in vitro , in vivo and pharmacokinetic studies |
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