Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response
Biomaterial science increasingly seeks more biomimetic scaffolds that functionally augment the native bone tissue. In this paper, a new concept of a structural scaffold design is presented where the physiological multi-scale architecture is fully incorporated in a single-scaffold solution. Hydroxyap...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2021, Vol.32 (1), p.3-3, Article 3 |
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| creator | Panseri, Silvia Montesi, Monica Hautcoeur, Dominique Dozio, Samuele M. Chamary, Shaan De Barra, Eamonn Tampieri, Anna Leriche, Anne |
| description | Biomaterial science increasingly seeks more biomimetic scaffolds that functionally augment the native bone tissue. In this paper, a new concept of a structural scaffold design is presented where the physiological multi-scale architecture is fully incorporated in a single-scaffold solution. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bioceramic scaffolds with different bioinspired porosity, mimicking the spongy and cortical bone tissue, were studied. In vitro experiments, looking at the mesenchymal stem cells behaviour, were conducted in a perfusion bioreactor that mimics the physiological conditions in terms of interstitial fluid flow and associated induced shear stress. All the biomaterials enhanced cell adhesion and cell viability. Cortical bone scaffolds, with an aligned architecture, induced an overexpression of several late stage genes involved in the process of osteogenic differentiation compared to the spongy bone scaffolds. This study reveals the exciting prospect of bioinspired porous designed ceramic scaffolds that combines both cortical and cancellous bone in a single ceramic bone graft. It is prospected that dual core shell scaffold could significantly modulate osteogenic processes, once implanted in patients, rapidly forming mature bone tissue at the tissue interface, followed by subsequent bone maturation in the inner spongy structure. |
| doi_str_mv | 10.1007/s10856-020-06486-3 |
| format | Article |
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In this paper, a new concept of a structural scaffold design is presented where the physiological multi-scale architecture is fully incorporated in a single-scaffold solution. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bioceramic scaffolds with different bioinspired porosity, mimicking the spongy and cortical bone tissue, were studied. In vitro experiments, looking at the mesenchymal stem cells behaviour, were conducted in a perfusion bioreactor that mimics the physiological conditions in terms of interstitial fluid flow and associated induced shear stress. All the biomaterials enhanced cell adhesion and cell viability. Cortical bone scaffolds, with an aligned architecture, induced an overexpression of several late stage genes involved in the process of osteogenic differentiation compared to the spongy bone scaffolds. This study reveals the exciting prospect of bioinspired porous designed ceramic scaffolds that combines both cortical and cancellous bone in a single ceramic bone graft. It is prospected that dual core shell scaffold could significantly modulate osteogenic processes, once implanted in patients, rapidly forming mature bone tissue at the tissue interface, followed by subsequent bone maturation in the inner spongy structure.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-020-06486-3</identifier><identifier>PMID: 33471246</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bioceramics ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Biomimetics ; Bioreactors ; Bone biomaterials ; Bone grafts ; Bones ; Calcium phosphates ; Cancellous bone ; Cell adhesion ; Cell adhesion & migration ; Cell viability ; Ceramics ; Chemical Sciences ; Chemistry and Materials Science ; Composites ; Cortical bone ; Differentiation (biology) ; Engineering Sciences ; Fluid dynamics ; Fluid flow ; Glass ; Grafting ; Hydroxyapatite ; Life Sciences ; Materials Science ; Mesenchyme ; Mimicry ; Natural Materials ; Perfusion ; Physiology ; Polymer Sciences ; Porosity ; Regenerative Medicine/Tissue Engineering ; Scaffolds ; Shear stress ; Stem cells ; Substitute bone ; Surfaces and Interfaces ; Surgical implants ; Thin Films ; Tissue Engineering Constructs and Cell Substrates ; Tissues ; Tricalcium phosphate</subject><ispartof>Journal of materials science. 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Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Biomaterial science increasingly seeks more biomimetic scaffolds that functionally augment the native bone tissue. In this paper, a new concept of a structural scaffold design is presented where the physiological multi-scale architecture is fully incorporated in a single-scaffold solution. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bioceramic scaffolds with different bioinspired porosity, mimicking the spongy and cortical bone tissue, were studied. In vitro experiments, looking at the mesenchymal stem cells behaviour, were conducted in a perfusion bioreactor that mimics the physiological conditions in terms of interstitial fluid flow and associated induced shear stress. All the biomaterials enhanced cell adhesion and cell viability. Cortical bone scaffolds, with an aligned architecture, induced an overexpression of several late stage genes involved in the process of osteogenic differentiation compared to the spongy bone scaffolds. This study reveals the exciting prospect of bioinspired porous designed ceramic scaffolds that combines both cortical and cancellous bone in a single ceramic bone graft. It is prospected that dual core shell scaffold could significantly modulate osteogenic processes, once implanted in patients, rapidly forming mature bone tissue at the tissue interface, followed by subsequent bone maturation in the inner spongy structure.</description><subject>Bioceramics</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Biomimetics</subject><subject>Bioreactors</subject><subject>Bone biomaterials</subject><subject>Bone grafts</subject><subject>Bones</subject><subject>Calcium phosphates</subject><subject>Cancellous bone</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell viability</subject><subject>Ceramics</subject><subject>Chemical Sciences</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Cortical bone</subject><subject>Differentiation (biology)</subject><subject>Engineering 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ceramic scaffolds designed with bioinspired porosity induce a different stem cell response</title><author>Panseri, Silvia ; Montesi, Monica ; Hautcoeur, Dominique ; Dozio, Samuele M. ; Chamary, Shaan ; De Barra, Eamonn ; Tampieri, Anna ; Leriche, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-c53d551a2f16c8538da91ded68c0e72e9d415de32f6262bc7c527059e3f6567b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bioceramics</topic><topic>Biomaterials</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedical materials</topic><topic>Biomimetics</topic><topic>Bioreactors</topic><topic>Bone biomaterials</topic><topic>Bone grafts</topic><topic>Bones</topic><topic>Calcium phosphates</topic><topic>Cancellous bone</topic><topic>Cell adhesion</topic><topic>Cell adhesion & migration</topic><topic>Cell 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panseri, Silvia</au><au>Montesi, Monica</au><au>Hautcoeur, Dominique</au><au>Dozio, Samuele M.</au><au>Chamary, Shaan</au><au>De Barra, Eamonn</au><au>Tampieri, Anna</au><au>Leriche, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2021</date><risdate>2021</risdate><volume>32</volume><issue>1</issue><spage>3</spage><epage>3</epage><pages>3-3</pages><artnum>3</artnum><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Biomaterial science increasingly seeks more biomimetic scaffolds that functionally augment the native bone tissue. In this paper, a new concept of a structural scaffold design is presented where the physiological multi-scale architecture is fully incorporated in a single-scaffold solution. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bioceramic scaffolds with different bioinspired porosity, mimicking the spongy and cortical bone tissue, were studied. In vitro experiments, looking at the mesenchymal stem cells behaviour, were conducted in a perfusion bioreactor that mimics the physiological conditions in terms of interstitial fluid flow and associated induced shear stress. All the biomaterials enhanced cell adhesion and cell viability. Cortical bone scaffolds, with an aligned architecture, induced an overexpression of several late stage genes involved in the process of osteogenic differentiation compared to the spongy bone scaffolds. This study reveals the exciting prospect of bioinspired porous designed ceramic scaffolds that combines both cortical and cancellous bone in a single ceramic bone graft. It is prospected that dual core shell scaffold could significantly modulate osteogenic processes, once implanted in patients, rapidly forming mature bone tissue at the tissue interface, followed by subsequent bone maturation in the inner spongy structure.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33471246</pmid><doi>10.1007/s10856-020-06486-3</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-8099-7132</orcidid><orcidid>https://orcid.org/0000-0002-2801-2957</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of materials science. Materials in medicine, 2021, Vol.32 (1), p.3-3, Article 3 |
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| source | Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Springer Nature OA Free Journals |
| subjects | Bioceramics Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Biomimetics Bioreactors Bone biomaterials Bone grafts Bones Calcium phosphates Cancellous bone Cell adhesion Cell adhesion & migration Cell viability Ceramics Chemical Sciences Chemistry and Materials Science Composites Cortical bone Differentiation (biology) Engineering Sciences Fluid dynamics Fluid flow Glass Grafting Hydroxyapatite Life Sciences Materials Science Mesenchyme Mimicry Natural Materials Perfusion Physiology Polymer Sciences Porosity Regenerative Medicine/Tissue Engineering Scaffolds Shear stress Stem cells Substitute bone Surfaces and Interfaces Surgical implants Thin Films Tissue Engineering Constructs and Cell Substrates Tissues Tricalcium phosphate |
| title | Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response |
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