Paracoccidioides brasiliensis Isolated from Nine-Banded Armadillos ( Dasypus novemcinctus ) Reveal Population Structure and Admixture in the Amazon Basin
Paracoccidioidomycosis is an endemic fungal disease to Latin America caused by at least five species-level genotypes of , named , (S1a and S1b populations), , , and . In this manuscript, we report on sp. sampling efforts in armadillos from two different areas in Brazil. We sequenced the genomes of s...
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| Veröffentlicht in: | Journal of fungi (Basel) 2021-01, Vol.7 (1), p.54 |
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| creator | Bagagli, Eduardo Matute, Daniel Ricardo Garces, Hans Garcia Tenório, Bernardo Guerra Garces, Adalberto Garcia Alves, Lucas Gomes de Brito Yamauchi, Danielle Hamae Hrycyk, Marluce Francisca Barker, Bridget Marie Teixeira, Marcus de Melo |
| description | Paracoccidioidomycosis is an endemic fungal disease to Latin America caused by at least five species-level genotypes of
, named
,
(S1a and S1b populations),
,
, and
. In this manuscript, we report on
sp. sampling efforts in armadillos from two different areas in Brazil. We sequenced the genomes of seven
isolates and used phylogenomics and populations genetics for genotyping. We found that
and
are both present in the Amazon region. Additionally, we identified two
isolates that seem to be the result of admixture between divergent populations within
sensu stricto. Both of these isolates were recovered from armadillos in a
endemic area in Midwestern Brazil. Additionally, two isolates from human patients also show evidence of resulting from admixture. Our results suggest that the populations of
sensu stricto exchange genes in nature. More generally, they suggest that population structure and admixture within species is an important source of variation for pathogenic fungi. |
| doi_str_mv | 10.3390/jof7010054 |
| format | Article |
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, named
,
(S1a and S1b populations),
,
, and
. In this manuscript, we report on
sp. sampling efforts in armadillos from two different areas in Brazil. We sequenced the genomes of seven
isolates and used phylogenomics and populations genetics for genotyping. We found that
and
are both present in the Amazon region. Additionally, we identified two
isolates that seem to be the result of admixture between divergent populations within
sensu stricto. Both of these isolates were recovered from armadillos in a
endemic area in Midwestern Brazil. Additionally, two isolates from human patients also show evidence of resulting from admixture. Our results suggest that the populations of
sensu stricto exchange genes in nature. More generally, they suggest that population structure and admixture within species is an important source of variation for pathogenic fungi.</description><identifier>ISSN: 2309-608X</identifier><identifier>EISSN: 2309-608X</identifier><identifier>DOI: 10.3390/jof7010054</identifier><identifier>PMID: 33467393</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>admixture ; Amazon ; armadillos ; Deoxyribonucleic acid ; Divergence ; DNA ; Fungi ; Genomes ; Genotypes ; Genotyping ; Laboratory animals ; Paracoccidioides ; paracoccidioidomycosis ; Pathogens ; Phylogenetics ; Population genetics ; Population structure ; Principal components analysis ; South American blastomycosis</subject><ispartof>Journal of fungi (Basel), 2021-01, Vol.7 (1), p.54</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-203ed1ce8322bcb99a305ec8b058b60b9fdcd4978c442755e500c1bce92c33093</citedby><cites>FETCH-LOGICAL-c472t-203ed1ce8322bcb99a305ec8b058b60b9fdcd4978c442755e500c1bce92c33093</cites><orcidid>0000-0002-7501-3362 ; 0000-0002-8003-4109 ; 0000-0002-6100-3534 ; 0000-0002-3439-4517 ; 0000-0003-1763-3464 ; 0000-0001-8932-3954</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829815/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829815/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33467393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bagagli, Eduardo</creatorcontrib><creatorcontrib>Matute, Daniel Ricardo</creatorcontrib><creatorcontrib>Garces, Hans Garcia</creatorcontrib><creatorcontrib>Tenório, Bernardo Guerra</creatorcontrib><creatorcontrib>Garces, Adalberto Garcia</creatorcontrib><creatorcontrib>Alves, Lucas Gomes de Brito</creatorcontrib><creatorcontrib>Yamauchi, Danielle Hamae</creatorcontrib><creatorcontrib>Hrycyk, Marluce Francisca</creatorcontrib><creatorcontrib>Barker, Bridget Marie</creatorcontrib><creatorcontrib>Teixeira, Marcus de Melo</creatorcontrib><title>Paracoccidioides brasiliensis Isolated from Nine-Banded Armadillos ( Dasypus novemcinctus ) Reveal Population Structure and Admixture in the Amazon Basin</title><title>Journal of fungi (Basel)</title><addtitle>J Fungi (Basel)</addtitle><description>Paracoccidioidomycosis is an endemic fungal disease to Latin America caused by at least five species-level genotypes of
, named
,
(S1a and S1b populations),
,
, and
. In this manuscript, we report on
sp. sampling efforts in armadillos from two different areas in Brazil. We sequenced the genomes of seven
isolates and used phylogenomics and populations genetics for genotyping. We found that
and
are both present in the Amazon region. Additionally, we identified two
isolates that seem to be the result of admixture between divergent populations within
sensu stricto. Both of these isolates were recovered from armadillos in a
endemic area in Midwestern Brazil. Additionally, two isolates from human patients also show evidence of resulting from admixture. Our results suggest that the populations of
sensu stricto exchange genes in nature. More generally, they suggest that population structure and admixture within species is an important source of variation for pathogenic fungi.</description><subject>admixture</subject><subject>Amazon</subject><subject>armadillos</subject><subject>Deoxyribonucleic acid</subject><subject>Divergence</subject><subject>DNA</subject><subject>Fungi</subject><subject>Genomes</subject><subject>Genotypes</subject><subject>Genotyping</subject><subject>Laboratory animals</subject><subject>Paracoccidioides</subject><subject>paracoccidioidomycosis</subject><subject>Pathogens</subject><subject>Phylogenetics</subject><subject>Population genetics</subject><subject>Population structure</subject><subject>Principal components analysis</subject><subject>South American blastomycosis</subject><issn>2309-608X</issn><issn>2309-608X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNpdkl1rFTEQhhdRbKm98QdIwJsqHJ187G5yI5zWrwNFix_gXcgms20Ou8kx2S3Wf-K_NZ5Ta-tVMjMPDy_DVNVjCi84V_ByHfsWKEAt7lX7jINaNCC_3b_136sOc14DAK1loxR_WO1xLpqWK75f_TozydhorXc-eoeZdMlkP3gM2WeyynEwEzrSpziSDz7g4tgEVxrLNBrnhyFmckRem3y1mTMJ8RJH64OdSvGMfMJLNAM5i5u5WHwM5POU5jJMSIqFLN3of2wrH8h0gWQ5mp-FOi4JwqPqQW-GjIfX70H19e2bLyfvF6cf361OlqcLK1o2LRhwdNSi5Ix1tlPKcKjRyg5q2TXQqd5ZJ1QrrRCsrWusASztLCpmeVkRP6hWO6-LZq03yY8mXelovN42YjrXJk3eDqih7y2TTfEAFVSC6eq-rV2vWN80nLbF9Wrn2szdiM5imJIZ7kjvToK_0OfxUreSKUnrIji6FqT4fcY86dFni8NgAsY5ayZaJaiSghf06X_oOs4plFVtKcqUEFCo5zvKpphzwv4mDAX954D0vwMq8JPb8W_Qv-fCfwMavcLN</recordid><startdate>20210115</startdate><enddate>20210115</enddate><creator>Bagagli, Eduardo</creator><creator>Matute, Daniel Ricardo</creator><creator>Garces, Hans Garcia</creator><creator>Tenório, Bernardo Guerra</creator><creator>Garces, Adalberto Garcia</creator><creator>Alves, Lucas Gomes de Brito</creator><creator>Yamauchi, Danielle Hamae</creator><creator>Hrycyk, Marluce Francisca</creator><creator>Barker, Bridget Marie</creator><creator>Teixeira, Marcus de Melo</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7501-3362</orcidid><orcidid>https://orcid.org/0000-0002-8003-4109</orcidid><orcidid>https://orcid.org/0000-0002-6100-3534</orcidid><orcidid>https://orcid.org/0000-0002-3439-4517</orcidid><orcidid>https://orcid.org/0000-0003-1763-3464</orcidid><orcidid>https://orcid.org/0000-0001-8932-3954</orcidid></search><sort><creationdate>20210115</creationdate><title>Paracoccidioides brasiliensis Isolated from Nine-Banded Armadillos ( Dasypus novemcinctus ) Reveal Population Structure and Admixture in the Amazon Basin</title><author>Bagagli, Eduardo ; Matute, Daniel Ricardo ; Garces, Hans Garcia ; Tenório, Bernardo Guerra ; Garces, Adalberto Garcia ; Alves, Lucas Gomes de Brito ; Yamauchi, Danielle Hamae ; Hrycyk, Marluce Francisca ; Barker, Bridget Marie ; Teixeira, Marcus de Melo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-203ed1ce8322bcb99a305ec8b058b60b9fdcd4978c442755e500c1bce92c33093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>admixture</topic><topic>Amazon</topic><topic>armadillos</topic><topic>Deoxyribonucleic acid</topic><topic>Divergence</topic><topic>DNA</topic><topic>Fungi</topic><topic>Genomes</topic><topic>Genotypes</topic><topic>Genotyping</topic><topic>Laboratory animals</topic><topic>Paracoccidioides</topic><topic>paracoccidioidomycosis</topic><topic>Pathogens</topic><topic>Phylogenetics</topic><topic>Population genetics</topic><topic>Population structure</topic><topic>Principal components analysis</topic><topic>South American blastomycosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bagagli, Eduardo</creatorcontrib><creatorcontrib>Matute, Daniel Ricardo</creatorcontrib><creatorcontrib>Garces, Hans Garcia</creatorcontrib><creatorcontrib>Tenório, Bernardo Guerra</creatorcontrib><creatorcontrib>Garces, Adalberto Garcia</creatorcontrib><creatorcontrib>Alves, Lucas Gomes de Brito</creatorcontrib><creatorcontrib>Yamauchi, Danielle Hamae</creatorcontrib><creatorcontrib>Hrycyk, Marluce Francisca</creatorcontrib><creatorcontrib>Barker, Bridget Marie</creatorcontrib><creatorcontrib>Teixeira, Marcus de Melo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of fungi (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bagagli, Eduardo</au><au>Matute, Daniel Ricardo</au><au>Garces, Hans Garcia</au><au>Tenório, Bernardo Guerra</au><au>Garces, Adalberto Garcia</au><au>Alves, Lucas Gomes de Brito</au><au>Yamauchi, Danielle Hamae</au><au>Hrycyk, Marluce Francisca</au><au>Barker, Bridget Marie</au><au>Teixeira, Marcus de Melo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paracoccidioides brasiliensis Isolated from Nine-Banded Armadillos ( Dasypus novemcinctus ) Reveal Population Structure and Admixture in the Amazon Basin</atitle><jtitle>Journal of fungi (Basel)</jtitle><addtitle>J Fungi (Basel)</addtitle><date>2021-01-15</date><risdate>2021</risdate><volume>7</volume><issue>1</issue><spage>54</spage><pages>54-</pages><issn>2309-608X</issn><eissn>2309-608X</eissn><abstract>Paracoccidioidomycosis is an endemic fungal disease to Latin America caused by at least five species-level genotypes of
, named
,
(S1a and S1b populations),
,
, and
. In this manuscript, we report on
sp. sampling efforts in armadillos from two different areas in Brazil. We sequenced the genomes of seven
isolates and used phylogenomics and populations genetics for genotyping. We found that
and
are both present in the Amazon region. Additionally, we identified two
isolates that seem to be the result of admixture between divergent populations within
sensu stricto. Both of these isolates were recovered from armadillos in a
endemic area in Midwestern Brazil. Additionally, two isolates from human patients also show evidence of resulting from admixture. Our results suggest that the populations of
sensu stricto exchange genes in nature. More generally, they suggest that population structure and admixture within species is an important source of variation for pathogenic fungi.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33467393</pmid><doi>10.3390/jof7010054</doi><orcidid>https://orcid.org/0000-0002-7501-3362</orcidid><orcidid>https://orcid.org/0000-0002-8003-4109</orcidid><orcidid>https://orcid.org/0000-0002-6100-3534</orcidid><orcidid>https://orcid.org/0000-0002-3439-4517</orcidid><orcidid>https://orcid.org/0000-0003-1763-3464</orcidid><orcidid>https://orcid.org/0000-0001-8932-3954</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | admixture Amazon armadillos Deoxyribonucleic acid Divergence DNA Fungi Genomes Genotypes Genotyping Laboratory animals Paracoccidioides paracoccidioidomycosis Pathogens Phylogenetics Population genetics Population structure Principal components analysis South American blastomycosis |
| title | Paracoccidioides brasiliensis Isolated from Nine-Banded Armadillos ( Dasypus novemcinctus ) Reveal Population Structure and Admixture in the Amazon Basin |
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