Synthesis, spectral characterization and anticancer activity of novel pyrimidine derivatives

The main objective of this work was to synthesize, characterize and evaluate the anticancer activity of novel pyrimidine derivatives. The present investigation was undertaken to synthesize pyrimidine derivatives containing pyrrole nucleus The compounds 4-[aminomethyl]-N-(4-methyl-3-{[4-(1H-pyrrol-2-yl) pyrimidin-2yl]amino}phenyl) benzamide (13f) and 4-[ ( propylamino ) methyl] - N- ( 4- methyl - 3 - { [ 4- ( 1H- pyrrol- 2yl) pyrimidin- 2 -yl] amino} phenyl) benzamide (13h) was prepared by conventional method. All the synthesized compounds were characterized by spectral (IR, NMR and MS) methods. The synthesized compounds were evaluated for their in vitro anticancer activity against non-small cell lung cancer A549 cell line by using 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. All the synthesized compounds showed characteristic peaks in FTIR, d NMR and Mass spectral analysis. In vitro anticancer activity revealed that 13f and 13h showed more potent anticancer activity as compared to the standard drug sunitinib. We designed and synthesized novel pyrimidine derivatives by conventional method. The anticancer activity determined by MTT assay showed compound 13f and 13h can be developed as a potential anticancer agent.