Study of the physicochemical and biological properties of the new promising Ti–20Nb–13Ta–5Zr alloy for biomedical applications

A technology for producing a new homogeneous Ti–20Nb–13Ta–5Zr alloy has been developed. It is shown that the alloy is single-phase with a β-Ti type crystal lattice. The alloy has the required mechanical properties (tensile strength of about 745 MPa). On the surface of plates and wire made of alloy, a relief of micro- and nanoscale is observed. In terms of the ability to generate reactive oxygen species and long-lived reactive protein species, the Ti–20Nb–13Ta–5Zr alloy is more preferable than nitinol. It was established that cell cultures growing on plates or wire made of Ti–20Nb–13Ta–5Zr alloy had a significant mitotic index (2%). The number of viable cells was at least 95–96% of the overall cell count. According to the results of implantation of the alloy in the form of plates or wire ring to animals, it can be concluded that the alloy is biocompatible. The morphology of the surface of the samples did not change after biological experiments. It can be assumed that the alloy Ti–20Nb–13Ta–5Zr is a material potentially suitable for medical applications. [Display omitted] •Developed manufacturing technology of a new homogeneous alloy Ti–25Nb–10Ta–5Zr.•Wire and plates from the alloy have excellent physicochemical and mechanical properties.•The alloy reacts with biological fluids much worse than nitinol.•Using cell and animal models, it was shown that alloy is biocompatible.