Piperlongumine inhibits the growth of non-small cell lung cancer cells via the miR-34b-3p/TGFBR1 pathway

Background Non-small cell lung cancer is a common type of lung cancer. Piperlongumine (PL), which is extracted from the roots of piperaceae plant, long pepper, and peppercorn, is an alkaloid amide that inhibits tumor growth and metastasis. However, whether it affects lung cancer cells remains unclea...

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Veröffentlicht in:	BMC complementary and alternative medicine 2021-01, Vol.21 (1), p.15-10, Article 15
Hauptverfasser:	Lu, Xinhua, Xu, Chenyang, Xu, Zhexuan, Lu, Chunya, Yang, Rui, Zhang, Furui, Zhang, Guojun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative medicine Animals Antibodies Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Automation Cancer Cancer cells Carcinoma, Non-Small-Cell Lung - drug therapy Care and treatment Cell cycle Cell growth Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Chromosome 3 Dioxolanes - pharmacology Epithelial cells Experiments Female Gene Expression Regulation, Neoplastic Growth Growth factors Humans Integrative & Complementary Medicine Laboratory animals Life Sciences & Biomedicine Lung cancer Lung cancer, Non-small cell Lung cancer, Small cell Medical prognosis Metastases Metastasis Mice Mice, Inbred BALB C MicroRNA MicroRNAs MicroRNAs - metabolism miR-34b-3p miRNA Non-small cell lung carcinoma Non-small-cell lung cancer Piper longum Piperlongumine Plasmids Proteins Reagents Receptor, Transforming Growth Factor-beta Type I - metabolism Ribonucleic acid RNA Science & Technology Signal transduction Signal Transduction - drug effects Small cell lung carcinoma TGFBR1 Transforming growth factor-b Tumors Up-Regulation Xenograft Model Antitumor Assays
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