Maternal organic selenium supplementation during gestation improves the antioxidant capacity and reduces the inflammation level in the intestine of offspring through the NF-κB and ERK/Beclin-1 pathways
Selenium (Se) is postulated to protect against inflammation in the gut by attenuating oxidative stress. This study was conducted to investigate the effects of maternal 2-hydroxy-4-methylselenobutanoic acid (HMSeBA), an organic Se source, on the intestinal antioxidant capacity and inflammation level...
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| creator | Mou, Daolin Ding, Dajiang Yang, Min Jiang, Xuemei Zhao, Lianpeng Che, Lianqiang Fang, Zhengfeng Xu, Shengyu Lin, Yan Zhuo, Yong Li, Jian Huang, Chao Zou, Yuanfeng Li, Lixia Wu, De Feng, Bin |
| description | Selenium (Se) is postulated to protect against inflammation in the gut by attenuating oxidative stress. This study was conducted to investigate the effects of maternal 2-hydroxy-4-methylselenobutanoic acid (HMSeBA), an organic Se source, on the intestinal antioxidant capacity and inflammation level of the offspring and its possible mechanism. Forty-three sows were randomly assigned to receive one of the following three diets during gestation: control diet, sodium selenite (Na
2
SeO
3
) supplemented diet or HMSeBA supplemented diet, respectively. Samples were collected from the offspring at birth and weaning. The results showed that maternal HMSeBA supplementation significantly upregulated ileal GPX2 and SePP1 gene expression compared with the control and Na
2
SeO
3
groups, while suppressed the expression of ileal IL-1β, IL-6 and NF-κB genes in newborn piglets compared with the control group. Moreover, maternal HMSeBA supplementation significantly increased the protein of ileal GPX2 and p-mTOR compared with the control and Na
2
SeO
3
groups, but decreased the ileal p-NF-κB, Beclin-1 and p-ERK proteins in newborn piglets compared with the control group. The weaned piglets of the HMSeBA group had lower serum IL-1β and IL-6 than the piglets of the control group at 2 h of LPS challenge. In addition, after the LPS challenge, the HMSeBA group had a lower relative abundance of ileal p-NF-κB and Beclin-1 proteins than the control and Na
2
SeO
3
groups. In conclusion, maternal HMSeBA supplementation during gestation can improve the offspring's intestinal antioxidant capacity and reduce the inflammation level by suppressing NF-κB and ERK/Beclin-1 signaling.
Maternal HMSeBA supplementation during gestation improves offspring's intestinal antioxidant capacity and reduces the intestinal inflammation level by suppressing NF-κB and ERK/Beclin-1 signaling. |
| doi_str_mv | 10.1039/d0fo02274h |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2478619170</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2469094413</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-f2f6e51413f4200c032e360c98bef0fbaf842e74328fc4dcd9dabb980aaba5a93</originalsourceid><addsrcrecordid>eNpdksFu1DAQhiNERavSC3eQJS6oUujE9ibxkZYuRW2phEDiFjnOeOPKcYKdlO6r8QgceCa8u2mRalka65_P_9geJ8mrDN5nwMRJA7oHSgvePksOKHCa5gv48fxhzUW-nxyFcAtxMCFKUb5I9hljAALYQfLnWo7onbSk9yvpjCIBLTozdSRMw2CxQzfK0fSONJM3bkVWGGbBdIPv7zCQsUUiXdTuTRMjUXKQyozrKDbEYzOpGTJOW9l1u-0W79BGac6M0dc4JL2OU4dhW2xsfT-t2i3yZZn-_X269Tz_enlyisoal2ZkkGP7S67Dy2RPSxvwaI6Hyffl-bezi_Tq5tPnsw9XqWJFOaaa6hwXGc-Y5hRAAaPIclCirFGDrqUuOcWCM1pqxRvViEbWtShByloupGCHybudb7z9zymeuupMUGitdNhPoaI8FyB4LBDRt0_Q237avPaGKso8E1kBkTreUcr3IXjUVbx8J_26yqDaNLn6CMubbZMvIvxmtpzqDptH9KGlEXi9A3xQj9n_v4T9AzGosVE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2478619170</pqid></control><display><type>article</type><title>Maternal organic selenium supplementation during gestation improves the antioxidant capacity and reduces the inflammation level in the intestine of offspring through the NF-κB and ERK/Beclin-1 pathways</title><source>Royal Society Of Chemistry Journals 2008-</source><creator>Mou, Daolin ; Ding, Dajiang ; Yang, Min ; Jiang, Xuemei ; Zhao, Lianpeng ; Che, Lianqiang ; Fang, Zhengfeng ; Xu, Shengyu ; Lin, Yan ; Zhuo, Yong ; Li, Jian ; Huang, Chao ; Zou, Yuanfeng ; Li, Lixia ; Wu, De ; Feng, Bin</creator><creatorcontrib>Mou, Daolin ; Ding, Dajiang ; Yang, Min ; Jiang, Xuemei ; Zhao, Lianpeng ; Che, Lianqiang ; Fang, Zhengfeng ; Xu, Shengyu ; Lin, Yan ; Zhuo, Yong ; Li, Jian ; Huang, Chao ; Zou, Yuanfeng ; Li, Lixia ; Wu, De ; Feng, Bin</creatorcontrib><description>Selenium (Se) is postulated to protect against inflammation in the gut by attenuating oxidative stress. This study was conducted to investigate the effects of maternal 2-hydroxy-4-methylselenobutanoic acid (HMSeBA), an organic Se source, on the intestinal antioxidant capacity and inflammation level of the offspring and its possible mechanism. Forty-three sows were randomly assigned to receive one of the following three diets during gestation: control diet, sodium selenite (Na
2
SeO
3
) supplemented diet or HMSeBA supplemented diet, respectively. Samples were collected from the offspring at birth and weaning. The results showed that maternal HMSeBA supplementation significantly upregulated ileal GPX2 and SePP1 gene expression compared with the control and Na
2
SeO
3
groups, while suppressed the expression of ileal IL-1β, IL-6 and NF-κB genes in newborn piglets compared with the control group. Moreover, maternal HMSeBA supplementation significantly increased the protein of ileal GPX2 and p-mTOR compared with the control and Na
2
SeO
3
groups, but decreased the ileal p-NF-κB, Beclin-1 and p-ERK proteins in newborn piglets compared with the control group. The weaned piglets of the HMSeBA group had lower serum IL-1β and IL-6 than the piglets of the control group at 2 h of LPS challenge. In addition, after the LPS challenge, the HMSeBA group had a lower relative abundance of ileal p-NF-κB and Beclin-1 proteins than the control and Na
2
SeO
3
groups. In conclusion, maternal HMSeBA supplementation during gestation can improve the offspring's intestinal antioxidant capacity and reduce the inflammation level by suppressing NF-κB and ERK/Beclin-1 signaling.
Maternal HMSeBA supplementation during gestation improves offspring's intestinal antioxidant capacity and reduces the intestinal inflammation level by suppressing NF-κB and ERK/Beclin-1 signaling.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d0fo02274h</identifier><identifier>PMID: 33300903</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Antioxidants ; Diet ; Dietary supplements ; Extracellular signal-regulated kinase ; Gene expression ; Gestation ; IL-1β ; Inflammation ; Interleukin 6 ; Intestine ; Lipopolysaccharides ; NF-κB protein ; Offspring ; Oxidative stress ; Proteins ; Relative abundance ; Selenium ; Sodium selenite ; TOR protein ; Weaning</subject><ispartof>Food & function, 2021-01, Vol.12 (1), p.315-327</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-f2f6e51413f4200c032e360c98bef0fbaf842e74328fc4dcd9dabb980aaba5a93</citedby><cites>FETCH-LOGICAL-c378t-f2f6e51413f4200c032e360c98bef0fbaf842e74328fc4dcd9dabb980aaba5a93</cites><orcidid>0000-0002-0940-7275 ; 0000-0002-9581-5418</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33300903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mou, Daolin</creatorcontrib><creatorcontrib>Ding, Dajiang</creatorcontrib><creatorcontrib>Yang, Min</creatorcontrib><creatorcontrib>Jiang, Xuemei</creatorcontrib><creatorcontrib>Zhao, Lianpeng</creatorcontrib><creatorcontrib>Che, Lianqiang</creatorcontrib><creatorcontrib>Fang, Zhengfeng</creatorcontrib><creatorcontrib>Xu, Shengyu</creatorcontrib><creatorcontrib>Lin, Yan</creatorcontrib><creatorcontrib>Zhuo, Yong</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Huang, Chao</creatorcontrib><creatorcontrib>Zou, Yuanfeng</creatorcontrib><creatorcontrib>Li, Lixia</creatorcontrib><creatorcontrib>Wu, De</creatorcontrib><creatorcontrib>Feng, Bin</creatorcontrib><title>Maternal organic selenium supplementation during gestation improves the antioxidant capacity and reduces the inflammation level in the intestine of offspring through the NF-κB and ERK/Beclin-1 pathways</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Selenium (Se) is postulated to protect against inflammation in the gut by attenuating oxidative stress. This study was conducted to investigate the effects of maternal 2-hydroxy-4-methylselenobutanoic acid (HMSeBA), an organic Se source, on the intestinal antioxidant capacity and inflammation level of the offspring and its possible mechanism. Forty-three sows were randomly assigned to receive one of the following three diets during gestation: control diet, sodium selenite (Na
2
SeO
3
) supplemented diet or HMSeBA supplemented diet, respectively. Samples were collected from the offspring at birth and weaning. The results showed that maternal HMSeBA supplementation significantly upregulated ileal GPX2 and SePP1 gene expression compared with the control and Na
2
SeO
3
groups, while suppressed the expression of ileal IL-1β, IL-6 and NF-κB genes in newborn piglets compared with the control group. Moreover, maternal HMSeBA supplementation significantly increased the protein of ileal GPX2 and p-mTOR compared with the control and Na
2
SeO
3
groups, but decreased the ileal p-NF-κB, Beclin-1 and p-ERK proteins in newborn piglets compared with the control group. The weaned piglets of the HMSeBA group had lower serum IL-1β and IL-6 than the piglets of the control group at 2 h of LPS challenge. In addition, after the LPS challenge, the HMSeBA group had a lower relative abundance of ileal p-NF-κB and Beclin-1 proteins than the control and Na
2
SeO
3
groups. In conclusion, maternal HMSeBA supplementation during gestation can improve the offspring's intestinal antioxidant capacity and reduce the inflammation level by suppressing NF-κB and ERK/Beclin-1 signaling.
Maternal HMSeBA supplementation during gestation improves offspring's intestinal antioxidant capacity and reduces the intestinal inflammation level by suppressing NF-κB and ERK/Beclin-1 signaling.</description><subject>Antioxidants</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Extracellular signal-regulated kinase</subject><subject>Gene expression</subject><subject>Gestation</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Intestine</subject><subject>Lipopolysaccharides</subject><subject>NF-κB protein</subject><subject>Offspring</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Relative abundance</subject><subject>Selenium</subject><subject>Sodium selenite</subject><subject>TOR protein</subject><subject>Weaning</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdksFu1DAQhiNERavSC3eQJS6oUujE9ibxkZYuRW2phEDiFjnOeOPKcYKdlO6r8QgceCa8u2mRalka65_P_9geJ8mrDN5nwMRJA7oHSgvePksOKHCa5gv48fxhzUW-nxyFcAtxMCFKUb5I9hljAALYQfLnWo7onbSk9yvpjCIBLTozdSRMw2CxQzfK0fSONJM3bkVWGGbBdIPv7zCQsUUiXdTuTRMjUXKQyozrKDbEYzOpGTJOW9l1u-0W79BGac6M0dc4JL2OU4dhW2xsfT-t2i3yZZn-_X269Tz_enlyisoal2ZkkGP7S67Dy2RPSxvwaI6Hyffl-bezi_Tq5tPnsw9XqWJFOaaa6hwXGc-Y5hRAAaPIclCirFGDrqUuOcWCM1pqxRvViEbWtShByloupGCHybudb7z9zymeuupMUGitdNhPoaI8FyB4LBDRt0_Q237avPaGKso8E1kBkTreUcr3IXjUVbx8J_26yqDaNLn6CMubbZMvIvxmtpzqDptH9KGlEXi9A3xQj9n_v4T9AzGosVE</recordid><startdate>20210107</startdate><enddate>20210107</enddate><creator>Mou, Daolin</creator><creator>Ding, Dajiang</creator><creator>Yang, Min</creator><creator>Jiang, Xuemei</creator><creator>Zhao, Lianpeng</creator><creator>Che, Lianqiang</creator><creator>Fang, Zhengfeng</creator><creator>Xu, Shengyu</creator><creator>Lin, Yan</creator><creator>Zhuo, Yong</creator><creator>Li, Jian</creator><creator>Huang, Chao</creator><creator>Zou, Yuanfeng</creator><creator>Li, Lixia</creator><creator>Wu, De</creator><creator>Feng, Bin</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0940-7275</orcidid><orcidid>https://orcid.org/0000-0002-9581-5418</orcidid></search><sort><creationdate>20210107</creationdate><title>Maternal organic selenium supplementation during gestation improves the antioxidant capacity and reduces the inflammation level in the intestine of offspring through the NF-κB and ERK/Beclin-1 pathways</title><author>Mou, Daolin ; Ding, Dajiang ; Yang, Min ; Jiang, Xuemei ; Zhao, Lianpeng ; Che, Lianqiang ; Fang, Zhengfeng ; Xu, Shengyu ; Lin, Yan ; Zhuo, Yong ; Li, Jian ; Huang, Chao ; Zou, Yuanfeng ; Li, Lixia ; Wu, De ; Feng, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-f2f6e51413f4200c032e360c98bef0fbaf842e74328fc4dcd9dabb980aaba5a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidants</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Extracellular signal-regulated kinase</topic><topic>Gene expression</topic><topic>Gestation</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Intestine</topic><topic>Lipopolysaccharides</topic><topic>NF-κB protein</topic><topic>Offspring</topic><topic>Oxidative stress</topic><topic>Proteins</topic><topic>Relative abundance</topic><topic>Selenium</topic><topic>Sodium selenite</topic><topic>TOR protein</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mou, Daolin</creatorcontrib><creatorcontrib>Ding, Dajiang</creatorcontrib><creatorcontrib>Yang, Min</creatorcontrib><creatorcontrib>Jiang, Xuemei</creatorcontrib><creatorcontrib>Zhao, Lianpeng</creatorcontrib><creatorcontrib>Che, Lianqiang</creatorcontrib><creatorcontrib>Fang, Zhengfeng</creatorcontrib><creatorcontrib>Xu, Shengyu</creatorcontrib><creatorcontrib>Lin, Yan</creatorcontrib><creatorcontrib>Zhuo, Yong</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Huang, Chao</creatorcontrib><creatorcontrib>Zou, Yuanfeng</creatorcontrib><creatorcontrib>Li, Lixia</creatorcontrib><creatorcontrib>Wu, De</creatorcontrib><creatorcontrib>Feng, Bin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mou, Daolin</au><au>Ding, Dajiang</au><au>Yang, Min</au><au>Jiang, Xuemei</au><au>Zhao, Lianpeng</au><au>Che, Lianqiang</au><au>Fang, Zhengfeng</au><au>Xu, Shengyu</au><au>Lin, Yan</au><au>Zhuo, Yong</au><au>Li, Jian</au><au>Huang, Chao</au><au>Zou, Yuanfeng</au><au>Li, Lixia</au><au>Wu, De</au><au>Feng, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal organic selenium supplementation during gestation improves the antioxidant capacity and reduces the inflammation level in the intestine of offspring through the NF-κB and ERK/Beclin-1 pathways</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2021-01-07</date><risdate>2021</risdate><volume>12</volume><issue>1</issue><spage>315</spage><epage>327</epage><pages>315-327</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Selenium (Se) is postulated to protect against inflammation in the gut by attenuating oxidative stress. This study was conducted to investigate the effects of maternal 2-hydroxy-4-methylselenobutanoic acid (HMSeBA), an organic Se source, on the intestinal antioxidant capacity and inflammation level of the offspring and its possible mechanism. Forty-three sows were randomly assigned to receive one of the following three diets during gestation: control diet, sodium selenite (Na
2
SeO
3
) supplemented diet or HMSeBA supplemented diet, respectively. Samples were collected from the offspring at birth and weaning. The results showed that maternal HMSeBA supplementation significantly upregulated ileal GPX2 and SePP1 gene expression compared with the control and Na
2
SeO
3
groups, while suppressed the expression of ileal IL-1β, IL-6 and NF-κB genes in newborn piglets compared with the control group. Moreover, maternal HMSeBA supplementation significantly increased the protein of ileal GPX2 and p-mTOR compared with the control and Na
2
SeO
3
groups, but decreased the ileal p-NF-κB, Beclin-1 and p-ERK proteins in newborn piglets compared with the control group. The weaned piglets of the HMSeBA group had lower serum IL-1β and IL-6 than the piglets of the control group at 2 h of LPS challenge. In addition, after the LPS challenge, the HMSeBA group had a lower relative abundance of ileal p-NF-κB and Beclin-1 proteins than the control and Na
2
SeO
3
groups. In conclusion, maternal HMSeBA supplementation during gestation can improve the offspring's intestinal antioxidant capacity and reduce the inflammation level by suppressing NF-κB and ERK/Beclin-1 signaling.
Maternal HMSeBA supplementation during gestation improves offspring's intestinal antioxidant capacity and reduces the intestinal inflammation level by suppressing NF-κB and ERK/Beclin-1 signaling.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>33300903</pmid><doi>10.1039/d0fo02274h</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-0940-7275</orcidid><orcidid>https://orcid.org/0000-0002-9581-5418</orcidid></addata></record> |
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| ispartof | Food & function, 2021-01, Vol.12 (1), p.315-327 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Antioxidants Diet Dietary supplements Extracellular signal-regulated kinase Gene expression Gestation IL-1β Inflammation Interleukin 6 Intestine Lipopolysaccharides NF-κB protein Offspring Oxidative stress Proteins Relative abundance Selenium Sodium selenite TOR protein Weaning |
| title | Maternal organic selenium supplementation during gestation improves the antioxidant capacity and reduces the inflammation level in the intestine of offspring through the NF-κB and ERK/Beclin-1 pathways |
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