Peripheral blood T lymphocytosis in thymoma: an insight into immunobiology
Purpose Peripheral blood T lymphocytosis (PBTL) is a rare, yet poorly understood manifestations of thymoma, which is postulated to be linked with autoimmune/paraneoplastic manifestations such as myasthenia gravis (MG), pure red cell aplasia (PRCA), etc.; more commonly encountered in this neoplasm. M...
Gespeichert in:
| Veröffentlicht in: | Journal of cancer research and clinical oncology 2021, Vol.147 (1), p.295-301 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 301 |
|---|---|
| container_issue | 1 |
| container_start_page | 295 |
| container_title | Journal of cancer research and clinical oncology |
| container_volume | 147 |
| creator | Mishra, Shruti Padhi, Somanath Adhya, Amit Kumar DasMajumdar, Saroj Kumar Pattnaik, Ashutosh Chhabra, Gaurav |
| description | Purpose
Peripheral blood T lymphocytosis (PBTL) is a rare, yet poorly understood manifestations of thymoma, which is postulated to be linked with autoimmune/paraneoplastic manifestations such as myasthenia gravis (MG), pure red cell aplasia (PRCA), etc.; more commonly encountered in this neoplasm.
Method
We aim to describe the flowcytometric immunophenotypic data of PBTL in a 43-year-old male; 6 months after successful completion of chemoradiotherapy (CT/RT) for a large, invasive, and metastatic type B1 thymoma; and present a comprehensive review of all such cases reported over last 42 years (
N
= 21) (1977–2019).
Result
A larger size of the tumors (≥ 10 cm), presence of local invasion and/or distant metastasis, and type B (cortical or lymphocyte rich) histology were more likely to be associated with PBTL. Tumors associated with MG/PRCA (
N
= 9/21) tend to have lower PBTL compared to those without such manifestations; and PBTL subsided following thymectomy with or without CT/RT. Immunophenotypic analysis of PB revealed a CD8 + > CD4 + mature (naïve) polyclonal T cells resembling late cortical thymocytes.
Conclusion
Thymic intratumoral microenvironment might influence occurrence PBTL that may have a pathophysiologic link to development of autoimmune manifestations. Immunophenotypic characteristics of peripheral blood lymphoid cells should be the clue for accurate characterization and to avoid a misdiagnosis of a lymphoproliferative neoplasm. |
| doi_str_mv | 10.1007/s00432-020-03440-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2478164735</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2478164735</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-91055380fefbaf01e9ed3bbf54245caa1d416aea50fad51a60f2bed9857d9fc93</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EoqXwAyxQJNaG8Stp2KGKpyrBoqwtJ7GbVEkc7GSRv8clBXasRjNz517NQeiSwA0BSG49AGcUAwUMjHPA9AjNyX5EGBPHaA4kIVhQEs_Qmfc7CL1I6CmaMUZiTng6R6_v2lVdqZ2qo6y2tog2UT02XWnzsbe-8lHVRn05NrZRd5FqQ-urbdmH2tuoapqhtVlla7sdz9GJUbXXF4e6QB-PD5vVM16_Pb2s7tc4Z5z2OCUgBFuC0SZTBohOdcGyzAhOuciVIgUnsdJKgFGFICoGQzNdpEuRFKnJU7ZA15Nv5-znoH0vd3ZwbYiUlCfL8FnCRFDRSZU7673TRnauapQbJQG5xycnfDLgk9_4JA1HVwfrIWt08XvywysI2CTwYdVutfvL_sf2C_pge4A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2478164735</pqid></control><display><type>article</type><title>Peripheral blood T lymphocytosis in thymoma: an insight into immunobiology</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Mishra, Shruti ; Padhi, Somanath ; Adhya, Amit Kumar ; DasMajumdar, Saroj Kumar ; Pattnaik, Ashutosh ; Chhabra, Gaurav</creator><creatorcontrib>Mishra, Shruti ; Padhi, Somanath ; Adhya, Amit Kumar ; DasMajumdar, Saroj Kumar ; Pattnaik, Ashutosh ; Chhabra, Gaurav</creatorcontrib><description>Purpose
Peripheral blood T lymphocytosis (PBTL) is a rare, yet poorly understood manifestations of thymoma, which is postulated to be linked with autoimmune/paraneoplastic manifestations such as myasthenia gravis (MG), pure red cell aplasia (PRCA), etc.; more commonly encountered in this neoplasm.
Method
We aim to describe the flowcytometric immunophenotypic data of PBTL in a 43-year-old male; 6 months after successful completion of chemoradiotherapy (CT/RT) for a large, invasive, and metastatic type B1 thymoma; and present a comprehensive review of all such cases reported over last 42 years (
N
= 21) (1977–2019).
Result
A larger size of the tumors (≥ 10 cm), presence of local invasion and/or distant metastasis, and type B (cortical or lymphocyte rich) histology were more likely to be associated with PBTL. Tumors associated with MG/PRCA (
N
= 9/21) tend to have lower PBTL compared to those without such manifestations; and PBTL subsided following thymectomy with or without CT/RT. Immunophenotypic analysis of PB revealed a CD8 + > CD4 + mature (naïve) polyclonal T cells resembling late cortical thymocytes.
Conclusion
Thymic intratumoral microenvironment might influence occurrence PBTL that may have a pathophysiologic link to development of autoimmune manifestations. Immunophenotypic characteristics of peripheral blood lymphoid cells should be the clue for accurate characterization and to avoid a misdiagnosis of a lymphoproliferative neoplasm.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-020-03440-2</identifier><identifier>PMID: 33164149</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aplasia ; Cancer Research ; CD4 antigen ; CD8 antigen ; Chemoradiotherapy ; Chemoradiotherapy - methods ; Hematology ; Humans ; Internal Medicine ; Letter to the Editor ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Lymphocytosis ; Lymphocytosis - complications ; Lymphocytosis - immunology ; Lymphocytosis - pathology ; Lymphocytosis - therapy ; Lymphoid cells ; Male ; Medicine ; Medicine & Public Health ; Metastases ; Microenvironments ; Myasthenia ; Myasthenia gravis ; Neuromuscular junctions ; Oncology ; Peripheral blood ; Prognosis ; T-Lymphocytes - immunology ; T-Lymphocytes - pathology ; Thymectomy ; Thymocytes ; Thymoma ; Thymoma - complications ; Thymoma - immunology ; Thymoma - pathology ; Thymoma - therapy ; Thymus ; Thymus Neoplasms - complications ; Thymus Neoplasms - immunology ; Thymus Neoplasms - pathology ; Thymus Neoplasms - therapy ; Tumors</subject><ispartof>Journal of cancer research and clinical oncology, 2021, Vol.147 (1), p.295-301</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-91055380fefbaf01e9ed3bbf54245caa1d416aea50fad51a60f2bed9857d9fc93</citedby><cites>FETCH-LOGICAL-c342t-91055380fefbaf01e9ed3bbf54245caa1d416aea50fad51a60f2bed9857d9fc93</cites><orcidid>0000-0002-3452-7236</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-020-03440-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-020-03440-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33164149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mishra, Shruti</creatorcontrib><creatorcontrib>Padhi, Somanath</creatorcontrib><creatorcontrib>Adhya, Amit Kumar</creatorcontrib><creatorcontrib>DasMajumdar, Saroj Kumar</creatorcontrib><creatorcontrib>Pattnaik, Ashutosh</creatorcontrib><creatorcontrib>Chhabra, Gaurav</creatorcontrib><title>Peripheral blood T lymphocytosis in thymoma: an insight into immunobiology</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
Peripheral blood T lymphocytosis (PBTL) is a rare, yet poorly understood manifestations of thymoma, which is postulated to be linked with autoimmune/paraneoplastic manifestations such as myasthenia gravis (MG), pure red cell aplasia (PRCA), etc.; more commonly encountered in this neoplasm.
Method
We aim to describe the flowcytometric immunophenotypic data of PBTL in a 43-year-old male; 6 months after successful completion of chemoradiotherapy (CT/RT) for a large, invasive, and metastatic type B1 thymoma; and present a comprehensive review of all such cases reported over last 42 years (
N
= 21) (1977–2019).
Result
A larger size of the tumors (≥ 10 cm), presence of local invasion and/or distant metastasis, and type B (cortical or lymphocyte rich) histology were more likely to be associated with PBTL. Tumors associated with MG/PRCA (
N
= 9/21) tend to have lower PBTL compared to those without such manifestations; and PBTL subsided following thymectomy with or without CT/RT. Immunophenotypic analysis of PB revealed a CD8 + > CD4 + mature (naïve) polyclonal T cells resembling late cortical thymocytes.
Conclusion
Thymic intratumoral microenvironment might influence occurrence PBTL that may have a pathophysiologic link to development of autoimmune manifestations. Immunophenotypic characteristics of peripheral blood lymphoid cells should be the clue for accurate characterization and to avoid a misdiagnosis of a lymphoproliferative neoplasm.</description><subject>Adult</subject><subject>Aplasia</subject><subject>Cancer Research</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>Chemoradiotherapy</subject><subject>Chemoradiotherapy - methods</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Letter to the Editor</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Lymphocytosis</subject><subject>Lymphocytosis - complications</subject><subject>Lymphocytosis - immunology</subject><subject>Lymphocytosis - pathology</subject><subject>Lymphocytosis - therapy</subject><subject>Lymphoid cells</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Microenvironments</subject><subject>Myasthenia</subject><subject>Myasthenia gravis</subject><subject>Neuromuscular junctions</subject><subject>Oncology</subject><subject>Peripheral blood</subject><subject>Prognosis</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - pathology</subject><subject>Thymectomy</subject><subject>Thymocytes</subject><subject>Thymoma</subject><subject>Thymoma - complications</subject><subject>Thymoma - immunology</subject><subject>Thymoma - pathology</subject><subject>Thymoma - therapy</subject><subject>Thymus</subject><subject>Thymus Neoplasms - complications</subject><subject>Thymus Neoplasms - immunology</subject><subject>Thymus Neoplasms - pathology</subject><subject>Thymus Neoplasms - therapy</subject><subject>Tumors</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyxQJNaG8Stp2KGKpyrBoqwtJ7GbVEkc7GSRv8clBXasRjNz517NQeiSwA0BSG49AGcUAwUMjHPA9AjNyX5EGBPHaA4kIVhQEs_Qmfc7CL1I6CmaMUZiTng6R6_v2lVdqZ2qo6y2tog2UT02XWnzsbe-8lHVRn05NrZRd5FqQ-urbdmH2tuoapqhtVlla7sdz9GJUbXXF4e6QB-PD5vVM16_Pb2s7tc4Z5z2OCUgBFuC0SZTBohOdcGyzAhOuciVIgUnsdJKgFGFICoGQzNdpEuRFKnJU7ZA15Nv5-znoH0vd3ZwbYiUlCfL8FnCRFDRSZU7673TRnauapQbJQG5xycnfDLgk9_4JA1HVwfrIWt08XvywysI2CTwYdVutfvL_sf2C_pge4A</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Mishra, Shruti</creator><creator>Padhi, Somanath</creator><creator>Adhya, Amit Kumar</creator><creator>DasMajumdar, Saroj Kumar</creator><creator>Pattnaik, Ashutosh</creator><creator>Chhabra, Gaurav</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-3452-7236</orcidid></search><sort><creationdate>2021</creationdate><title>Peripheral blood T lymphocytosis in thymoma: an insight into immunobiology</title><author>Mishra, Shruti ; Padhi, Somanath ; Adhya, Amit Kumar ; DasMajumdar, Saroj Kumar ; Pattnaik, Ashutosh ; Chhabra, Gaurav</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-91055380fefbaf01e9ed3bbf54245caa1d416aea50fad51a60f2bed9857d9fc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aplasia</topic><topic>Cancer Research</topic><topic>CD4 antigen</topic><topic>CD8 antigen</topic><topic>Chemoradiotherapy</topic><topic>Chemoradiotherapy - methods</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Letter to the Editor</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Lymphocytosis</topic><topic>Lymphocytosis - complications</topic><topic>Lymphocytosis - immunology</topic><topic>Lymphocytosis - pathology</topic><topic>Lymphocytosis - therapy</topic><topic>Lymphoid cells</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Microenvironments</topic><topic>Myasthenia</topic><topic>Myasthenia gravis</topic><topic>Neuromuscular junctions</topic><topic>Oncology</topic><topic>Peripheral blood</topic><topic>Prognosis</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - pathology</topic><topic>Thymectomy</topic><topic>Thymocytes</topic><topic>Thymoma</topic><topic>Thymoma - complications</topic><topic>Thymoma - immunology</topic><topic>Thymoma - pathology</topic><topic>Thymoma - therapy</topic><topic>Thymus</topic><topic>Thymus Neoplasms - complications</topic><topic>Thymus Neoplasms - immunology</topic><topic>Thymus Neoplasms - pathology</topic><topic>Thymus Neoplasms - therapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mishra, Shruti</creatorcontrib><creatorcontrib>Padhi, Somanath</creatorcontrib><creatorcontrib>Adhya, Amit Kumar</creatorcontrib><creatorcontrib>DasMajumdar, Saroj Kumar</creatorcontrib><creatorcontrib>Pattnaik, Ashutosh</creatorcontrib><creatorcontrib>Chhabra, Gaurav</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mishra, Shruti</au><au>Padhi, Somanath</au><au>Adhya, Amit Kumar</au><au>DasMajumdar, Saroj Kumar</au><au>Pattnaik, Ashutosh</au><au>Chhabra, Gaurav</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral blood T lymphocytosis in thymoma: an insight into immunobiology</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2021</date><risdate>2021</risdate><volume>147</volume><issue>1</issue><spage>295</spage><epage>301</epage><pages>295-301</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
Peripheral blood T lymphocytosis (PBTL) is a rare, yet poorly understood manifestations of thymoma, which is postulated to be linked with autoimmune/paraneoplastic manifestations such as myasthenia gravis (MG), pure red cell aplasia (PRCA), etc.; more commonly encountered in this neoplasm.
Method
We aim to describe the flowcytometric immunophenotypic data of PBTL in a 43-year-old male; 6 months after successful completion of chemoradiotherapy (CT/RT) for a large, invasive, and metastatic type B1 thymoma; and present a comprehensive review of all such cases reported over last 42 years (
N
= 21) (1977–2019).
Result
A larger size of the tumors (≥ 10 cm), presence of local invasion and/or distant metastasis, and type B (cortical or lymphocyte rich) histology were more likely to be associated with PBTL. Tumors associated with MG/PRCA (
N
= 9/21) tend to have lower PBTL compared to those without such manifestations; and PBTL subsided following thymectomy with or without CT/RT. Immunophenotypic analysis of PB revealed a CD8 + > CD4 + mature (naïve) polyclonal T cells resembling late cortical thymocytes.
Conclusion
Thymic intratumoral microenvironment might influence occurrence PBTL that may have a pathophysiologic link to development of autoimmune manifestations. Immunophenotypic characteristics of peripheral blood lymphoid cells should be the clue for accurate characterization and to avoid a misdiagnosis of a lymphoproliferative neoplasm.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33164149</pmid><doi>10.1007/s00432-020-03440-2</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3452-7236</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2021, Vol.147 (1), p.295-301 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_proquest_journals_2478164735 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aplasia Cancer Research CD4 antigen CD8 antigen Chemoradiotherapy Chemoradiotherapy - methods Hematology Humans Internal Medicine Letter to the Editor Lymphocytes Lymphocytes B Lymphocytes T Lymphocytosis Lymphocytosis - complications Lymphocytosis - immunology Lymphocytosis - pathology Lymphocytosis - therapy Lymphoid cells Male Medicine Medicine & Public Health Metastases Microenvironments Myasthenia Myasthenia gravis Neuromuscular junctions Oncology Peripheral blood Prognosis T-Lymphocytes - immunology T-Lymphocytes - pathology Thymectomy Thymocytes Thymoma Thymoma - complications Thymoma - immunology Thymoma - pathology Thymoma - therapy Thymus Thymus Neoplasms - complications Thymus Neoplasms - immunology Thymus Neoplasms - pathology Thymus Neoplasms - therapy Tumors |
| title | Peripheral blood T lymphocytosis in thymoma: an insight into immunobiology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T11%3A04%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Peripheral%20blood%20T%20lymphocytosis%20in%20thymoma:%20an%20insight%20into%20immunobiology&rft.jtitle=Journal%20of%20cancer%20research%20and%20clinical%20oncology&rft.au=Mishra,%20Shruti&rft.date=2021&rft.volume=147&rft.issue=1&rft.spage=295&rft.epage=301&rft.pages=295-301&rft.issn=0171-5216&rft.eissn=1432-1335&rft_id=info:doi/10.1007/s00432-020-03440-2&rft_dat=%3Cproquest_cross%3E2478164735%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2478164735&rft_id=info:pmid/33164149&rfr_iscdi=true |