Mathematical modeling and analysis of tumor-volume variation during radiotherapy

•We develop a tumor growth dynamical model on oxygenated tumor cells and hypoxic tumor cells with pulsed radiotherapy.•We investigate how the reoxygenation of hypoxic cells and the radiosensitivity influence the effect of tumor radiotherapy.•We simulate the volumetric imaging data from 12 available...

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Veröffentlicht in:	Applied Mathematical Modelling 2021-01, Vol.89, p.1074-1089
Hauptverfasser:	Pang, Liuyong, Liu, Sanhong, Liu, Fang, Zhang, Xinan, Tian, Tianhai
Format:	Artikel
Sprache:	eng
Schlagworte:	Computed tomography Data fitting Dynamic models Hypoxia Mathematical modeling Precise treatment strategies Radiation therapy Radiotherapy Reoxygenation of hypoxic tumor cells Tumors
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