Indicated and non-indicated antibiotic administration during pregnancy and its effect on pregnancy outcomes: Role of inflammation
•Sterile inflammation is an important etiology of preterm labor.•Some antibiotics could induce pro-inflammatory cytokines in the absence of bacterial infection.•Consumption of some antibiotics in a non-infectious state may cause preterm labor. The objective of this study was to compare the release o...
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| Veröffentlicht in: | International immunopharmacology 2020-12, Vol.89 (Pt B), p.107081, Article 107081 |
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| creator | Ghazanfari, Tooba Norooznezhad, Amir Hossein Javidan, Shima Norouz, Leila Farzanehdoust, Azadeh Mansouri, Kamran Ahmadi, Mohammad Hossein Mostafaei, Shayan Javadian, Pouya Sheikh, Mahdi Hantoushzadeh, Sedigheh |
| description | •Sterile inflammation is an important etiology of preterm labor.•Some antibiotics could induce pro-inflammatory cytokines in the absence of bacterial infection.•Consumption of some antibiotics in a non-infectious state may cause preterm labor.
The objective of this study was to compare the release of endotoxin and pro-inflammatory cytokines as well as pregnancy outcomes after antibiotic exposure in healthy and bacterial infected pregnant rats. Thirty female Wistar pregnant rats were divided into five groups. Group A considered as control and received intraperitoneal saline 0.9% on 17th day of gestation or DG) and groups B and C treated with 20 mg/kg/day intravenous ceftriaxone and ceftazidime, respectively (DG: 18–20). Groups D and E received intraperitoneal E. coli and LPS on 17th DG respectively. Also, groups F and G received the same treatment as group D but they treated with the exact antibiotics mentioned for groups B and C (same dose and duration). Pregnancy outcomes as well as maternal sera levels of endotoxin, tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-6 were assessed using enzyme-linked immunosorbent assay. It was shown that group B had a higher IL-1β (P = 0.003) and TNF-α (P = 0.003) levels compared to the controls (CTC). Group C expressed a lower gestational duration (P = 0.007) as well as higher IL-6 (P = 0.025) and TNF-α (P |
| doi_str_mv | 10.1016/j.intimp.2020.107081 |
| format | Article |
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The objective of this study was to compare the release of endotoxin and pro-inflammatory cytokines as well as pregnancy outcomes after antibiotic exposure in healthy and bacterial infected pregnant rats. Thirty female Wistar pregnant rats were divided into five groups. Group A considered as control and received intraperitoneal saline 0.9% on 17th day of gestation or DG) and groups B and C treated with 20 mg/kg/day intravenous ceftriaxone and ceftazidime, respectively (DG: 18–20). Groups D and E received intraperitoneal E. coli and LPS on 17th DG respectively. Also, groups F and G received the same treatment as group D but they treated with the exact antibiotics mentioned for groups B and C (same dose and duration). Pregnancy outcomes as well as maternal sera levels of endotoxin, tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-6 were assessed using enzyme-linked immunosorbent assay. It was shown that group B had a higher IL-1β (P = 0.003) and TNF-α (P = 0.003) levels compared to the controls (CTC). Group C expressed a lower gestational duration (P = 0.007) as well as higher IL-6 (P = 0.025) and TNF-α (P < 0.001) levels CTC. Interestingly, both group B (P = 0.021) and C (P < 0.001) had a higher rate of endotoxin release CTC. Moreover, in group C, IL-6 (P < 0.0001 and r = −0.941) had a significant correlation with gestational duration. As the results showed, antibiotic administration in non-indication condition seems to be associated with significantly higher production of endotoxin and inflammatory cytokines which increase the risk of poor pregnancy outcomes.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2020.107081</identifier><identifier>PMID: 33068866</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Intravenous ; Animals ; Animals, Newborn - genetics ; Animals, Newborn - immunology ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - adverse effects ; Antibiotic ; Antibiotics ; Birth Weight - immunology ; Ceftazidime ; Ceftazidime - administration & dosage ; Ceftazidime - adverse effects ; Ceftriaxone ; Ceftriaxone - administration & dosage ; Ceftriaxone - adverse effects ; Cytokines ; E coli ; Endotoxins ; Endotoxins - blood ; Enzyme-linked immunosorbent assay ; Female ; Gene Expression Regulation - immunology ; Gestation ; Gestational Age ; IL-1β ; Inflammation ; Inflammation - etiology ; Interleukin 1 β ; Interleukin 6 ; Interleukin-1beta - blood ; Interleukin-6 - blood ; Intravenous administration ; Lipopolysaccharides ; Pregnancy ; Pregnancy Outcome ; Preterm labor ; Rats, Wistar ; Tumor necrosis factor α ; Tumor Necrosis Factor-alpha - blood ; Tumor necrosis factor-TNF</subject><ispartof>International immunopharmacology, 2020-12, Vol.89 (Pt B), p.107081, Article 107081</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><rights>Copyright Elsevier BV Dec 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-58af45e7ea2b6944986fb2835aa1cb59049c13f4107c0087ab8569e18159c6be3</citedby><cites>FETCH-LOGICAL-c390t-58af45e7ea2b6944986fb2835aa1cb59049c13f4107c0087ab8569e18159c6be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2020.107081$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33068866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghazanfari, Tooba</creatorcontrib><creatorcontrib>Norooznezhad, Amir Hossein</creatorcontrib><creatorcontrib>Javidan, Shima</creatorcontrib><creatorcontrib>Norouz, Leila</creatorcontrib><creatorcontrib>Farzanehdoust, Azadeh</creatorcontrib><creatorcontrib>Mansouri, Kamran</creatorcontrib><creatorcontrib>Ahmadi, Mohammad Hossein</creatorcontrib><creatorcontrib>Mostafaei, Shayan</creatorcontrib><creatorcontrib>Javadian, Pouya</creatorcontrib><creatorcontrib>Sheikh, Mahdi</creatorcontrib><creatorcontrib>Hantoushzadeh, Sedigheh</creatorcontrib><title>Indicated and non-indicated antibiotic administration during pregnancy and its effect on pregnancy outcomes: Role of inflammation</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>•Sterile inflammation is an important etiology of preterm labor.•Some antibiotics could induce pro-inflammatory cytokines in the absence of bacterial infection.•Consumption of some antibiotics in a non-infectious state may cause preterm labor.
The objective of this study was to compare the release of endotoxin and pro-inflammatory cytokines as well as pregnancy outcomes after antibiotic exposure in healthy and bacterial infected pregnant rats. Thirty female Wistar pregnant rats were divided into five groups. Group A considered as control and received intraperitoneal saline 0.9% on 17th day of gestation or DG) and groups B and C treated with 20 mg/kg/day intravenous ceftriaxone and ceftazidime, respectively (DG: 18–20). Groups D and E received intraperitoneal E. coli and LPS on 17th DG respectively. Also, groups F and G received the same treatment as group D but they treated with the exact antibiotics mentioned for groups B and C (same dose and duration). Pregnancy outcomes as well as maternal sera levels of endotoxin, tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-6 were assessed using enzyme-linked immunosorbent assay. It was shown that group B had a higher IL-1β (P = 0.003) and TNF-α (P = 0.003) levels compared to the controls (CTC). Group C expressed a lower gestational duration (P = 0.007) as well as higher IL-6 (P = 0.025) and TNF-α (P < 0.001) levels CTC. Interestingly, both group B (P = 0.021) and C (P < 0.001) had a higher rate of endotoxin release CTC. Moreover, in group C, IL-6 (P < 0.0001 and r = −0.941) had a significant correlation with gestational duration. As the results showed, antibiotic administration in non-indication condition seems to be associated with significantly higher production of endotoxin and inflammatory cytokines which increase the risk of poor pregnancy outcomes.</description><subject>Administration, Intravenous</subject><subject>Animals</subject><subject>Animals, Newborn - genetics</subject><subject>Animals, Newborn - immunology</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Antibiotic</subject><subject>Antibiotics</subject><subject>Birth Weight - immunology</subject><subject>Ceftazidime</subject><subject>Ceftazidime - administration & dosage</subject><subject>Ceftazidime - adverse effects</subject><subject>Ceftriaxone</subject><subject>Ceftriaxone - administration & dosage</subject><subject>Ceftriaxone - adverse effects</subject><subject>Cytokines</subject><subject>E coli</subject><subject>Endotoxins</subject><subject>Endotoxins - blood</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Gene Expression Regulation - immunology</subject><subject>Gestation</subject><subject>Gestational Age</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Interleukin 1 β</subject><subject>Interleukin 6</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukin-6 - blood</subject><subject>Intravenous administration</subject><subject>Lipopolysaccharides</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Preterm labor</subject><subject>Rats, Wistar</subject><subject>Tumor necrosis factor α</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor necrosis factor-TNF</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEuLFTEQhYMozjj6D0QCrvuadHdeLgQZfAwMCKLrkE5XhrrcTq5JWpjl_HNzp8fHylUVJ-ecIh8hLznbccblm_0OY8XluOtZf5IU0_wROeda6Y4rJh63XUjVCSXNGXlWyp6xpo_8KTkbBia1lvKc3F3FGb2rMFMXZxpT7PAfpeKEqaKnbl4wYqnZVUyRzmvGeEOPGW6ii_72Poy1UAgBfKXN8vctrdWnBcpb-jUdgKZAMYaDW5b7rufkSXCHAi8e5gX5_vHDt8vP3fWXT1eX7687PxhWO6FdGAUocP0kzTgaLcPU60E4x_0kDBuN50MYGwjPmFZu0kIa4JoL4-UEwwV5vfUec_qxQql2n9Yc20nbj0r1igtmmmvcXD6nUjIEe8y4uHxrObMn7nZvN-72xN1u3Fvs1UP5Oi0w_wn9Bt0M7zYDtC_-RMi2eIToYcbcgNk54f8v_AKhDpeN</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Ghazanfari, Tooba</creator><creator>Norooznezhad, Amir Hossein</creator><creator>Javidan, Shima</creator><creator>Norouz, Leila</creator><creator>Farzanehdoust, Azadeh</creator><creator>Mansouri, Kamran</creator><creator>Ahmadi, Mohammad Hossein</creator><creator>Mostafaei, Shayan</creator><creator>Javadian, Pouya</creator><creator>Sheikh, Mahdi</creator><creator>Hantoushzadeh, Sedigheh</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>202012</creationdate><title>Indicated and non-indicated antibiotic administration during pregnancy and its effect on pregnancy outcomes: Role of inflammation</title><author>Ghazanfari, Tooba ; Norooznezhad, Amir Hossein ; Javidan, Shima ; Norouz, Leila ; Farzanehdoust, Azadeh ; Mansouri, Kamran ; Ahmadi, Mohammad Hossein ; Mostafaei, Shayan ; Javadian, Pouya ; Sheikh, Mahdi ; Hantoushzadeh, Sedigheh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-58af45e7ea2b6944986fb2835aa1cb59049c13f4107c0087ab8569e18159c6be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Administration, Intravenous</topic><topic>Animals</topic><topic>Animals, Newborn - genetics</topic><topic>Animals, Newborn - immunology</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Antibiotic</topic><topic>Antibiotics</topic><topic>Birth Weight - immunology</topic><topic>Ceftazidime</topic><topic>Ceftazidime - administration & dosage</topic><topic>Ceftazidime - adverse effects</topic><topic>Ceftriaxone</topic><topic>Ceftriaxone - administration & dosage</topic><topic>Ceftriaxone - adverse effects</topic><topic>Cytokines</topic><topic>E coli</topic><topic>Endotoxins</topic><topic>Endotoxins - blood</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Gene Expression Regulation - immunology</topic><topic>Gestation</topic><topic>Gestational Age</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Inflammation - etiology</topic><topic>Interleukin 1 β</topic><topic>Interleukin 6</topic><topic>Interleukin-1beta - blood</topic><topic>Interleukin-6 - blood</topic><topic>Intravenous administration</topic><topic>Lipopolysaccharides</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Preterm labor</topic><topic>Rats, Wistar</topic><topic>Tumor necrosis factor α</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghazanfari, Tooba</creatorcontrib><creatorcontrib>Norooznezhad, Amir Hossein</creatorcontrib><creatorcontrib>Javidan, Shima</creatorcontrib><creatorcontrib>Norouz, Leila</creatorcontrib><creatorcontrib>Farzanehdoust, Azadeh</creatorcontrib><creatorcontrib>Mansouri, Kamran</creatorcontrib><creatorcontrib>Ahmadi, Mohammad Hossein</creatorcontrib><creatorcontrib>Mostafaei, Shayan</creatorcontrib><creatorcontrib>Javadian, Pouya</creatorcontrib><creatorcontrib>Sheikh, Mahdi</creatorcontrib><creatorcontrib>Hantoushzadeh, Sedigheh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghazanfari, Tooba</au><au>Norooznezhad, Amir Hossein</au><au>Javidan, Shima</au><au>Norouz, Leila</au><au>Farzanehdoust, Azadeh</au><au>Mansouri, Kamran</au><au>Ahmadi, Mohammad Hossein</au><au>Mostafaei, Shayan</au><au>Javadian, Pouya</au><au>Sheikh, Mahdi</au><au>Hantoushzadeh, Sedigheh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indicated and non-indicated antibiotic administration during pregnancy and its effect on pregnancy outcomes: Role of inflammation</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2020-12</date><risdate>2020</risdate><volume>89</volume><issue>Pt B</issue><spage>107081</spage><pages>107081-</pages><artnum>107081</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>•Sterile inflammation is an important etiology of preterm labor.•Some antibiotics could induce pro-inflammatory cytokines in the absence of bacterial infection.•Consumption of some antibiotics in a non-infectious state may cause preterm labor.
The objective of this study was to compare the release of endotoxin and pro-inflammatory cytokines as well as pregnancy outcomes after antibiotic exposure in healthy and bacterial infected pregnant rats. Thirty female Wistar pregnant rats were divided into five groups. Group A considered as control and received intraperitoneal saline 0.9% on 17th day of gestation or DG) and groups B and C treated with 20 mg/kg/day intravenous ceftriaxone and ceftazidime, respectively (DG: 18–20). Groups D and E received intraperitoneal E. coli and LPS on 17th DG respectively. Also, groups F and G received the same treatment as group D but they treated with the exact antibiotics mentioned for groups B and C (same dose and duration). Pregnancy outcomes as well as maternal sera levels of endotoxin, tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-6 were assessed using enzyme-linked immunosorbent assay. It was shown that group B had a higher IL-1β (P = 0.003) and TNF-α (P = 0.003) levels compared to the controls (CTC). Group C expressed a lower gestational duration (P = 0.007) as well as higher IL-6 (P = 0.025) and TNF-α (P < 0.001) levels CTC. Interestingly, both group B (P = 0.021) and C (P < 0.001) had a higher rate of endotoxin release CTC. Moreover, in group C, IL-6 (P < 0.0001 and r = −0.941) had a significant correlation with gestational duration. As the results showed, antibiotic administration in non-indication condition seems to be associated with significantly higher production of endotoxin and inflammatory cytokines which increase the risk of poor pregnancy outcomes.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33068866</pmid><doi>10.1016/j.intimp.2020.107081</doi></addata></record> |
| fulltext | fulltext |
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| ispartof | International immunopharmacology, 2020-12, Vol.89 (Pt B), p.107081, Article 107081 |
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| subjects | Administration, Intravenous Animals Animals, Newborn - genetics Animals, Newborn - immunology Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Antibiotic Antibiotics Birth Weight - immunology Ceftazidime Ceftazidime - administration & dosage Ceftazidime - adverse effects Ceftriaxone Ceftriaxone - administration & dosage Ceftriaxone - adverse effects Cytokines E coli Endotoxins Endotoxins - blood Enzyme-linked immunosorbent assay Female Gene Expression Regulation - immunology Gestation Gestational Age IL-1β Inflammation Inflammation - etiology Interleukin 1 β Interleukin 6 Interleukin-1beta - blood Interleukin-6 - blood Intravenous administration Lipopolysaccharides Pregnancy Pregnancy Outcome Preterm labor Rats, Wistar Tumor necrosis factor α Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF |
| title | Indicated and non-indicated antibiotic administration during pregnancy and its effect on pregnancy outcomes: Role of inflammation |
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