Klotho rewires cellular metabolism of breast cancer cells through alteration of calcium shuttling and mitochondrial activity

Klotho is a transmembrane protein, which can be shed and act as a circulating hormone and is involved in regulating cellular calcium levels and inhibition of the PI3K/AKT pathway. As a longevity hormone, it protects normal cells from oxidative stress, and as a tumor suppressor it inhibits growth of...

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Veröffentlicht in:	Oncogene 2020-06, Vol.39 (24), p.4636-4649
Hauptverfasser:	Shmulevich, Riva, Nissim, Tsipi Ben-Kasus, Wolf, Ido, Merenbakh-Lamin, Keren, Fishman, Daniel, Sekler, Israel, Rubinek, Tami
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13/95 14/34 631/443/319/333/1465 631/67/2327 631/80/84 9/10 96/106 Aging AKT protein AMP Animals Apoptosis Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium (mitochondrial) Calcium - metabolism Calcium channels Calcium influx Calcium Signaling Cancer Cancer cells Care and treatment Cell Biology Glucose metabolism Glucuronidase - genetics Glucuronidase - metabolism Glycolysis Human Genetics Humans Internal Medicine Klotho protein LKB1 protein MCF-7 Cells Medicine Medicine & Public Health Membrane potential Metabolic pathways Metabolism Mice Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncology Oxidative stress Phosphorylation Physiological aspects Tricarboxylic acid cycle Tumor suppressor genes
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