MAOA-mediated reprogramming of stromal fibroblasts promotes prostate tumorigenesis and cancer stemness

The tumor microenvironment plays a critical role in prostate cancer (PC) development and progression. Inappropriate activation of the stroma potentiates the growth and transformation of epithelial tumor cells. Here, we show that upregulation of monoamine oxidase A (MAOA), a mitochondrial enzyme that...

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Veröffentlicht in:	Oncogene 2020-04, Vol.39 (16), p.3305-3321
Hauptverfasser:	Li, Jingjing, Pu, Tianjie, Yin, Lijuan, Li, Qinlong, Liao, Chun-Peng, Wu, Boyang Jason
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/105 13/21 13/31 13/51 13/95 59/5 631/67/327 631/67/589/466 64/60 Amine oxidase (flavin-containing) Animals Apoptosis Cancer Carcinogenesis - drug effects Carcinogenesis - genetics Care and treatment CD44 antigen Cell Biology Cell Proliferation - drug effects Cellular Reprogramming - drug effects Cellular Reprogramming - genetics Development and progression DNA microarrays Enzymes Fibroblasts Fibroblasts - drug effects Genetic aspects Health aspects Heterografts Human Genetics Humans Immune response Inflammation Interleukin 6 Interleukin-6 - genetics Internal Medicine Male Medicine Medicine & Public Health Mice Mitochondria Monoamine Oxidase - genetics Monoamine Oxidase Inhibitors - pharmacology Monoamines Neurotransmitters Nuclear Proteins - genetics Oncology Oxidases Paracrine signalling Pheochromocytoma cells Prostate Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Reactive oxygen species Regulation Stat3 protein STAT3 Transcription Factor - genetics Stem cells Stromal cells Transcription Tumor cells Tumor microenvironment Tumor Microenvironment - drug effects Tumor Microenvironment - genetics Tumorigenesis Twist-Related Protein 1 - genetics
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