Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling

Histone demethylase JMJD2D can promote gene expression by specifically demethylating H3K9me2/3. The role of JMJD2D in colitis and colitis-associated colorectal cancer (CRC) progression remains unclear. Here, we show that colonic JMJD2D is induced by TNFα during dextran sulfate sodium-induced colitis...

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Veröffentlicht in:	Oncogene 2020-04, Vol.39 (16), p.3336-3353
Hauptverfasser:	Zhuo, Minghui, Chen, Wenbo, Shang, Shaohui, Guo, Peng, Peng, Kesong, Li, Ming, Mo, Pingli, Zhang, Yongyou, Qiu, Xingfeng, Li, Wengang, Yu, Chundong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/2 13/51 13/89 45/15 631/250/256 631/67/1504/1885 64/60 82/83 96/106 Anilides - pharmacology Animals Apoptosis Aspirin Aspirin - pharmacology Carcinogenesis - drug effects Care and treatment Cell Biology Cell proliferation Cell Proliferation - drug effects Cellular signal transduction Colitis Colitis - drug therapy Colitis - genetics Colitis - pathology Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Complications and side effects Development and progression Dextran Dextran sulfate Disease Models, Animal Drug Synergism Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques Genetic aspects Health aspects Hedgehog protein Hedgehog proteins Hedgehog Proteins - antagonists & inhibitors Hedgehog Proteins - genetics Histones Human Genetics Humans Inflammation - drug therapy Inflammation - genetics Inflammation - pathology Inflammatory bowel disease Inflammatory bowel diseases Internal Medicine Intestine Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors Jumonji Domain-Containing Histone Demethylases - genetics Medicine Medicine & Public Health Metastases Mice Oncology Pyridines - pharmacology Signal Transduction - drug effects Signal Transduction - genetics Tumor necrosis factor Tumor necrosis factor-α Tumorigenesis
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