Bptf determines oncogenic addiction in aggressive B-cell lymphomas

Chromatin remodeling factors contribute to establish aberrant gene expression programs in cancer cells and therefore represent valuable targets for therapeutic intervention. BPTF (Bromodomain PhD Transcription Factor), a core subunit of the nucleosome remodeling factor (NURF), modulates c-MYC oncoge...

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Veröffentlicht in:	Oncogene 2020-06, Vol.39 (25), p.4884-4895
Hauptverfasser:	Richart, Laia, Felipe, Irene, Delgado, Pilar, Andrés, Mónica P. de, Prieto, Jaime, Pozo, Natalia del, García, Juan F., Piris, Miguel A., Ramiro, Almudena, Real, Francisco X.
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/91 631/208/200 631/67/1990/291/1621 64/60 82 82/80 Addictions Analysis Animals Antigens, Nuclear - genetics Antigens, Nuclear - metabolism Apoptosis B cells B-cell lymphoma B-Lymphocytes - metabolism Beta cells c-Myc protein Cancer Carcinogenesis - genetics Cell Biology Cell differentiation Chromatin Chromatin Assembly and Disassembly - genetics Chromatin remodeling Development and progression Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genetic engineering Haploinsufficiency Health aspects Human Genetics Humans Internal Medicine Kinases Lymphoma Lymphoma, B-Cell - genetics Lymphoma, B-Cell - metabolism Medicine Medicine & Public Health Mice, Knockout Mice, Transgenic Myc protein Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Non-Hodgkin's lymphomas Nucleosome remodeling factor Oncogene Addiction - genetics Oncology Pancreatic cancer Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Rodents Signal Transduction - genetics Therapeutic applications Therapeutic targets Transcription Factors - genetics Transcription Factors - metabolism Transgenic mice Tumors
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