Sox2‐dependent maintenance of mouse oligodendroglioma involves the Sox2‐mediated downregulation of Cdkn2b, Ebf1, Zfp423, and Hey2

Cancer stem cells (CSC) are essential for tumorigenesis. The transcription factor Sox2 is overexpressed in brain gliomas, and is essential to maintain CSC. In mouse high‐grade glioma pHGG cells in culture, Sox2 deletion causes cell proliferation arrest and inability to reform tumors after transplant...

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Veröffentlicht in:	Glia 2021-03, Vol.69 (3), p.579-593
Hauptverfasser:	Barone, Cristiana, Buccarelli, Mariachiara, Alessandrini, Francesco, Pagin, Miriam, Rigoldi, Laura, Sambruni, Irene, Favaro, Rebecca, Ottolenghi, Sergio, Pallini, Roberto, Ricci‐Vitiani, Lucia, Malatesta, Paolo, Nicolis, Silvia K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors Brain Brain cancer Brain Neoplasms - genetics Brain tumors cancer stem cells Carcinogenesis - genetics Cell culture Cell growth Cell Line, Tumor Cell proliferation Clonal deletion CRISPR Deletion Down-Regulation gene regulatory networks Genes Glioblastoma Glioma - genetics Glioma cells human glioblastoma Maintenance Mice mouse oligodendroglioma Mutagenesis Neoplastic Stem Cells - metabolism Oligodendroglioma Repressor Proteins Sox2 SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Stem cell transplantation Stem cells Therapeutic targets Trans-Activators transcription factors Transplantation Tumorigenesis Tumors
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