The silent presence of Mycoplasma hominis in patients with prostate cancer
ABSTRACT Background Mycoplasma hominis, an opportunistic pathogen in human genitourinary tract, can cause chronic infection in the prostate. Intracellular survival of M. hominis leads to a prolonged presence in the host cells that can affect the cell's biological cycle. In the present study, we...
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| Veröffentlicht in: | Pathogens and Disease 2020-10, Vol.78 (7), p.1 |
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| creator | Saadat, Saman Karami, Pezhman Jafari, Mohammad Kholoujini, Mahdi Rikhtegaran Tehrani, Zahra Mohammadi, Younes Alikhani, Mohammad Yousef |
| description | ABSTRACT
Background
Mycoplasma hominis, an opportunistic pathogen in human genitourinary tract, can cause chronic infection in the prostate. Intracellular survival of M. hominis leads to a prolonged presence in the host cells that can affect the cell's biological cycle. In the present study, we aimed to evaluate the frequency of M. hominis DNA in prostate tissue of Iranian patients with prostate cancer (PCa) in comparison to a control group with benign prostatic hyperplasia (BPH).
Methods
This research was a retrospective case-control study using 61 archived formalin-fixed paraffin-embedded (FFPE) blocks of prostate tissue from patients with PCa and 70 FFPE blocks of patients with BPH. Real-time PCR, targeting two different genes, 16S rRNA and yidC, in the M. hominis genome was performed for all specimens.
Results
Out of 61 blocks of prostate biopsy from patients with PCa, eight samples (13%) were positive for M. hominis, while the bacterium was not detected in any of the 70 blocks of patients with BPH (P value, 0.002).
Conclusions
The high frequency of M. hominis in patients with PCa likely shows a hidden role of the organism in prostate cancer during its chronic, apparently silent and asymptomatic colonization in prostate.
The clinical importance of Mycoplasma hominis, a fastidious bacterium in the human genitourinary tract, was evaluated in Iranian patients with prostate cancer in comparison to patients with benign prostatic hyperplasia. |
| doi_str_mv | 10.1093/femspd/ftaa037 |
| format | Article |
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Background
Mycoplasma hominis, an opportunistic pathogen in human genitourinary tract, can cause chronic infection in the prostate. Intracellular survival of M. hominis leads to a prolonged presence in the host cells that can affect the cell's biological cycle. In the present study, we aimed to evaluate the frequency of M. hominis DNA in prostate tissue of Iranian patients with prostate cancer (PCa) in comparison to a control group with benign prostatic hyperplasia (BPH).
Methods
This research was a retrospective case-control study using 61 archived formalin-fixed paraffin-embedded (FFPE) blocks of prostate tissue from patients with PCa and 70 FFPE blocks of patients with BPH. Real-time PCR, targeting two different genes, 16S rRNA and yidC, in the M. hominis genome was performed for all specimens.
Results
Out of 61 blocks of prostate biopsy from patients with PCa, eight samples (13%) were positive for M. hominis, while the bacterium was not detected in any of the 70 blocks of patients with BPH (P value, 0.002).
Conclusions
The high frequency of M. hominis in patients with PCa likely shows a hidden role of the organism in prostate cancer during its chronic, apparently silent and asymptomatic colonization in prostate.
The clinical importance of Mycoplasma hominis, a fastidious bacterium in the human genitourinary tract, was evaluated in Iranian patients with prostate cancer in comparison to patients with benign prostatic hyperplasia.</description><identifier>ISSN: 2049-632X</identifier><identifier>EISSN: 2049-632X</identifier><identifier>DOI: 10.1093/femspd/ftaa037</identifier><identifier>PMID: 32940669</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Biopsy ; Chronic infection ; Colonization ; Deoxyribonucleic acid ; Diagnosis ; DNA ; Genitourinary tract ; Genomes ; Growth ; Health aspects ; Hyperplasia ; Mycoplasma ; Mycoplasma hominis ; Opportunist infection ; Paraffin ; Paraffins ; Prostate cancer ; rRNA 16S ; Testing</subject><ispartof>Pathogens and Disease, 2020-10, Vol.78 (7), p.1</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of FEMS. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of FEMS.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-99e594baa06735f44c1861401b3f1c13093aecfa90cb6023e190a792dbeea9863</citedby><cites>FETCH-LOGICAL-c424t-99e594baa06735f44c1861401b3f1c13093aecfa90cb6023e190a792dbeea9863</cites><orcidid>0000-0001-9851-7638</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1604,27924,27925</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/femspd/ftaa037$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32940669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saadat, Saman</creatorcontrib><creatorcontrib>Karami, Pezhman</creatorcontrib><creatorcontrib>Jafari, Mohammad</creatorcontrib><creatorcontrib>Kholoujini, Mahdi</creatorcontrib><creatorcontrib>Rikhtegaran Tehrani, Zahra</creatorcontrib><creatorcontrib>Mohammadi, Younes</creatorcontrib><creatorcontrib>Alikhani, Mohammad Yousef</creatorcontrib><title>The silent presence of Mycoplasma hominis in patients with prostate cancer</title><title>Pathogens and Disease</title><addtitle>Pathog Dis</addtitle><description>ABSTRACT
Background
Mycoplasma hominis, an opportunistic pathogen in human genitourinary tract, can cause chronic infection in the prostate. Intracellular survival of M. hominis leads to a prolonged presence in the host cells that can affect the cell's biological cycle. In the present study, we aimed to evaluate the frequency of M. hominis DNA in prostate tissue of Iranian patients with prostate cancer (PCa) in comparison to a control group with benign prostatic hyperplasia (BPH).
Methods
This research was a retrospective case-control study using 61 archived formalin-fixed paraffin-embedded (FFPE) blocks of prostate tissue from patients with PCa and 70 FFPE blocks of patients with BPH. Real-time PCR, targeting two different genes, 16S rRNA and yidC, in the M. hominis genome was performed for all specimens.
Results
Out of 61 blocks of prostate biopsy from patients with PCa, eight samples (13%) were positive for M. hominis, while the bacterium was not detected in any of the 70 blocks of patients with BPH (P value, 0.002).
Conclusions
The high frequency of M. hominis in patients with PCa likely shows a hidden role of the organism in prostate cancer during its chronic, apparently silent and asymptomatic colonization in prostate.
The clinical importance of Mycoplasma hominis, a fastidious bacterium in the human genitourinary tract, was evaluated in Iranian patients with prostate cancer in comparison to patients with benign prostatic hyperplasia.</description><subject>Biopsy</subject><subject>Chronic infection</subject><subject>Colonization</subject><subject>Deoxyribonucleic acid</subject><subject>Diagnosis</subject><subject>DNA</subject><subject>Genitourinary tract</subject><subject>Genomes</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Hyperplasia</subject><subject>Mycoplasma</subject><subject>Mycoplasma hominis</subject><subject>Opportunist infection</subject><subject>Paraffin</subject><subject>Paraffins</subject><subject>Prostate cancer</subject><subject>rRNA 16S</subject><subject>Testing</subject><issn>2049-632X</issn><issn>2049-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkLtPwzAQxi0EolXpyogsMTGk2LHrxGNV8VQRS5HYLMc5U1d5EbtC_e8xSnlsnIfz8Pvu7vsQOqdkRolk1xZq35XXNmhNWHaExinhMhEsfT3-8x-hqfdbEiuf0zwTp2jEUsmJEHKMHtcbwN5V0ATc9eChMYBbi5_2pu0q7WuNN23tGuexa3Cng4ukxx8ubCLf-qADYKOjqj9DJ1ZXHqaHPkEvtzfr5X2yer57WC5WieEpD4mUMJe8iCeLjM0t54bmgnJCC2apoSwa02CslsQUgqQMqCQ6k2lZAGiZCzZBl8PcuP99Bz6obbvrm7hSpTwTVEQ4i9RsoN50Bco1tg29NvGVUDvTNmCjabUQknBOU5r_Cky05Xuwqutdrfu9okR9xa2GuNUh7ii4ONyxK2oof_DvcCNwNQDtrvtv2Cc5HIsA</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Saadat, Saman</creator><creator>Karami, Pezhman</creator><creator>Jafari, Mohammad</creator><creator>Kholoujini, Mahdi</creator><creator>Rikhtegaran Tehrani, Zahra</creator><creator>Mohammadi, Younes</creator><creator>Alikhani, Mohammad Yousef</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7T7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0001-9851-7638</orcidid></search><sort><creationdate>20201001</creationdate><title>The silent presence of Mycoplasma hominis in patients with prostate cancer</title><author>Saadat, Saman ; Karami, Pezhman ; Jafari, Mohammad ; Kholoujini, Mahdi ; Rikhtegaran Tehrani, Zahra ; Mohammadi, Younes ; Alikhani, Mohammad Yousef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-99e594baa06735f44c1861401b3f1c13093aecfa90cb6023e190a792dbeea9863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biopsy</topic><topic>Chronic infection</topic><topic>Colonization</topic><topic>Deoxyribonucleic acid</topic><topic>Diagnosis</topic><topic>DNA</topic><topic>Genitourinary tract</topic><topic>Genomes</topic><topic>Growth</topic><topic>Health aspects</topic><topic>Hyperplasia</topic><topic>Mycoplasma</topic><topic>Mycoplasma hominis</topic><topic>Opportunist infection</topic><topic>Paraffin</topic><topic>Paraffins</topic><topic>Prostate cancer</topic><topic>rRNA 16S</topic><topic>Testing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saadat, Saman</creatorcontrib><creatorcontrib>Karami, Pezhman</creatorcontrib><creatorcontrib>Jafari, Mohammad</creatorcontrib><creatorcontrib>Kholoujini, Mahdi</creatorcontrib><creatorcontrib>Rikhtegaran Tehrani, Zahra</creatorcontrib><creatorcontrib>Mohammadi, Younes</creatorcontrib><creatorcontrib>Alikhani, Mohammad Yousef</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Pathogens and Disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Saadat, Saman</au><au>Karami, Pezhman</au><au>Jafari, Mohammad</au><au>Kholoujini, Mahdi</au><au>Rikhtegaran Tehrani, Zahra</au><au>Mohammadi, Younes</au><au>Alikhani, Mohammad Yousef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The silent presence of Mycoplasma hominis in patients with prostate cancer</atitle><jtitle>Pathogens and Disease</jtitle><addtitle>Pathog Dis</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>78</volume><issue>7</issue><spage>1</spage><pages>1-</pages><issn>2049-632X</issn><eissn>2049-632X</eissn><abstract>ABSTRACT
Background
Mycoplasma hominis, an opportunistic pathogen in human genitourinary tract, can cause chronic infection in the prostate. Intracellular survival of M. hominis leads to a prolonged presence in the host cells that can affect the cell's biological cycle. In the present study, we aimed to evaluate the frequency of M. hominis DNA in prostate tissue of Iranian patients with prostate cancer (PCa) in comparison to a control group with benign prostatic hyperplasia (BPH).
Methods
This research was a retrospective case-control study using 61 archived formalin-fixed paraffin-embedded (FFPE) blocks of prostate tissue from patients with PCa and 70 FFPE blocks of patients with BPH. Real-time PCR, targeting two different genes, 16S rRNA and yidC, in the M. hominis genome was performed for all specimens.
Results
Out of 61 blocks of prostate biopsy from patients with PCa, eight samples (13%) were positive for M. hominis, while the bacterium was not detected in any of the 70 blocks of patients with BPH (P value, 0.002).
Conclusions
The high frequency of M. hominis in patients with PCa likely shows a hidden role of the organism in prostate cancer during its chronic, apparently silent and asymptomatic colonization in prostate.
The clinical importance of Mycoplasma hominis, a fastidious bacterium in the human genitourinary tract, was evaluated in Iranian patients with prostate cancer in comparison to patients with benign prostatic hyperplasia.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>32940669</pmid><doi>10.1093/femspd/ftaa037</doi><orcidid>https://orcid.org/0000-0001-9851-7638</orcidid></addata></record> |
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| subjects | Biopsy Chronic infection Colonization Deoxyribonucleic acid Diagnosis DNA Genitourinary tract Genomes Growth Health aspects Hyperplasia Mycoplasma Mycoplasma hominis Opportunist infection Paraffin Paraffins Prostate cancer rRNA 16S Testing |
| title | The silent presence of Mycoplasma hominis in patients with prostate cancer |
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