Lactational exposure to phthalate monoesters among breastfed infants in Italy
Abstract Background Phthalates are chemicals widely used as additives in plastics, cosmetics and medical devices. Due to their endocrine disrupting action and ubiquitous environmental presence, the detection of their levels in breast milk is a crucial public health issue. However, up to date limited...
Gespeichert in:
| Veröffentlicht in: | European journal of public health 2020-09, Vol.30 (Supplement_5) |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | Supplement_5 |
| container_start_page | |
| container_title | European journal of public health |
| container_volume | 30 |
| creator | Arletti, M Maione, D Fioretti, E Panciroli, G Predieri, G Pinetti, D Bargellini, A Facchinetti, F Fantuzzi, G Righi, E |
| description | Abstract
Background
Phthalates are chemicals widely used as additives in plastics, cosmetics and medical devices. Due to their endocrine disrupting action and ubiquitous environmental presence, the detection of their levels in breast milk is a crucial public health issue. However, up to date limited information exists on lactational exposure to phthalates in Italy. We aimed to determine the levels of 6 phthalate monoesters in breast milk of women living in Modena (Italy), to investigate the potential sources of exposure and to calculate the Estimated Daily Intake (EDI) for breastfed infants.
Methods
In this cross-sectional study 201 women (19-45 years) living in Modena (Northern Italy) provided a sample of breast milk (30-40 days postpartum) and filled in a questionnaire on personal data and on potential sources of exposure to phthalates. Samples were analyzed by triple Quad LC/MS Mass Spectrometry. Phthalates levels were used to calculate newborns' EDIs that were compared with the Tolerable Daily Intake (TDI) set up by the European Food Safety Authority (EFSA).
Results
Monoethyl phthalate (MEP) and monoisononyl phthalate (MiNP) were detected in most samples, respectively, in 173 (86%; mean: 14.50±80.88; range: 0.03-674 μg/l) and 160 samples (80%; mean: 1.41±2.48; range: 0.04-18.40 μg/l). Levels appeared higher in women more frequently consuming food and beverages preserved in plastic containers or using cosmetics, although differences were not significant. The EDI levels for MEP (mean: 2.08±11.39 µg/kg BW/day) and MiNP (mean: 0.20±0.33 µg/kg BW/day) appeared below the TDI values set up by EFSA.
Conclusions
Although the widespread diffusion of phthalate monoesters in breast milk, their levels resulted lower than those reported in other studies and the EFSA recommended values. Thus, the use of breast milk, a unique nourishment for infants, should not be discouraged.
Key messages
Monitoring phthalates’ levels in breast milk is crucial to check breastfed infants’ exposure and to prevent potential health risks associated with this exposure.
It’s essential to adopt effective public health interventions to reduce phthalates dissemination in environment and food and consequently the maternal and infant exposure to these contaminants. |
| doi_str_mv | 10.1093/eurpub/ckaa166.955 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2476160763</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/eurpub/ckaa166.955</oup_id><sourcerecordid>2476160763</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2025-71bd2f8bb9c5d76191f341511a96828b761842300f70c31b8556255655de574f3</originalsourceid><addsrcrecordid>eNqNkE1OwzAQhS0EEqVwAVaWWKf12LGTLFHFT6UiNiCxsyaJTVvSONiORG-PUXoAFqM3Gr03mvkIuQW2AFaJpRn9MNbL5gsRlFpUUp6RGeQqz4RiH-epBwYZcMUvyVUIe8aYLEo-Iy8bbCLGneuxo-ZncGH0hkZHh23cYofR0IPrnQnR-EAx9Z-09gZDtKalu95iH0NSuo7YHa_JhcUumJuTzsn748Pb6jnbvD6tV_ebrOGMy6yAuuW2rOuqkW2hoAIrcpAAWKmSl3UalTkXjNmCNQLqUkrFU0nZGlnkVszJ3bR38O57TMfpvRt9eiFonqe0YoUSycUnV-NdCN5YPfjdAf1RA9N_2PSETZ-w6YQthbIp5MbhP_5f40pxzg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2476160763</pqid></control><display><type>article</type><title>Lactational exposure to phthalate monoesters among breastfed infants in Italy</title><source>Oxford Journals Open Access Collection</source><source>PAIS Index</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Sociological Abstracts</source><creator>Arletti, M ; Maione, D ; Fioretti, E ; Panciroli, G ; Predieri, G ; Pinetti, D ; Bargellini, A ; Facchinetti, F ; Fantuzzi, G ; Righi, E</creator><creatorcontrib>Arletti, M ; Maione, D ; Fioretti, E ; Panciroli, G ; Predieri, G ; Pinetti, D ; Bargellini, A ; Facchinetti, F ; Fantuzzi, G ; Righi, E</creatorcontrib><description>Abstract
Background
Phthalates are chemicals widely used as additives in plastics, cosmetics and medical devices. Due to their endocrine disrupting action and ubiquitous environmental presence, the detection of their levels in breast milk is a crucial public health issue. However, up to date limited information exists on lactational exposure to phthalates in Italy. We aimed to determine the levels of 6 phthalate monoesters in breast milk of women living in Modena (Italy), to investigate the potential sources of exposure and to calculate the Estimated Daily Intake (EDI) for breastfed infants.
Methods
In this cross-sectional study 201 women (19-45 years) living in Modena (Northern Italy) provided a sample of breast milk (30-40 days postpartum) and filled in a questionnaire on personal data and on potential sources of exposure to phthalates. Samples were analyzed by triple Quad LC/MS Mass Spectrometry. Phthalates levels were used to calculate newborns' EDIs that were compared with the Tolerable Daily Intake (TDI) set up by the European Food Safety Authority (EFSA).
Results
Monoethyl phthalate (MEP) and monoisononyl phthalate (MiNP) were detected in most samples, respectively, in 173 (86%; mean: 14.50±80.88; range: 0.03-674 μg/l) and 160 samples (80%; mean: 1.41±2.48; range: 0.04-18.40 μg/l). Levels appeared higher in women more frequently consuming food and beverages preserved in plastic containers or using cosmetics, although differences were not significant. The EDI levels for MEP (mean: 2.08±11.39 µg/kg BW/day) and MiNP (mean: 0.20±0.33 µg/kg BW/day) appeared below the TDI values set up by EFSA.
Conclusions
Although the widespread diffusion of phthalate monoesters in breast milk, their levels resulted lower than those reported in other studies and the EFSA recommended values. Thus, the use of breast milk, a unique nourishment for infants, should not be discouraged.
Key messages
Monitoring phthalates’ levels in breast milk is crucial to check breastfed infants’ exposure and to prevent potential health risks associated with this exposure.
It’s essential to adopt effective public health interventions to reduce phthalates dissemination in environment and food and consequently the maternal and infant exposure to these contaminants.</description><identifier>ISSN: 1101-1262</identifier><identifier>EISSN: 1464-360X</identifier><identifier>DOI: 10.1093/eurpub/ckaa166.955</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Additives ; Baby foods ; Beverages ; Breast milk ; Breastfeeding & lactation ; Chemicals ; Containers ; Contaminants ; Cosmetics ; Cross-sectional studies ; Endocrine disruptors ; Exposure ; Food ; Food consumption ; Food contamination & poisoning ; Food safety ; Health risks ; Hormones ; Infants ; Information dissemination ; Mass spectrometry ; Mass spectroscopy ; Maternal and infant welfare ; Mathematical analysis ; Medical equipment ; Medicine ; Milk ; Neonates ; Phthalates ; Pollution monitoring ; Polymers ; Postpartum ; Public health ; Women</subject><ispartof>European journal of public health, 2020-09, Vol.30 (Supplement_5)</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2025-71bd2f8bb9c5d76191f341511a96828b761842300f70c31b8556255655de574f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27843,27901,27902,33751</link.rule.ids></links><search><creatorcontrib>Arletti, M</creatorcontrib><creatorcontrib>Maione, D</creatorcontrib><creatorcontrib>Fioretti, E</creatorcontrib><creatorcontrib>Panciroli, G</creatorcontrib><creatorcontrib>Predieri, G</creatorcontrib><creatorcontrib>Pinetti, D</creatorcontrib><creatorcontrib>Bargellini, A</creatorcontrib><creatorcontrib>Facchinetti, F</creatorcontrib><creatorcontrib>Fantuzzi, G</creatorcontrib><creatorcontrib>Righi, E</creatorcontrib><title>Lactational exposure to phthalate monoesters among breastfed infants in Italy</title><title>European journal of public health</title><description>Abstract
Background
Phthalates are chemicals widely used as additives in plastics, cosmetics and medical devices. Due to their endocrine disrupting action and ubiquitous environmental presence, the detection of their levels in breast milk is a crucial public health issue. However, up to date limited information exists on lactational exposure to phthalates in Italy. We aimed to determine the levels of 6 phthalate monoesters in breast milk of women living in Modena (Italy), to investigate the potential sources of exposure and to calculate the Estimated Daily Intake (EDI) for breastfed infants.
Methods
In this cross-sectional study 201 women (19-45 years) living in Modena (Northern Italy) provided a sample of breast milk (30-40 days postpartum) and filled in a questionnaire on personal data and on potential sources of exposure to phthalates. Samples were analyzed by triple Quad LC/MS Mass Spectrometry. Phthalates levels were used to calculate newborns' EDIs that were compared with the Tolerable Daily Intake (TDI) set up by the European Food Safety Authority (EFSA).
Results
Monoethyl phthalate (MEP) and monoisononyl phthalate (MiNP) were detected in most samples, respectively, in 173 (86%; mean: 14.50±80.88; range: 0.03-674 μg/l) and 160 samples (80%; mean: 1.41±2.48; range: 0.04-18.40 μg/l). Levels appeared higher in women more frequently consuming food and beverages preserved in plastic containers or using cosmetics, although differences were not significant. The EDI levels for MEP (mean: 2.08±11.39 µg/kg BW/day) and MiNP (mean: 0.20±0.33 µg/kg BW/day) appeared below the TDI values set up by EFSA.
Conclusions
Although the widespread diffusion of phthalate monoesters in breast milk, their levels resulted lower than those reported in other studies and the EFSA recommended values. Thus, the use of breast milk, a unique nourishment for infants, should not be discouraged.
Key messages
Monitoring phthalates’ levels in breast milk is crucial to check breastfed infants’ exposure and to prevent potential health risks associated with this exposure.
It’s essential to adopt effective public health interventions to reduce phthalates dissemination in environment and food and consequently the maternal and infant exposure to these contaminants.</description><subject>Additives</subject><subject>Baby foods</subject><subject>Beverages</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Chemicals</subject><subject>Containers</subject><subject>Contaminants</subject><subject>Cosmetics</subject><subject>Cross-sectional studies</subject><subject>Endocrine disruptors</subject><subject>Exposure</subject><subject>Food</subject><subject>Food consumption</subject><subject>Food contamination & poisoning</subject><subject>Food safety</subject><subject>Health risks</subject><subject>Hormones</subject><subject>Infants</subject><subject>Information dissemination</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Maternal and infant welfare</subject><subject>Mathematical analysis</subject><subject>Medical equipment</subject><subject>Medicine</subject><subject>Milk</subject><subject>Neonates</subject><subject>Phthalates</subject><subject>Pollution monitoring</subject><subject>Polymers</subject><subject>Postpartum</subject><subject>Public health</subject><subject>Women</subject><issn>1101-1262</issn><issn>1464-360X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>7TQ</sourceid><sourceid>BHHNA</sourceid><recordid>eNqNkE1OwzAQhS0EEqVwAVaWWKf12LGTLFHFT6UiNiCxsyaJTVvSONiORG-PUXoAFqM3Gr03mvkIuQW2AFaJpRn9MNbL5gsRlFpUUp6RGeQqz4RiH-epBwYZcMUvyVUIe8aYLEo-Iy8bbCLGneuxo-ZncGH0hkZHh23cYofR0IPrnQnR-EAx9Z-09gZDtKalu95iH0NSuo7YHa_JhcUumJuTzsn748Pb6jnbvD6tV_ebrOGMy6yAuuW2rOuqkW2hoAIrcpAAWKmSl3UalTkXjNmCNQLqUkrFU0nZGlnkVszJ3bR38O57TMfpvRt9eiFonqe0YoUSycUnV-NdCN5YPfjdAf1RA9N_2PSETZ-w6YQthbIp5MbhP_5f40pxzg</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Arletti, M</creator><creator>Maione, D</creator><creator>Fioretti, E</creator><creator>Panciroli, G</creator><creator>Predieri, G</creator><creator>Pinetti, D</creator><creator>Bargellini, A</creator><creator>Facchinetti, F</creator><creator>Fantuzzi, G</creator><creator>Righi, E</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TQ</scope><scope>7U3</scope><scope>BHHNA</scope><scope>C1K</scope><scope>DHY</scope><scope>DON</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20200901</creationdate><title>Lactational exposure to phthalate monoesters among breastfed infants in Italy</title><author>Arletti, M ; Maione, D ; Fioretti, E ; Panciroli, G ; Predieri, G ; Pinetti, D ; Bargellini, A ; Facchinetti, F ; Fantuzzi, G ; Righi, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2025-71bd2f8bb9c5d76191f341511a96828b761842300f70c31b8556255655de574f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Additives</topic><topic>Baby foods</topic><topic>Beverages</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Chemicals</topic><topic>Containers</topic><topic>Contaminants</topic><topic>Cosmetics</topic><topic>Cross-sectional studies</topic><topic>Endocrine disruptors</topic><topic>Exposure</topic><topic>Food</topic><topic>Food consumption</topic><topic>Food contamination & poisoning</topic><topic>Food safety</topic><topic>Health risks</topic><topic>Hormones</topic><topic>Infants</topic><topic>Information dissemination</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Maternal and infant welfare</topic><topic>Mathematical analysis</topic><topic>Medical equipment</topic><topic>Medicine</topic><topic>Milk</topic><topic>Neonates</topic><topic>Phthalates</topic><topic>Pollution monitoring</topic><topic>Polymers</topic><topic>Postpartum</topic><topic>Public health</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arletti, M</creatorcontrib><creatorcontrib>Maione, D</creatorcontrib><creatorcontrib>Fioretti, E</creatorcontrib><creatorcontrib>Panciroli, G</creatorcontrib><creatorcontrib>Predieri, G</creatorcontrib><creatorcontrib>Pinetti, D</creatorcontrib><creatorcontrib>Bargellini, A</creatorcontrib><creatorcontrib>Facchinetti, F</creatorcontrib><creatorcontrib>Fantuzzi, G</creatorcontrib><creatorcontrib>Righi, E</creatorcontrib><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>PAIS Index</collection><collection>Social Services Abstracts</collection><collection>Sociological Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PAIS International</collection><collection>PAIS International (Ovid)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>European journal of public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arletti, M</au><au>Maione, D</au><au>Fioretti, E</au><au>Panciroli, G</au><au>Predieri, G</au><au>Pinetti, D</au><au>Bargellini, A</au><au>Facchinetti, F</au><au>Fantuzzi, G</au><au>Righi, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactational exposure to phthalate monoesters among breastfed infants in Italy</atitle><jtitle>European journal of public health</jtitle><date>2020-09-01</date><risdate>2020</risdate><volume>30</volume><issue>Supplement_5</issue><issn>1101-1262</issn><eissn>1464-360X</eissn><abstract>Abstract
Background
Phthalates are chemicals widely used as additives in plastics, cosmetics and medical devices. Due to their endocrine disrupting action and ubiquitous environmental presence, the detection of their levels in breast milk is a crucial public health issue. However, up to date limited information exists on lactational exposure to phthalates in Italy. We aimed to determine the levels of 6 phthalate monoesters in breast milk of women living in Modena (Italy), to investigate the potential sources of exposure and to calculate the Estimated Daily Intake (EDI) for breastfed infants.
Methods
In this cross-sectional study 201 women (19-45 years) living in Modena (Northern Italy) provided a sample of breast milk (30-40 days postpartum) and filled in a questionnaire on personal data and on potential sources of exposure to phthalates. Samples were analyzed by triple Quad LC/MS Mass Spectrometry. Phthalates levels were used to calculate newborns' EDIs that were compared with the Tolerable Daily Intake (TDI) set up by the European Food Safety Authority (EFSA).
Results
Monoethyl phthalate (MEP) and monoisononyl phthalate (MiNP) were detected in most samples, respectively, in 173 (86%; mean: 14.50±80.88; range: 0.03-674 μg/l) and 160 samples (80%; mean: 1.41±2.48; range: 0.04-18.40 μg/l). Levels appeared higher in women more frequently consuming food and beverages preserved in plastic containers or using cosmetics, although differences were not significant. The EDI levels for MEP (mean: 2.08±11.39 µg/kg BW/day) and MiNP (mean: 0.20±0.33 µg/kg BW/day) appeared below the TDI values set up by EFSA.
Conclusions
Although the widespread diffusion of phthalate monoesters in breast milk, their levels resulted lower than those reported in other studies and the EFSA recommended values. Thus, the use of breast milk, a unique nourishment for infants, should not be discouraged.
Key messages
Monitoring phthalates’ levels in breast milk is crucial to check breastfed infants’ exposure and to prevent potential health risks associated with this exposure.
It’s essential to adopt effective public health interventions to reduce phthalates dissemination in environment and food and consequently the maternal and infant exposure to these contaminants.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1093/eurpub/ckaa166.955</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1101-1262 |
| ispartof | European journal of public health, 2020-09, Vol.30 (Supplement_5) |
| issn | 1101-1262 1464-360X |
| language | eng |
| recordid | cdi_proquest_journals_2476160763 |
| source | Oxford Journals Open Access Collection; PAIS Index; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Sociological Abstracts |
| subjects | Additives Baby foods Beverages Breast milk Breastfeeding & lactation Chemicals Containers Contaminants Cosmetics Cross-sectional studies Endocrine disruptors Exposure Food Food consumption Food contamination & poisoning Food safety Health risks Hormones Infants Information dissemination Mass spectrometry Mass spectroscopy Maternal and infant welfare Mathematical analysis Medical equipment Medicine Milk Neonates Phthalates Pollution monitoring Polymers Postpartum Public health Women |
| title | Lactational exposure to phthalate monoesters among breastfed infants in Italy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T13%3A39%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lactational%20exposure%20to%20phthalate%20monoesters%20among%20breastfed%20infants%20in%20Italy&rft.jtitle=European%20journal%20of%20public%20health&rft.au=Arletti,%20M&rft.date=2020-09-01&rft.volume=30&rft.issue=Supplement_5&rft.issn=1101-1262&rft.eissn=1464-360X&rft_id=info:doi/10.1093/eurpub/ckaa166.955&rft_dat=%3Cproquest_cross%3E2476160763%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2476160763&rft_id=info:pmid/&rft_oup_id=10.1093/eurpub/ckaa166.955&rfr_iscdi=true |