Fluoroalkyl‐Containing 1,2‐Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry

Synthesis of previously unavailable 1,2‐disubstituted cyclobutane building blocks bearing mono‐, di‐ and trifluoromethyl groups are disclosed. The key steps included deoxofluorination or TMAF‐mediated nucleophilic substitution in the appropriate bifunctional cyclobutanes; for the CF3‐substituted der...

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Veröffentlicht in:	European journal of organic chemistry 2021-01, Vol.2021 (1), p.87-95
Hauptverfasser:	Demchuk, Oleksandr P., Hryshchuk, Oleksandr V., Vashchenko, Bohdan V., Trofymchuk, Serhii A., Melnykov, Kostiantyn P., Skreminskiy, Artem, Volochnyuk, Dmitriy M., Grygorenko, Oleksandr O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Basicity Building blocks Carboxylic acids Chemical synthesis Cyclobutane Fluorine Lipophilicity Reagents
Online-Zugang:	Volltext
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