FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation

The human leukocyte antigen F-associated transcript 10 (FAT10) is a member of the small ubiquitin-like protein family that binds to its target proteins and subjects them to degradation by the ubiquitin–proteasome system (UPS). In the heart, FAT10 plays a cardioprotective role and affects predisposit...

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Veröffentlicht in:	Cell death & disease 2021-01, Vol.12 (1), p.25-25, Article 25
Hauptverfasser:	Liu, Xiao, Ge, Jin, Chen, Chen, Shen, Yang, Xie, Jinyan, Zhu, Xin, Liu, Menglu, Hu, Jinzhu, Chen, Leifeng, Guo, Linjuan, Zhou, Qiongqiong, Yan, Xia, Qiu, Yuming, Wan, Rong, Marian, Ali J., Hong, Kui
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/1 14/19 38/109 631/337/458 64/60 692/699/75/29 82/1 82/58 82/80 82/83 9/74 96/44 Action potential Antibodies Arrhythmia Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - pathology Biochemistry Biomedical and Life Sciences Cardiac arrhythmia Cardiomyocytes Cell Biology Cell Culture Degradation Depolarization Heart Histocompatibility antigen HLA Humans Immunofluorescence Immunology Ischemia Life Sciences Lysine Membrane proteins Mortality Myocardial ischemia Myocardial Ischemia - genetics Myocardial Ischemia - pathology Myocytes Nedd4 Ubiquitin Protein Ligases - metabolism Proteasomes Protein Processing, Post-Translational Proteins Sodium channels (voltage-gated) Transcription Ubiquitin Ubiquitin-protein ligase Ubiquitination Ubiquitins - metabolism Ventricle
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