Predictive ability of published population pharmacokinetic models of valproic acid in Thai manic patients

What is known and objective Population pharmacokinetic (PopPK) models of valproic acid (VPA) have been developed to aid individualized drug dosing, but most of these have been based on the treatment of epileptic patients and recent evidence shows that VPA clearance (CLVPA) in manic patients differs...

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Veröffentlicht in:	Journal of clinical pharmacy and therapeutics 2021-02, Vol.46 (1), p.198-207
Hauptverfasser:	Methaneethorn, Janthima, Leelakanok, Nattawut
Format:	Artikel
Sprache:	eng
Schlagworte:	Affective disorders Epilepsy non‐linear mixed‐effect modelling Pharmacokinetics population pharmacokinetics Predictions predictive performance Valproic acid
Online-Zugang:	Volltext
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