α-Synuclein aggregation and transmission in Parkinson’s disease: a link to mitochondria and lysosome

The presence of intraneuronal Lewy bodies (LBs) and Lewy neurites (LNs) in the substantia nigra (SN) composed of aggregated α-synuclein (α-syn) has been recognized as a hallmark of pathological changes in Parkinson’s disease (PD). Numerous studies have shown that aggregated α-syn is necessary for ne...

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Veröffentlicht in:	Science China. Life sciences 2020-12, Vol.63 (12), p.1850-1859
Hauptverfasser:	Wang, Rui, Sun, Hongyang, Ren, Haigang, Wang, Guanghui
Format:	Artikel
Sprache:	eng
Schlagworte:	Axons Biomedical and Life Sciences Disease transmission Lewy bodies Life Sciences Mitochondria Movement disorders Neurodegenerative diseases Neurotoxicity Parkinson's disease Pathogenicity Pathology Review Substantia nigra Synuclein
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