Molecular Mechanisms of Treatment Resistance in Glioblastoma

Glioblastoma is the most common malignant primary brain tumor in adults and is almost invariably fatal. Despite our growing understanding of the various mechanisms underlying treatment failure, the standard-of-care therapy has not changed over the last two decades, signifying a great unmet need. The...

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Veröffentlicht in:	International journal of molecular sciences 2020-12, Vol.22 (1), p.351
Hauptverfasser:	Ou, Alexander, Yung, W K Alfred, Majd, Nazanin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Blood-brain barrier Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Chemotherapy Clinical trials Cytotoxicity Drug Resistance, Neoplasm FDA approval Federal regulation Glioblastoma Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Heterogeneity Humans Hypoxia Immunotherapy Kinases Medical prognosis Microenvironments Molecular modelling Molecular Targeted Therapy Mutation Permeability Proteins Review Therapeutic applications Treatment resistance Tumor Microenvironment - drug effects Vascular endothelial growth factor
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