Nickel/Cobalt‐Catalyzed Reductive Hydrocyanation of Alkynes with Formamide as the Cyano Source, Dehydrant, Reductant, and Solvent

A Ni/Co co‐catalyzed reductive hydrocyanation of various alkynes was developed for the production of saturated nitriles. Hydrocyanic acid is generated in situ from safe and readily available formamide. Formamide played multiple roles as a cyano source, dehydrant, and reductant for the NiII pre‐catal...

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Veröffentlicht in:	Advanced synthesis & catalysis 2021-01, Vol.363 (1), p.283-288
Hauptverfasser:	Zhang, Jin, Luo, Cui‐Ping, Yang, Luo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Catalysts cyano source formamide hydrocyanation Hydrocyanic acid Nickel Nitriles Reducing agents reduction Solvents Substrates
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