PI3K-Akt-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis

Metabolic reprogramming plays a critical role in many diseases. A recent study revealed that aerobic glycolysis in lung tissue is closely related to pulmonary fibrosis, and also occurs during lipopolysaccharide (LPS)-induced sepsis. However, whether LPS induces aerobic glycolysis in lung fibroblasts...

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Veröffentlicht in:	Laboratory investigation 2020-06, Vol.100 (6), p.801-811
Hauptverfasser:	Hu, Xiaoting, Xu, Qiaoyi, Wan, Hanxi, Hu, Yue, Xing, Shunpeng, Yang, Hao, Gao, Yuan, He, Zhengyu
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13/1 13/44 13/51 6-Phosphofructo-2-kinase 631/80/304 64/60 692/699/1785 82 82/80 Activation AKT protein Animals Cell Line Chromones - pharmacology Collagen Collagen - metabolism Fibroblasts Fibroblasts - metabolism Fibrosis Fructose Glycolysis Glycolysis - drug effects Glycolysis - physiology Kinases Laboratory Medicine Lipopolysaccharides Lipopolysaccharides - adverse effects Lung - cytology Lung - metabolism Lung diseases Lungs Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Morpholines - pharmacology Pathology Phosphatidylinositol 3-Kinases - metabolism Phosphofructokinase-2 - metabolism Proto-Oncogene Proteins c-akt - metabolism Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - metabolism Rapamycin Sepsis Synthesis TOR protein TOR Serine-Threonine Kinases - metabolism
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