Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice

Thiopurines are widely used as antileukemia agents and immunosuppressants. Recent large-scale clinical studies revealed a strong association between the NUDT15 p.Arg139Cys ( NUDT15 R139C ) polymorphism and severe thiopurine-induced leukocytopenia. We established knock-in mice harboring p.Arg138Cys (...

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Veröffentlicht in:	Leukemia 2020-03, Vol.34 (3), p.882-894
Hauptverfasser:	Tatsumi, Goichi, Kawahara, Masahiro, Imai, Takayuki, Nishishita-Asai, Ai, Nishida, Atsushi, Inatomi, Osamu, Yokoyama, Akihiko, Kakuta, Yoichi, Kito, Katsuyuki, Andoh, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/100 13/106 13/31 13/44 13/51 14/63 38/109 38/22 38/77 6-Mercaptopurine 631/208/212/1728 64/60 692/699/1541/1990/283 82/58 Antileukemia agents Bone marrow Cancer Research Critical Care Medicine Damage tolerance Dosage Gene polymorphism Genotype & phenotype Hematology Hematopoietic stem cells Immunosuppressive agents Intensive Internal Medicine Leukemia Leukopenia Medicine Medicine & Public Health Oncology Polymorphism Precision medicine Progenitor cells Stem cell transplantation Stem cells Toxicity Transplantation
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