Encapsulation of Lactoferrin for Sustained Release Using Particles from Gas-Saturated Solutions
The particles from gas saturated solutions (PGSS) process were performed to encapsulate lactofer-rin, an iron-binding milk glycoprotein, using supercritical carbon dioxide (scCO2). A natural en-teric polymer, shellac, was used as a coating material of lactoferrin carried out by the PGSS pro-cess. Co...
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| Veröffentlicht in: | Processes 2021-01, Vol.9 (1), p.73 |
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| creator | Ono, Kento Sakai, Hiroki Tokunaga, Shinichi Sharmin, Tanjina Aida, Taku Michael Mishima, Kenji |
| description | The particles from gas saturated solutions (PGSS) process were performed to encapsulate lactofer-rin, an iron-binding milk glycoprotein, using supercritical carbon dioxide (scCO2). A natural en-teric polymer, shellac, was used as a coating material of lactoferrin carried out by the PGSS pro-cess. Conditions were optimized by applying different temperatures (20–50 °C) and pressures (8–10 MPa) and the particles were evaluated for particle shape and size, lactoferrin encapsulation ef-ficiency, Fourier transform infrared (FTIR) spectroscopy to confirm lactoferrin entrapment and in vitro dissolution studies at different pH values. Particles with an average diameter of 75.5 ± 7 μm were produced with encapsulation efficiency up to 71 ± 2%. Furthermore, particles that showed high stability in low pH (pH 1.2) and a sustained release over time (t2h = 75%) in higher pH (pH 7.4) suggested an effective encapsulation process for the protection of lactoferrin from gastric di-gestion. |
| doi_str_mv | 10.3390/pr9010073 |
| format | Article |
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A natural en-teric polymer, shellac, was used as a coating material of lactoferrin carried out by the PGSS pro-cess. Conditions were optimized by applying different temperatures (20–50 °C) and pressures (8–10 MPa) and the particles were evaluated for particle shape and size, lactoferrin encapsulation ef-ficiency, Fourier transform infrared (FTIR) spectroscopy to confirm lactoferrin entrapment and in vitro dissolution studies at different pH values. Particles with an average diameter of 75.5 ± 7 μm were produced with encapsulation efficiency up to 71 ± 2%. Furthermore, particles that showed high stability in low pH (pH 1.2) and a sustained release over time (t2h = 75%) in higher pH (pH 7.4) suggested an effective encapsulation process for the protection of lactoferrin from gastric di-gestion.</description><identifier>ISSN: 2227-9717</identifier><identifier>EISSN: 2227-9717</identifier><identifier>DOI: 10.3390/pr9010073</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Acids ; Carbon dioxide ; Controlled release ; Efficiency ; Encapsulation ; Entrapment ; Fourier transforms ; Glycoproteins ; Lactoferrin ; Milk ; Morphology ; Particle shape ; Particle size ; pH effects ; Polymers ; Severe acute respiratory syndrome coronavirus 2 ; Shellac ; Small intestine ; Sustained release ; Variance analysis</subject><ispartof>Processes, 2021-01, Vol.9 (1), p.73</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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A natural en-teric polymer, shellac, was used as a coating material of lactoferrin carried out by the PGSS pro-cess. Conditions were optimized by applying different temperatures (20–50 °C) and pressures (8–10 MPa) and the particles were evaluated for particle shape and size, lactoferrin encapsulation ef-ficiency, Fourier transform infrared (FTIR) spectroscopy to confirm lactoferrin entrapment and in vitro dissolution studies at different pH values. Particles with an average diameter of 75.5 ± 7 μm were produced with encapsulation efficiency up to 71 ± 2%. Furthermore, particles that showed high stability in low pH (pH 1.2) and a sustained release over time (t2h = 75%) in higher pH (pH 7.4) suggested an effective encapsulation process for the protection of lactoferrin from gastric di-gestion.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/pr9010073</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Carbon dioxide Controlled release Efficiency Encapsulation Entrapment Fourier transforms Glycoproteins Lactoferrin Milk Morphology Particle shape Particle size pH effects Polymers Severe acute respiratory syndrome coronavirus 2 Shellac Small intestine Sustained release Variance analysis |
| title | Encapsulation of Lactoferrin for Sustained Release Using Particles from Gas-Saturated Solutions |
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