Generation and infusion of multi-antigen-specific T cells to prevent complications early after T-cell depleted allogeneic stem cell transplantation—a phase I/II study

Prophylactic infusion of selected donor T cells can be an effective method to restore specific immunity after T-cell-depleted allogeneic stem cell transplantation (TCD-alloSCT). In this phase I/II study, we aimed to reduce the risk of viral complications and disease relapses by administrating donor-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2020-03, Vol.34 (3), p.831-844
Hauptverfasser:	Roex, Marthe C. J., van Balen, Peter, Germeroth, Lothar, Hageman, Lois, van Egmond, Esther, Veld, Sabrina A. J., Hoogstraten, Conny, van Liempt, Ellis, Zwaginga, Jaap J., de Wreede, Liesbeth C., Meij, Pauline, Vossen, Ann C. T. M., Danhof, Sophia, Einsele, Hermann, Schaafsma, M. Ron, Veelken, Hendrik, Halkes, Constantijn J. M., Jedema, Inge, Falkenburg, J. H. Frederik
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 631/250/1904 631/250/251 631/67/1990 692/308/2779/109/1940 692/308/575 Adenoviridae Infections - prevention & control Adult Aged Antigen (tumor-associated) Antigens Antigens, Neoplasm - immunology Cancer Research CD8-Positive T-Lymphocytes - cytology Complications Critical Care Medicine Cytomegalovirus Cytomegalovirus Infections - prevention & control Depletion Epstein-Barr virus Epstein-Barr Virus Infections - prevention & control Expansion Feasibility Studies Female Graft-versus-host reaction Health aspects Hematologic Neoplasms - complications Hematologic Neoplasms - immunology Hematologic Neoplasms - therapy Hematology Histocompatibility antigen HLA Humans Immunotherapy Intensive Internal Medicine Lymphocytes Lymphocytes T Major histocompatibility complex Male Medical treatment Medicine Medicine & Public Health Middle Aged Minor histocompatibility antigens Minor Histocompatibility Antigens - immunology Oncology Patient Safety Prevention Stem Cell Transplantation Stem cells T cells T-Lymphocytes - immunology Transplantation Transplantation, Homologous Viral diseases Virus diseases Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!