Creating CRISPR-responsive smart materials for diagnostics and programmable cargo release

Materials that sense and respond to biological signals in their environment have a broad range of potential applications in drug delivery, medical devices and diagnostics. Nucleic acids are important biological cues that encode information about organismal identity and clinically relevant phenotypes...

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Veröffentlicht in:	Nature protocols 2020-09, Vol.15 (9), p.3030-3063
Hauptverfasser:	Gayet, Raphael V., de Puig, Helena, English, Max A., Soenksen, Luis R., Nguyen, Peter Q., Mao, Angelo S., Angenent-Mari, Nicolaas M., Collins, James J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/2521 631/337/4041 631/92/152 639/301/54/992 639/301/923/1027 Acrylic Resins - chemistry Actuation Actuators Analytical Chemistry Bacterial Proteins - metabolism Base Sequence Biodegradation Biological Techniques Biomedical and Life Sciences Cells (biology) Clustered Regularly Interspaced Short Palindromic Repeats - genetics Computational Biology/Bioinformatics Controlled release CRISPR CRISPR-Associated Proteins - metabolism Deoxyribonucleic acid Design Diagnostic software Diagnostic systems Diagnostic Techniques and Procedures DNA DNA - chemistry DNA - genetics Drug delivery Drug delivery systems Drug Delivery Systems - methods Drug development Drug Liberation Drug resistance Endodeoxyribonucleases - metabolism Enzymes gRNA Humans Hydrogels Information processing K562 Cells Life Sciences Medical equipment Medical testing products Microarrays Microfluidics Nanoparticles Nuclease Nucleic acids Nucleotide sequence Organic Chemistry Phenotypes Polyacrylamide Polyethylene glycol Polyethylene Glycols - chemistry Protocol RNA, Guide, CRISPR-Cas Systems - genetics Smart materials Smart Materials - chemistry Synthesis Testing
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