Satb2 is required for the regionalization of retrosplenial cortex
The retrosplenial cortex (Rsp) is a transitional cortex located between the neocortex and archicortex, but the molecular mechanism specifying Rsp from the archicortex remains elusive. We here report that the transcription factor Satb2 is required for specifying Rsp identity during its morphogenesis....
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| Veröffentlicht in: | Cell death and differentiation 2020-05, Vol.27 (5), p.1604-1617 |
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| creator | Zhang, Lei Song, Ning-Ning Zhang, Qiong Mei, Wan-Ying He, Chun-Hui Ma, Pengcheng Huang, Ying Chen, Jia-Yin Mao, Bingyu Lang, Bing Ding, Yu-Qiang |
| description | The retrosplenial cortex (Rsp) is a transitional cortex located between the neocortex and archicortex, but the molecular mechanism specifying Rsp from the archicortex remains elusive. We here report that the transcription factor Satb2 is required for specifying Rsp identity during its morphogenesis. In Satb2 CKO mice, the boundary between the Rsp and archicortex [i.e., subiculum (SubC)] disappears as early as E17.5, and Rsp efferent projection is aberrant. Rsp-specific genes are lost, whereas SubC-specific genes are ectopically expressed in Rsp of Satb2 CKO mice. Furthermore, cell-autonomous role of Satb2 in maintaining Rsp neuron identity is revealed by inactivation of Satb2 in Rsp neurons. Finally, Satb2 represses the transcription of Nr4a2. The misexpression of Nr4a2 together with Ctip2 induces expression of SubC-specific genes in wild-type Rsp, and simultaneous knockdown of these two genes in Rsp Satb2-mutant cells prevents their fate transition to SubC identity. Thus, Satb2 serves as a determinant gene in the Rsp regionalization by repressing Nr4a2 and Ctip2 during cortical development. |
| doi_str_mv | 10.1038/s41418-019-0443-1 |
| format | Article |
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We here report that the transcription factor Satb2 is required for specifying Rsp identity during its morphogenesis. In Satb2 CKO mice, the boundary between the Rsp and archicortex [i.e., subiculum (SubC)] disappears as early as E17.5, and Rsp efferent projection is aberrant. Rsp-specific genes are lost, whereas SubC-specific genes are ectopically expressed in Rsp of Satb2 CKO mice. Furthermore, cell-autonomous role of Satb2 in maintaining Rsp neuron identity is revealed by inactivation of Satb2 in Rsp neurons. Finally, Satb2 represses the transcription of Nr4a2. The misexpression of Nr4a2 together with Ctip2 induces expression of SubC-specific genes in wild-type Rsp, and simultaneous knockdown of these two genes in Rsp Satb2-mutant cells prevents their fate transition to SubC identity. Thus, Satb2 serves as a determinant gene in the Rsp regionalization by repressing Nr4a2 and Ctip2 during cortical development.</description><identifier>ISSN: 1350-9047</identifier><identifier>ISSN: 1476-5403</identifier><identifier>EISSN: 1476-5403</identifier><identifier>DOI: 10.1038/s41418-019-0443-1</identifier><identifier>PMID: 31666685</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 13/89 ; 42/109 ; 631/208/135 ; 631/378/2611 ; 64/60 ; Animal memory ; Animals ; Apoptosis ; Archicortex ; Biochemistry ; Biochemistry & Molecular Biology ; Biomedical and Life Sciences ; Cell Adhesion Molecules, Neuronal - metabolism ; Cell Biology ; Cell Cycle Analysis ; Cell Lineage ; Cerebral cortex ; Gene Expression Regulation ; Gyrus Cinguli - metabolism ; HEK293 Cells ; Humans ; Life Sciences ; Life Sciences & Biomedicine ; Mice, Knockout ; Morphogenesis ; Neocortex ; Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism ; Repressor Proteins - metabolism ; Science & Technology ; Stem Cells ; Subiculum ; Tumor Suppressor Proteins - metabolism</subject><ispartof>Cell death and differentiation, 2020-05, Vol.27 (5), p.1604-1617</ispartof><rights>The Author(s) 2019</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2019. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>15</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000528065200012</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c498t-7e896293c263ee5993f451542343521f86cad2677baeadd783ec004a851765273</citedby><cites>FETCH-LOGICAL-c498t-7e896293c263ee5993f451542343521f86cad2677baeadd783ec004a851765273</cites><orcidid>0000-0001-7242-5292 ; 0000-0002-7993-3158 ; 0000-0003-1202-4635</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206047/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206047/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31666685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Song, Ning-Ning</creatorcontrib><creatorcontrib>Zhang, Qiong</creatorcontrib><creatorcontrib>Mei, Wan-Ying</creatorcontrib><creatorcontrib>He, Chun-Hui</creatorcontrib><creatorcontrib>Ma, Pengcheng</creatorcontrib><creatorcontrib>Huang, Ying</creatorcontrib><creatorcontrib>Chen, Jia-Yin</creatorcontrib><creatorcontrib>Mao, Bingyu</creatorcontrib><creatorcontrib>Lang, Bing</creatorcontrib><creatorcontrib>Ding, Yu-Qiang</creatorcontrib><title>Satb2 is required for the regionalization of retrosplenial cortex</title><title>Cell death and differentiation</title><addtitle>Cell Death Differ</addtitle><addtitle>CELL DEATH DIFFER</addtitle><addtitle>Cell Death Differ</addtitle><description>The retrosplenial cortex (Rsp) is a transitional cortex located between the neocortex and archicortex, but the molecular mechanism specifying Rsp from the archicortex remains elusive. We here report that the transcription factor Satb2 is required for specifying Rsp identity during its morphogenesis. In Satb2 CKO mice, the boundary between the Rsp and archicortex [i.e., subiculum (SubC)] disappears as early as E17.5, and Rsp efferent projection is aberrant. Rsp-specific genes are lost, whereas SubC-specific genes are ectopically expressed in Rsp of Satb2 CKO mice. Furthermore, cell-autonomous role of Satb2 in maintaining Rsp neuron identity is revealed by inactivation of Satb2 in Rsp neurons. Finally, Satb2 represses the transcription of Nr4a2. The misexpression of Nr4a2 together with Ctip2 induces expression of SubC-specific genes in wild-type Rsp, and simultaneous knockdown of these two genes in Rsp Satb2-mutant cells prevents their fate transition to SubC identity. Thus, Satb2 serves as a determinant gene in the Rsp regionalization by repressing Nr4a2 and Ctip2 during cortical development.</description><subject>13/51</subject><subject>13/89</subject><subject>42/109</subject><subject>631/208/135</subject><subject>631/378/2611</subject><subject>64/60</subject><subject>Animal memory</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Archicortex</subject><subject>Biochemistry</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Adhesion Molecules, Neuronal - metabolism</subject><subject>Cell Biology</subject><subject>Cell Cycle Analysis</subject><subject>Cell Lineage</subject><subject>Cerebral cortex</subject><subject>Gene Expression Regulation</subject><subject>Gyrus Cinguli - metabolism</subject><subject>HEK293 Cells</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Life Sciences & Biomedicine</subject><subject>Mice, Knockout</subject><subject>Morphogenesis</subject><subject>Neocortex</subject><subject>Nuclear Receptor Subfamily 4, Group A, Member 2 - 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metabolism</topic><topic>Cell Biology</topic><topic>Cell Cycle Analysis</topic><topic>Cell Lineage</topic><topic>Cerebral cortex</topic><topic>Gene Expression Regulation</topic><topic>Gyrus Cinguli - metabolism</topic><topic>HEK293 Cells</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Life Sciences & Biomedicine</topic><topic>Mice, Knockout</topic><topic>Morphogenesis</topic><topic>Neocortex</topic><topic>Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism</topic><topic>Repressor Proteins - metabolism</topic><topic>Science & Technology</topic><topic>Stem Cells</topic><topic>Subiculum</topic><topic>Tumor Suppressor Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Song, Ning-Ning</creatorcontrib><creatorcontrib>Zhang, Qiong</creatorcontrib><creatorcontrib>Mei, Wan-Ying</creatorcontrib><creatorcontrib>He, Chun-Hui</creatorcontrib><creatorcontrib>Ma, Pengcheng</creatorcontrib><creatorcontrib>Huang, Ying</creatorcontrib><creatorcontrib>Chen, Jia-Yin</creatorcontrib><creatorcontrib>Mao, Bingyu</creatorcontrib><creatorcontrib>Lang, Bing</creatorcontrib><creatorcontrib>Ding, Yu-Qiang</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Web of Science - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell death and differentiation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Lei</au><au>Song, Ning-Ning</au><au>Zhang, Qiong</au><au>Mei, Wan-Ying</au><au>He, Chun-Hui</au><au>Ma, Pengcheng</au><au>Huang, Ying</au><au>Chen, Jia-Yin</au><au>Mao, Bingyu</au><au>Lang, Bing</au><au>Ding, Yu-Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Satb2 is required for the regionalization of retrosplenial cortex</atitle><jtitle>Cell death and differentiation</jtitle><stitle>Cell Death Differ</stitle><stitle>CELL DEATH DIFFER</stitle><addtitle>Cell Death Differ</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>27</volume><issue>5</issue><spage>1604</spage><epage>1617</epage><pages>1604-1617</pages><issn>1350-9047</issn><issn>1476-5403</issn><eissn>1476-5403</eissn><abstract>The retrosplenial cortex (Rsp) is a transitional cortex located between the neocortex and archicortex, but the molecular mechanism specifying Rsp from the archicortex remains elusive. We here report that the transcription factor Satb2 is required for specifying Rsp identity during its morphogenesis. In Satb2 CKO mice, the boundary between the Rsp and archicortex [i.e., subiculum (SubC)] disappears as early as E17.5, and Rsp efferent projection is aberrant. Rsp-specific genes are lost, whereas SubC-specific genes are ectopically expressed in Rsp of Satb2 CKO mice. Furthermore, cell-autonomous role of Satb2 in maintaining Rsp neuron identity is revealed by inactivation of Satb2 in Rsp neurons. Finally, Satb2 represses the transcription of Nr4a2. The misexpression of Nr4a2 together with Ctip2 induces expression of SubC-specific genes in wild-type Rsp, and simultaneous knockdown of these two genes in Rsp Satb2-mutant cells prevents their fate transition to SubC identity. Thus, Satb2 serves as a determinant gene in the Rsp regionalization by repressing Nr4a2 and Ctip2 during cortical development.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31666685</pmid><doi>10.1038/s41418-019-0443-1</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-7242-5292</orcidid><orcidid>https://orcid.org/0000-0002-7993-3158</orcidid><orcidid>https://orcid.org/0000-0003-1202-4635</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 13/51 13/89 42/109 631/208/135 631/378/2611 64/60 Animal memory Animals Apoptosis Archicortex Biochemistry Biochemistry & Molecular Biology Biomedical and Life Sciences Cell Adhesion Molecules, Neuronal - metabolism Cell Biology Cell Cycle Analysis Cell Lineage Cerebral cortex Gene Expression Regulation Gyrus Cinguli - metabolism HEK293 Cells Humans Life Sciences Life Sciences & Biomedicine Mice, Knockout Morphogenesis Neocortex Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism Repressor Proteins - metabolism Science & Technology Stem Cells Subiculum Tumor Suppressor Proteins - metabolism |
| title | Satb2 is required for the regionalization of retrosplenial cortex |
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