Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease

Lysine acetylation is a conserved, reversible, post-translational protein modification regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known as histone deacetylases (HDACs)) that is involved in many cellular signalling pathways and diseases. Studies in animal model...

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Veröffentlicht in:	Nature reviews cardiology 2020-02, Vol.17 (2), p.96-115
Hauptverfasser:	Li, Peng, Ge, Junbo, Li, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4019/592/75 692/700/565/1436/152 Acetylation Angiogenesis Animals Atherosclerosis Blood pressure Cardiac arrhythmia Cardiac Imaging Cardiac Surgery Cardiology Cardiovascular Agents - therapeutic use Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - diagnosis Cardiovascular Diseases - drug therapy Cardiovascular Diseases - enzymology Cardiovascular Diseases - physiopathology Cardiovascular research Cardiovascular System - drug effects Cardiovascular System - enzymology Cardiovascular System - physiopathology Care and treatment Development and progression Enzyme inhibitors Enzymes Gene expression Health aspects Heart failure Histone Deacetylase Inhibitors - therapeutic use Histone Deacetylases - metabolism Humans Hypertension Lymphocytes Lymphoma Lysine Lysine Acetyltransferases - antagonists & inhibitors Lysine Acetyltransferases - metabolism Medicine Medicine & Public Health Molecular Targeted Therapy Physiological aspects Post-translational modification Protein Processing, Post-Translational - drug effects Proteins Regulatory approval Review Article RNA polymerase Roles Signal Transduction Transferases
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