Adoptive transfer of CD 3 + T cells and CD 4 + CD 44 high memory T cells induces autoimmune pancreatitis in MRL /MpJ mice

The immunopathogenesis of autoimmune pancreatitis ( AIP ) is poorly understood. Here, we have used MRL /MpJ mice, a model of spontaneous AIP , to address the role of cellular autoimmune processes in the initiation and progression of the disease. Therefore, different T cell subpopulations were adopti...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2018-04, Vol.22 (4), p.2404-2412
Hauptverfasser:	Ehlers, Luise, Rohde, Sarah, Ibrahim, Saleh, Jaster, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Age Animals Autoimmunity CD3 antigen CD4 antigen CD8 antigen Cell culture Cytotoxicity Disease Experiments Immunological memory Immunopathogenesis Immunoregulation Lymphocytes Lymphocytes T Memory cells Pancreas Pancreatic cancer Pancreatitis Pathogenesis Splenocytes
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