Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients

Aim A diverse combination of etiologies such as vascular and inflammatory factors and social and physical inactivity may take place in the etiology of cognitive dysfunction (CD). Diabetes mellitus (DM) may contribute to CD over insulin resistance, inflammation, and vascular risk factors. However, me...

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Veröffentlicht in:International journal of diabetes in developing countries 2020-10, Vol.40 (4), p.525-531
Hauptverfasser: Savas, Sumru, Tayfur, Eda, Sarac, Fulden, Akbaş, Sibel, Acarer, Ahmet, Gündüz, Cumhur, Akkuş, Dilek Evyapan, Akcicek, Fehmi
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container_end_page 531
container_issue 4
container_start_page 525
container_title International journal of diabetes in developing countries
container_volume 40
creator Savas, Sumru
Tayfur, Eda
Sarac, Fulden
Akbaş, Sibel
Acarer, Ahmet
Gündüz, Cumhur
Akkuş, Dilek Evyapan
Akcicek, Fehmi
description Aim A diverse combination of etiologies such as vascular and inflammatory factors and social and physical inactivity may take place in the etiology of cognitive dysfunction (CD). Diabetes mellitus (DM) may contribute to CD over insulin resistance, inflammation, and vascular risk factors. However, mechanisms included in the process are not very clear. We aimed to investigate serum levels of selected biomarkers as a proliferation-inducing ligand (APRIL), FGF-21, P-selectin, soluble vascular cell, and intercellular adhesion molecules-1 (sVCAM-1 and sICAM-1) in elderly patients with DM in relation to cognitive function. Methods A group of 80 elderly type 2 diabetic patients from the outpatient clinic, consisting of 40 patients with CD (mini-mental state examination (MMSE) score
doi_str_mv 10.1007/s13410-020-00832-5
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Diabetes mellitus (DM) may contribute to CD over insulin resistance, inflammation, and vascular risk factors. However, mechanisms included in the process are not very clear. We aimed to investigate serum levels of selected biomarkers as a proliferation-inducing ligand (APRIL), FGF-21, P-selectin, soluble vascular cell, and intercellular adhesion molecules-1 (sVCAM-1 and sICAM-1) in elderly patients with DM in relation to cognitive function. Methods A group of 80 elderly type 2 diabetic patients from the outpatient clinic, consisting of 40 patients with CD (mini-mental state examination (MMSE) score &lt; 24) and 40 individuals without CD were enrolled in the study. Anthropometric, sociodemographic, and functional-glycemic evaluations were determined. Biomarker levels were determined by enzyme-linked immunosorbent assay. Results Median sICAM-1 and FGF-21 levels were higher, and P-selectin level, activities of daily living (ADL), instrumental ADL, MNA, and MMSE scores were lower in the CD group ( p  = 0.002, p  = 0.010, p  = 0.001, p  = 0.001, p  &lt; 0.001, p  = 0.005, p  &lt; 0.001, respectively). There was no significant difference between the groups regarding age, gender, living status, education, cigarette and alcohol consumption, antidiabetic therapy as well as comorbidities such as hypertension and other diseases, depression, body composition, sVCAM-1, APRIL levels, and related biochemical values. Conclusion Median sICAM-1 and FGF-21 levels were higher and P-selectin level was lower in older diabetic patients with CD than in patients with normal cognitive status. Understanding the mechanisms may lead to the prevention or delay of CD in those patients.</description><identifier>ISSN: 0973-3930</identifier><identifier>EISSN: 1998-3832</identifier><identifier>DOI: 10.1007/s13410-020-00832-5</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Activities of daily living ; Antidiabetics ; APRIL protein ; Biomarkers ; Body composition ; Cell adhesion ; Cell adhesion molecules ; Cognitive ability ; Diabetes ; Diabetes mellitus ; Enzyme-linked immunosorbent assay ; Etiology ; Family Medicine ; Fibroblast growth factors ; General Practice ; Health Administration ; Inflammation ; Insulin ; Medicine ; Medicine &amp; Public Health ; Original Article ; P-selectin ; Risk factors ; Serum levels</subject><ispartof>International journal of diabetes in developing countries, 2020-10, Vol.40 (4), p.525-531</ispartof><rights>Research Society for Study of Diabetes in India 2020</rights><rights>Research Society for Study of Diabetes in India 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-272528ada0b212200411daf4d07234db104f793df01fc6c4d31cbe8109ee755d3</citedby><cites>FETCH-LOGICAL-c319t-272528ada0b212200411daf4d07234db104f793df01fc6c4d31cbe8109ee755d3</cites><orcidid>0000-0003-4836-3786</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13410-020-00832-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13410-020-00832-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Savas, Sumru</creatorcontrib><creatorcontrib>Tayfur, Eda</creatorcontrib><creatorcontrib>Sarac, Fulden</creatorcontrib><creatorcontrib>Akbaş, Sibel</creatorcontrib><creatorcontrib>Acarer, Ahmet</creatorcontrib><creatorcontrib>Gündüz, Cumhur</creatorcontrib><creatorcontrib>Akkuş, Dilek Evyapan</creatorcontrib><creatorcontrib>Akcicek, Fehmi</creatorcontrib><title>Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients</title><title>International journal of diabetes in developing countries</title><addtitle>Int J Diabetes Dev Ctries</addtitle><description>Aim A diverse combination of etiologies such as vascular and inflammatory factors and social and physical inactivity may take place in the etiology of cognitive dysfunction (CD). Diabetes mellitus (DM) may contribute to CD over insulin resistance, inflammation, and vascular risk factors. However, mechanisms included in the process are not very clear. We aimed to investigate serum levels of selected biomarkers as a proliferation-inducing ligand (APRIL), FGF-21, P-selectin, soluble vascular cell, and intercellular adhesion molecules-1 (sVCAM-1 and sICAM-1) in elderly patients with DM in relation to cognitive function. Methods A group of 80 elderly type 2 diabetic patients from the outpatient clinic, consisting of 40 patients with CD (mini-mental state examination (MMSE) score &lt; 24) and 40 individuals without CD were enrolled in the study. Anthropometric, sociodemographic, and functional-glycemic evaluations were determined. Biomarker levels were determined by enzyme-linked immunosorbent assay. Results Median sICAM-1 and FGF-21 levels were higher, and P-selectin level, activities of daily living (ADL), instrumental ADL, MNA, and MMSE scores were lower in the CD group ( p  = 0.002, p  = 0.010, p  = 0.001, p  = 0.001, p  &lt; 0.001, p  = 0.005, p  &lt; 0.001, respectively). There was no significant difference between the groups regarding age, gender, living status, education, cigarette and alcohol consumption, antidiabetic therapy as well as comorbidities such as hypertension and other diseases, depression, body composition, sVCAM-1, APRIL levels, and related biochemical values. Conclusion Median sICAM-1 and FGF-21 levels were higher and P-selectin level was lower in older diabetic patients with CD than in patients with normal cognitive status. Understanding the mechanisms may lead to the prevention or delay of CD in those patients.</description><subject>Activities of daily living</subject><subject>Antidiabetics</subject><subject>APRIL protein</subject><subject>Biomarkers</subject><subject>Body composition</subject><subject>Cell adhesion</subject><subject>Cell adhesion molecules</subject><subject>Cognitive ability</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Etiology</subject><subject>Family Medicine</subject><subject>Fibroblast growth factors</subject><subject>General Practice</subject><subject>Health Administration</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Original Article</subject><subject>P-selectin</subject><subject>Risk factors</subject><subject>Serum levels</subject><issn>0973-3930</issn><issn>1998-3832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEUhYMoWKt_wFXAdfQmmWlmlqXYBxQU0XXIJHfqlGmmJjNC_71pK7hzcbkPzncuHELuOTxyAPUUucw4MBCpoJCC5RdkxMuyYDJtl2QEpZJMlhKuyU2MW4A8FxM5Iu1y2BlPp69vqzU13tH5Ys4EP43GfWJsOk93XYt2aDHSxtOAremP176jttv4pm--kdaDt6drUmDrMLQH6hpTYd9Yuk8A-j7ekqvatBHvfvuYfMyf32dLtn5ZrGbTNbOSlz0TSuSiMM5AJbgQABnnztSZAyVk5ioOWa1K6WrgtZ3YzEluKyw4lIgqz50ck4ez7z50XwPGXm-7Ifj0UotMSVWICS-SSpxVNnQxBqz1PjQ7Ew6agz6mqs-p6pSqPqWq8wTJMxST2G8w_Fn_Q_0A_nJ5bw</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Savas, Sumru</creator><creator>Tayfur, Eda</creator><creator>Sarac, Fulden</creator><creator>Akbaş, Sibel</creator><creator>Acarer, Ahmet</creator><creator>Gündüz, Cumhur</creator><creator>Akkuş, Dilek Evyapan</creator><creator>Akcicek, Fehmi</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0003-4836-3786</orcidid></search><sort><creationdate>20201001</creationdate><title>Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients</title><author>Savas, Sumru ; Tayfur, Eda ; Sarac, Fulden ; Akbaş, Sibel ; Acarer, Ahmet ; Gündüz, Cumhur ; Akkuş, Dilek Evyapan ; Akcicek, Fehmi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-272528ada0b212200411daf4d07234db104f793df01fc6c4d31cbe8109ee755d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Activities of daily living</topic><topic>Antidiabetics</topic><topic>APRIL protein</topic><topic>Biomarkers</topic><topic>Body composition</topic><topic>Cell adhesion</topic><topic>Cell adhesion molecules</topic><topic>Cognitive ability</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Etiology</topic><topic>Family Medicine</topic><topic>Fibroblast growth factors</topic><topic>General Practice</topic><topic>Health Administration</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Original Article</topic><topic>P-selectin</topic><topic>Risk factors</topic><topic>Serum levels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savas, Sumru</creatorcontrib><creatorcontrib>Tayfur, Eda</creatorcontrib><creatorcontrib>Sarac, Fulden</creatorcontrib><creatorcontrib>Akbaş, Sibel</creatorcontrib><creatorcontrib>Acarer, Ahmet</creatorcontrib><creatorcontrib>Gündüz, Cumhur</creatorcontrib><creatorcontrib>Akkuş, Dilek Evyapan</creatorcontrib><creatorcontrib>Akcicek, Fehmi</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><jtitle>International journal of diabetes in developing countries</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savas, Sumru</au><au>Tayfur, Eda</au><au>Sarac, Fulden</au><au>Akbaş, Sibel</au><au>Acarer, Ahmet</au><au>Gündüz, Cumhur</au><au>Akkuş, Dilek Evyapan</au><au>Akcicek, Fehmi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients</atitle><jtitle>International journal of diabetes in developing countries</jtitle><stitle>Int J Diabetes Dev Ctries</stitle><date>2020-10-01</date><risdate>2020</risdate><volume>40</volume><issue>4</issue><spage>525</spage><epage>531</epage><pages>525-531</pages><issn>0973-3930</issn><eissn>1998-3832</eissn><abstract>Aim A diverse combination of etiologies such as vascular and inflammatory factors and social and physical inactivity may take place in the etiology of cognitive dysfunction (CD). Diabetes mellitus (DM) may contribute to CD over insulin resistance, inflammation, and vascular risk factors. However, mechanisms included in the process are not very clear. We aimed to investigate serum levels of selected biomarkers as a proliferation-inducing ligand (APRIL), FGF-21, P-selectin, soluble vascular cell, and intercellular adhesion molecules-1 (sVCAM-1 and sICAM-1) in elderly patients with DM in relation to cognitive function. Methods A group of 80 elderly type 2 diabetic patients from the outpatient clinic, consisting of 40 patients with CD (mini-mental state examination (MMSE) score &lt; 24) and 40 individuals without CD were enrolled in the study. Anthropometric, sociodemographic, and functional-glycemic evaluations were determined. Biomarker levels were determined by enzyme-linked immunosorbent assay. Results Median sICAM-1 and FGF-21 levels were higher, and P-selectin level, activities of daily living (ADL), instrumental ADL, MNA, and MMSE scores were lower in the CD group ( p  = 0.002, p  = 0.010, p  = 0.001, p  = 0.001, p  &lt; 0.001, p  = 0.005, p  &lt; 0.001, respectively). There was no significant difference between the groups regarding age, gender, living status, education, cigarette and alcohol consumption, antidiabetic therapy as well as comorbidities such as hypertension and other diseases, depression, body composition, sVCAM-1, APRIL levels, and related biochemical values. Conclusion Median sICAM-1 and FGF-21 levels were higher and P-selectin level was lower in older diabetic patients with CD than in patients with normal cognitive status. Understanding the mechanisms may lead to the prevention or delay of CD in those patients.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s13410-020-00832-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4836-3786</orcidid></addata></record>
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subjects Activities of daily living
Antidiabetics
APRIL protein
Biomarkers
Body composition
Cell adhesion
Cell adhesion molecules
Cognitive ability
Diabetes
Diabetes mellitus
Enzyme-linked immunosorbent assay
Etiology
Family Medicine
Fibroblast growth factors
General Practice
Health Administration
Inflammation
Insulin
Medicine
Medicine & Public Health
Original Article
P-selectin
Risk factors
Serum levels
title Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients
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