Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients
Aim A diverse combination of etiologies such as vascular and inflammatory factors and social and physical inactivity may take place in the etiology of cognitive dysfunction (CD). Diabetes mellitus (DM) may contribute to CD over insulin resistance, inflammation, and vascular risk factors. However, me...
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Veröffentlicht in: | International journal of diabetes in developing countries 2020-10, Vol.40 (4), p.525-531 |
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container_title | International journal of diabetes in developing countries |
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creator | Savas, Sumru Tayfur, Eda Sarac, Fulden Akbaş, Sibel Acarer, Ahmet Gündüz, Cumhur Akkuş, Dilek Evyapan Akcicek, Fehmi |
description | Aim
A diverse combination of etiologies such as vascular and inflammatory factors and social and physical inactivity may take place in the etiology of cognitive dysfunction (CD). Diabetes mellitus (DM) may contribute to CD over insulin resistance, inflammation, and vascular risk factors. However, mechanisms included in the process are not very clear. We aimed to investigate serum levels of selected biomarkers as a proliferation-inducing ligand (APRIL), FGF-21, P-selectin, soluble vascular cell, and intercellular adhesion molecules-1 (sVCAM-1 and sICAM-1) in elderly patients with DM in relation to cognitive function.
Methods
A group of 80 elderly type 2 diabetic patients from the outpatient clinic, consisting of 40 patients with CD (mini-mental state examination (MMSE) score |
doi_str_mv | 10.1007/s13410-020-00832-5 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2473782618</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2473782618</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-272528ada0b212200411daf4d07234db104f793df01fc6c4d31cbe8109ee755d3</originalsourceid><addsrcrecordid>eNp9kEtLAzEUhYMoWKt_wFXAdfQmmWlmlqXYBxQU0XXIJHfqlGmmJjNC_71pK7hzcbkPzncuHELuOTxyAPUUucw4MBCpoJCC5RdkxMuyYDJtl2QEpZJMlhKuyU2MW4A8FxM5Iu1y2BlPp69vqzU13tH5Ys4EP43GfWJsOk93XYt2aDHSxtOAremP176jttv4pm--kdaDt6drUmDrMLQH6hpTYd9Yuk8A-j7ekqvatBHvfvuYfMyf32dLtn5ZrGbTNbOSlz0TSuSiMM5AJbgQABnnztSZAyVk5ioOWa1K6WrgtZ3YzEluKyw4lIgqz50ck4ez7z50XwPGXm-7Ifj0UotMSVWICS-SSpxVNnQxBqz1PjQ7Ew6agz6mqs-p6pSqPqWq8wTJMxST2G8w_Fn_Q_0A_nJ5bw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473782618</pqid></control><display><type>article</type><title>Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients</title><source>SpringerLink Journals - AutoHoldings</source><creator>Savas, Sumru ; Tayfur, Eda ; Sarac, Fulden ; Akbaş, Sibel ; Acarer, Ahmet ; Gündüz, Cumhur ; Akkuş, Dilek Evyapan ; Akcicek, Fehmi</creator><creatorcontrib>Savas, Sumru ; Tayfur, Eda ; Sarac, Fulden ; Akbaş, Sibel ; Acarer, Ahmet ; Gündüz, Cumhur ; Akkuş, Dilek Evyapan ; Akcicek, Fehmi</creatorcontrib><description>Aim
A diverse combination of etiologies such as vascular and inflammatory factors and social and physical inactivity may take place in the etiology of cognitive dysfunction (CD). Diabetes mellitus (DM) may contribute to CD over insulin resistance, inflammation, and vascular risk factors. However, mechanisms included in the process are not very clear. We aimed to investigate serum levels of selected biomarkers as a proliferation-inducing ligand (APRIL), FGF-21, P-selectin, soluble vascular cell, and intercellular adhesion molecules-1 (sVCAM-1 and sICAM-1) in elderly patients with DM in relation to cognitive function.
Methods
A group of 80 elderly type 2 diabetic patients from the outpatient clinic, consisting of 40 patients with CD (mini-mental state examination (MMSE) score < 24) and 40 individuals without CD were enrolled in the study. Anthropometric, sociodemographic, and functional-glycemic evaluations were determined. Biomarker levels were determined by enzyme-linked immunosorbent assay.
Results
Median sICAM-1 and FGF-21 levels were higher, and P-selectin level, activities of daily living (ADL), instrumental ADL, MNA, and MMSE scores were lower in the CD group (
p
= 0.002,
p
= 0.010,
p
= 0.001,
p
= 0.001,
p
< 0.001,
p
= 0.005,
p
< 0.001, respectively). There was no significant difference between the groups regarding age, gender, living status, education, cigarette and alcohol consumption, antidiabetic therapy as well as comorbidities such as hypertension and other diseases, depression, body composition, sVCAM-1, APRIL levels, and related biochemical values.
Conclusion
Median sICAM-1 and FGF-21 levels were higher and P-selectin level was lower in older diabetic patients with CD than in patients with normal cognitive status. Understanding the mechanisms may lead to the prevention or delay of CD in those patients.</description><identifier>ISSN: 0973-3930</identifier><identifier>EISSN: 1998-3832</identifier><identifier>DOI: 10.1007/s13410-020-00832-5</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Activities of daily living ; Antidiabetics ; APRIL protein ; Biomarkers ; Body composition ; Cell adhesion ; Cell adhesion molecules ; Cognitive ability ; Diabetes ; Diabetes mellitus ; Enzyme-linked immunosorbent assay ; Etiology ; Family Medicine ; Fibroblast growth factors ; General Practice ; Health Administration ; Inflammation ; Insulin ; Medicine ; Medicine & Public Health ; Original Article ; P-selectin ; Risk factors ; Serum levels</subject><ispartof>International journal of diabetes in developing countries, 2020-10, Vol.40 (4), p.525-531</ispartof><rights>Research Society for Study of Diabetes in India 2020</rights><rights>Research Society for Study of Diabetes in India 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-272528ada0b212200411daf4d07234db104f793df01fc6c4d31cbe8109ee755d3</citedby><cites>FETCH-LOGICAL-c319t-272528ada0b212200411daf4d07234db104f793df01fc6c4d31cbe8109ee755d3</cites><orcidid>0000-0003-4836-3786</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13410-020-00832-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13410-020-00832-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Savas, Sumru</creatorcontrib><creatorcontrib>Tayfur, Eda</creatorcontrib><creatorcontrib>Sarac, Fulden</creatorcontrib><creatorcontrib>Akbaş, Sibel</creatorcontrib><creatorcontrib>Acarer, Ahmet</creatorcontrib><creatorcontrib>Gündüz, Cumhur</creatorcontrib><creatorcontrib>Akkuş, Dilek Evyapan</creatorcontrib><creatorcontrib>Akcicek, Fehmi</creatorcontrib><title>Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients</title><title>International journal of diabetes in developing countries</title><addtitle>Int J Diabetes Dev Ctries</addtitle><description>Aim
A diverse combination of etiologies such as vascular and inflammatory factors and social and physical inactivity may take place in the etiology of cognitive dysfunction (CD). Diabetes mellitus (DM) may contribute to CD over insulin resistance, inflammation, and vascular risk factors. However, mechanisms included in the process are not very clear. We aimed to investigate serum levels of selected biomarkers as a proliferation-inducing ligand (APRIL), FGF-21, P-selectin, soluble vascular cell, and intercellular adhesion molecules-1 (sVCAM-1 and sICAM-1) in elderly patients with DM in relation to cognitive function.
Methods
A group of 80 elderly type 2 diabetic patients from the outpatient clinic, consisting of 40 patients with CD (mini-mental state examination (MMSE) score < 24) and 40 individuals without CD were enrolled in the study. Anthropometric, sociodemographic, and functional-glycemic evaluations were determined. Biomarker levels were determined by enzyme-linked immunosorbent assay.
Results
Median sICAM-1 and FGF-21 levels were higher, and P-selectin level, activities of daily living (ADL), instrumental ADL, MNA, and MMSE scores were lower in the CD group (
p
= 0.002,
p
= 0.010,
p
= 0.001,
p
= 0.001,
p
< 0.001,
p
= 0.005,
p
< 0.001, respectively). There was no significant difference between the groups regarding age, gender, living status, education, cigarette and alcohol consumption, antidiabetic therapy as well as comorbidities such as hypertension and other diseases, depression, body composition, sVCAM-1, APRIL levels, and related biochemical values.
Conclusion
Median sICAM-1 and FGF-21 levels were higher and P-selectin level was lower in older diabetic patients with CD than in patients with normal cognitive status. Understanding the mechanisms may lead to the prevention or delay of CD in those patients.</description><subject>Activities of daily living</subject><subject>Antidiabetics</subject><subject>APRIL protein</subject><subject>Biomarkers</subject><subject>Body composition</subject><subject>Cell adhesion</subject><subject>Cell adhesion molecules</subject><subject>Cognitive ability</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Etiology</subject><subject>Family Medicine</subject><subject>Fibroblast growth factors</subject><subject>General Practice</subject><subject>Health Administration</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>P-selectin</subject><subject>Risk factors</subject><subject>Serum levels</subject><issn>0973-3930</issn><issn>1998-3832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEUhYMoWKt_wFXAdfQmmWlmlqXYBxQU0XXIJHfqlGmmJjNC_71pK7hzcbkPzncuHELuOTxyAPUUucw4MBCpoJCC5RdkxMuyYDJtl2QEpZJMlhKuyU2MW4A8FxM5Iu1y2BlPp69vqzU13tH5Ys4EP43GfWJsOk93XYt2aDHSxtOAremP176jttv4pm--kdaDt6drUmDrMLQH6hpTYd9Yuk8A-j7ekqvatBHvfvuYfMyf32dLtn5ZrGbTNbOSlz0TSuSiMM5AJbgQABnnztSZAyVk5ioOWa1K6WrgtZ3YzEluKyw4lIgqz50ck4ez7z50XwPGXm-7Ifj0UotMSVWICS-SSpxVNnQxBqz1PjQ7Ew6agz6mqs-p6pSqPqWq8wTJMxST2G8w_Fn_Q_0A_nJ5bw</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Savas, Sumru</creator><creator>Tayfur, Eda</creator><creator>Sarac, Fulden</creator><creator>Akbaş, Sibel</creator><creator>Acarer, Ahmet</creator><creator>Gündüz, Cumhur</creator><creator>Akkuş, Dilek Evyapan</creator><creator>Akcicek, Fehmi</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0003-4836-3786</orcidid></search><sort><creationdate>20201001</creationdate><title>Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients</title><author>Savas, Sumru ; Tayfur, Eda ; Sarac, Fulden ; Akbaş, Sibel ; Acarer, Ahmet ; Gündüz, Cumhur ; Akkuş, Dilek Evyapan ; Akcicek, Fehmi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-272528ada0b212200411daf4d07234db104f793df01fc6c4d31cbe8109ee755d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Activities of daily living</topic><topic>Antidiabetics</topic><topic>APRIL protein</topic><topic>Biomarkers</topic><topic>Body composition</topic><topic>Cell adhesion</topic><topic>Cell adhesion molecules</topic><topic>Cognitive ability</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Etiology</topic><topic>Family Medicine</topic><topic>Fibroblast growth factors</topic><topic>General Practice</topic><topic>Health Administration</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>P-selectin</topic><topic>Risk factors</topic><topic>Serum levels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savas, Sumru</creatorcontrib><creatorcontrib>Tayfur, Eda</creatorcontrib><creatorcontrib>Sarac, Fulden</creatorcontrib><creatorcontrib>Akbaş, Sibel</creatorcontrib><creatorcontrib>Acarer, Ahmet</creatorcontrib><creatorcontrib>Gündüz, Cumhur</creatorcontrib><creatorcontrib>Akkuş, Dilek Evyapan</creatorcontrib><creatorcontrib>Akcicek, Fehmi</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>International journal of diabetes in developing countries</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savas, Sumru</au><au>Tayfur, Eda</au><au>Sarac, Fulden</au><au>Akbaş, Sibel</au><au>Acarer, Ahmet</au><au>Gündüz, Cumhur</au><au>Akkuş, Dilek Evyapan</au><au>Akcicek, Fehmi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients</atitle><jtitle>International journal of diabetes in developing countries</jtitle><stitle>Int J Diabetes Dev Ctries</stitle><date>2020-10-01</date><risdate>2020</risdate><volume>40</volume><issue>4</issue><spage>525</spage><epage>531</epage><pages>525-531</pages><issn>0973-3930</issn><eissn>1998-3832</eissn><abstract>Aim
A diverse combination of etiologies such as vascular and inflammatory factors and social and physical inactivity may take place in the etiology of cognitive dysfunction (CD). Diabetes mellitus (DM) may contribute to CD over insulin resistance, inflammation, and vascular risk factors. However, mechanisms included in the process are not very clear. We aimed to investigate serum levels of selected biomarkers as a proliferation-inducing ligand (APRIL), FGF-21, P-selectin, soluble vascular cell, and intercellular adhesion molecules-1 (sVCAM-1 and sICAM-1) in elderly patients with DM in relation to cognitive function.
Methods
A group of 80 elderly type 2 diabetic patients from the outpatient clinic, consisting of 40 patients with CD (mini-mental state examination (MMSE) score < 24) and 40 individuals without CD were enrolled in the study. Anthropometric, sociodemographic, and functional-glycemic evaluations were determined. Biomarker levels were determined by enzyme-linked immunosorbent assay.
Results
Median sICAM-1 and FGF-21 levels were higher, and P-selectin level, activities of daily living (ADL), instrumental ADL, MNA, and MMSE scores were lower in the CD group (
p
= 0.002,
p
= 0.010,
p
= 0.001,
p
= 0.001,
p
< 0.001,
p
= 0.005,
p
< 0.001, respectively). There was no significant difference between the groups regarding age, gender, living status, education, cigarette and alcohol consumption, antidiabetic therapy as well as comorbidities such as hypertension and other diseases, depression, body composition, sVCAM-1, APRIL levels, and related biochemical values.
Conclusion
Median sICAM-1 and FGF-21 levels were higher and P-selectin level was lower in older diabetic patients with CD than in patients with normal cognitive status. Understanding the mechanisms may lead to the prevention or delay of CD in those patients.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s13410-020-00832-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4836-3786</orcidid></addata></record> |
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ispartof | International journal of diabetes in developing countries, 2020-10, Vol.40 (4), p.525-531 |
issn | 0973-3930 1998-3832 |
language | eng |
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source | SpringerLink Journals - AutoHoldings |
subjects | Activities of daily living Antidiabetics APRIL protein Biomarkers Body composition Cell adhesion Cell adhesion molecules Cognitive ability Diabetes Diabetes mellitus Enzyme-linked immunosorbent assay Etiology Family Medicine Fibroblast growth factors General Practice Health Administration Inflammation Insulin Medicine Medicine & Public Health Original Article P-selectin Risk factors Serum levels |
title | Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients |
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