Amoxicillin loaded Nickel functionalized polymeric bentonite carrier for enhanced therapeutic activity

The present investigation focuses on the AMX loaded HA/Ni/Bentonite carrier to enhance the antibiotic activities. In this study, the negatively charged surface of bentonite was coated on the surface of humic acid/nickel by electrostatic attraction, leading to a remarkable improvement in the drug del...

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Veröffentlicht in:Journal of polymer research 2020, Vol.27 (12), Article 364
Hauptverfasser: Gowri, Murugesan, Latha, Nachimuthu, Suganya, Kannan, Kumar, Sadasivuni Kishor, Alahmadi, Tahani Awad, Alharbi, Sulaiman Ali, Murugan, Marudhamuthu, Rajan, Mariappan
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container_issue 12
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container_title Journal of polymer research
container_volume 27
creator Gowri, Murugesan
Latha, Nachimuthu
Suganya, Kannan
Kumar, Sadasivuni Kishor
Alahmadi, Tahani Awad
Alharbi, Sulaiman Ali
Murugan, Marudhamuthu
Rajan, Mariappan
description The present investigation focuses on the AMX loaded HA/Ni/Bentonite carrier to enhance the antibiotic activities. In this study, the negatively charged surface of bentonite was coated on the surface of humic acid/nickel by electrostatic attraction, leading to a remarkable improvement in the drug delivery applications. The resultant carrier systems were characterized using Fourier transformed infrared spectroscopy, Scanning electron microscopy, Transmission electron microscopy, X-Ray diffraction spectroscopy. XRD results showed that the particles were crystalline in nature. SEM and TEM results confirmed that the drug was encapsulated in the humic acid/nickel/bentonite carrier, and the particles were seen as spherical in shape. The AMX encapsulation and release profile were checked with UV–Visible Spectroscopy. The developed carrier achieved 90% of AMX encapsulation efficiency. The drug release studies were observed to be 67% of release in pH 2.5 and 64% release in pH 5.5 solution environment within 24 h. AMX encapsulated HA/Ni/Bentonite carrier exhibited the MIC value of 550 µg/ml and 45% of quorum sensing inhibitory activities. The colony-forming assay indicates a bacterial colonization value of 2 ± 0.5 for AMX encapsulated HA/Ni/Bentonite carrier. The interaction of AMX encapsulated HA/Ni/Bentonite carrier facilitated the drug interaction with V.cholerae species.
doi_str_mv 10.1007/s10965-020-02340-w
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In this study, the negatively charged surface of bentonite was coated on the surface of humic acid/nickel by electrostatic attraction, leading to a remarkable improvement in the drug delivery applications. The resultant carrier systems were characterized using Fourier transformed infrared spectroscopy, Scanning electron microscopy, Transmission electron microscopy, X-Ray diffraction spectroscopy. XRD results showed that the particles were crystalline in nature. SEM and TEM results confirmed that the drug was encapsulated in the humic acid/nickel/bentonite carrier, and the particles were seen as spherical in shape. The AMX encapsulation and release profile were checked with UV–Visible Spectroscopy. The developed carrier achieved 90% of AMX encapsulation efficiency. The drug release studies were observed to be 67% of release in pH 2.5 and 64% release in pH 5.5 solution environment within 24 h. AMX encapsulated HA/Ni/Bentonite carrier exhibited the MIC value of 550 µg/ml and 45% of quorum sensing inhibitory activities. The colony-forming assay indicates a bacterial colonization value of 2 ± 0.5 for AMX encapsulated HA/Ni/Bentonite carrier. 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AMX encapsulated HA/Ni/Bentonite carrier exhibited the MIC value of 550 µg/ml and 45% of quorum sensing inhibitory activities. The colony-forming assay indicates a bacterial colonization value of 2 ± 0.5 for AMX encapsulated HA/Ni/Bentonite carrier. 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subjects Amoxicillin
Antibiotics
Bentonite
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Electron microscopy
Encapsulation
Humic acids
Industrial Chemistry/Chemical Engineering
Microscopy
Nickel
Original Paper
Polymer Sciences
Spectrum analysis
title Amoxicillin loaded Nickel functionalized polymeric bentonite carrier for enhanced therapeutic activity
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