Amoxicillin loaded Nickel functionalized polymeric bentonite carrier for enhanced therapeutic activity
The present investigation focuses on the AMX loaded HA/Ni/Bentonite carrier to enhance the antibiotic activities. In this study, the negatively charged surface of bentonite was coated on the surface of humic acid/nickel by electrostatic attraction, leading to a remarkable improvement in the drug del...
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creator | Gowri, Murugesan Latha, Nachimuthu Suganya, Kannan Kumar, Sadasivuni Kishor Alahmadi, Tahani Awad Alharbi, Sulaiman Ali Murugan, Marudhamuthu Rajan, Mariappan |
description | The present investigation focuses on the AMX loaded HA/Ni/Bentonite carrier to enhance the antibiotic activities. In this study, the negatively charged surface of bentonite was coated on the surface of humic acid/nickel by electrostatic attraction, leading to a remarkable improvement in the drug delivery applications. The resultant carrier systems were characterized using Fourier transformed infrared spectroscopy, Scanning electron microscopy, Transmission electron microscopy, X-Ray diffraction spectroscopy. XRD results showed that the particles were crystalline in nature. SEM and TEM results confirmed that the drug was encapsulated in the humic acid/nickel/bentonite carrier, and the particles were seen as spherical in shape. The AMX encapsulation and release profile were checked with UV–Visible Spectroscopy. The developed carrier achieved 90% of AMX encapsulation efficiency. The drug release studies were observed to be 67% of release in pH 2.5 and 64% release in pH 5.5 solution environment within 24 h. AMX encapsulated HA/Ni/Bentonite carrier exhibited the MIC value of 550 µg/ml and 45% of quorum sensing inhibitory activities. The colony-forming assay indicates a bacterial colonization value of 2 ± 0.5 for AMX encapsulated HA/Ni/Bentonite carrier. The interaction of AMX encapsulated HA/Ni/Bentonite carrier facilitated the drug interaction with
V.cholerae
species. |
doi_str_mv | 10.1007/s10965-020-02340-w |
format | Article |
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V.cholerae
species.</description><identifier>ISSN: 1022-9760</identifier><identifier>EISSN: 1572-8935</identifier><identifier>DOI: 10.1007/s10965-020-02340-w</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Amoxicillin ; Antibiotics ; Bentonite ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Electron microscopy ; Encapsulation ; Humic acids ; Industrial Chemistry/Chemical Engineering ; Microscopy ; Nickel ; Original Paper ; Polymer Sciences ; Spectrum analysis</subject><ispartof>Journal of polymer research, 2020, Vol.27 (12), Article 364</ispartof><rights>The Polymer Society, Taipei 2020</rights><rights>The Polymer Society, Taipei 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-702cb2edfef242d3270d8948e7022026859b880a0d8eaa7259f2b14039fb17a93</citedby><cites>FETCH-LOGICAL-c356t-702cb2edfef242d3270d8948e7022026859b880a0d8eaa7259f2b14039fb17a93</cites><orcidid>0000-0001-9569-8744</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10965-020-02340-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10965-020-02340-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Gowri, Murugesan</creatorcontrib><creatorcontrib>Latha, Nachimuthu</creatorcontrib><creatorcontrib>Suganya, Kannan</creatorcontrib><creatorcontrib>Kumar, Sadasivuni Kishor</creatorcontrib><creatorcontrib>Alahmadi, Tahani Awad</creatorcontrib><creatorcontrib>Alharbi, Sulaiman Ali</creatorcontrib><creatorcontrib>Murugan, Marudhamuthu</creatorcontrib><creatorcontrib>Rajan, Mariappan</creatorcontrib><title>Amoxicillin loaded Nickel functionalized polymeric bentonite carrier for enhanced therapeutic activity</title><title>Journal of polymer research</title><addtitle>J Polym Res</addtitle><description>The present investigation focuses on the AMX loaded HA/Ni/Bentonite carrier to enhance the antibiotic activities. In this study, the negatively charged surface of bentonite was coated on the surface of humic acid/nickel by electrostatic attraction, leading to a remarkable improvement in the drug delivery applications. The resultant carrier systems were characterized using Fourier transformed infrared spectroscopy, Scanning electron microscopy, Transmission electron microscopy, X-Ray diffraction spectroscopy. XRD results showed that the particles were crystalline in nature. SEM and TEM results confirmed that the drug was encapsulated in the humic acid/nickel/bentonite carrier, and the particles were seen as spherical in shape. The AMX encapsulation and release profile were checked with UV–Visible Spectroscopy. The developed carrier achieved 90% of AMX encapsulation efficiency. The drug release studies were observed to be 67% of release in pH 2.5 and 64% release in pH 5.5 solution environment within 24 h. AMX encapsulated HA/Ni/Bentonite carrier exhibited the MIC value of 550 µg/ml and 45% of quorum sensing inhibitory activities. The colony-forming assay indicates a bacterial colonization value of 2 ± 0.5 for AMX encapsulated HA/Ni/Bentonite carrier. The interaction of AMX encapsulated HA/Ni/Bentonite carrier facilitated the drug interaction with
V.cholerae
species.</description><subject>Amoxicillin</subject><subject>Antibiotics</subject><subject>Bentonite</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Electron microscopy</subject><subject>Encapsulation</subject><subject>Humic acids</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Microscopy</subject><subject>Nickel</subject><subject>Original Paper</subject><subject>Polymer Sciences</subject><subject>Spectrum analysis</subject><issn>1022-9760</issn><issn>1572-8935</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE9PwzAMxSsEEmPwBThV4lxwk6ZpjtPEP2mCC5yjNHVYRteUpGWMT0-gSNw4WLbs33uSX5Kc53CZA_CrkIMoWQYEYtECst1BMssZJ1klKDuMMxCSCV7CcXISwgaAMV5Ws8Qstu7Datu2tktbpxps0gerX7FNzdjpwbpOtfYzbnvX7rforU5r7AbX2QFTrby36FPjfIrdWnU6gsMavepxHCKqosO7HfanyZFRbcCz3z5Pnm-un5Z32erx9n65WGWasnLIOBBdE2wMGlKQhhIOTSWKCuOBACkrJuqqAhW3qBQnTBhS5wVQYeqcK0HnycXk23v3NmIY5MaNPr4QJCk45VxwgEiRidLeheDRyN7brfJ7mYP8zlNOecqYp_zJU-6iiE6iEOHuBf2f9T-qL6Jeepk</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Gowri, Murugesan</creator><creator>Latha, Nachimuthu</creator><creator>Suganya, Kannan</creator><creator>Kumar, Sadasivuni Kishor</creator><creator>Alahmadi, Tahani Awad</creator><creator>Alharbi, Sulaiman Ali</creator><creator>Murugan, Marudhamuthu</creator><creator>Rajan, Mariappan</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0001-9569-8744</orcidid></search><sort><creationdate>2020</creationdate><title>Amoxicillin loaded Nickel functionalized polymeric bentonite carrier for enhanced therapeutic activity</title><author>Gowri, Murugesan ; Latha, Nachimuthu ; Suganya, Kannan ; Kumar, Sadasivuni Kishor ; Alahmadi, Tahani Awad ; Alharbi, Sulaiman Ali ; Murugan, Marudhamuthu ; Rajan, Mariappan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-702cb2edfef242d3270d8948e7022026859b880a0d8eaa7259f2b14039fb17a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amoxicillin</topic><topic>Antibiotics</topic><topic>Bentonite</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Electron microscopy</topic><topic>Encapsulation</topic><topic>Humic acids</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Microscopy</topic><topic>Nickel</topic><topic>Original Paper</topic><topic>Polymer Sciences</topic><topic>Spectrum analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gowri, Murugesan</creatorcontrib><creatorcontrib>Latha, Nachimuthu</creatorcontrib><creatorcontrib>Suganya, Kannan</creatorcontrib><creatorcontrib>Kumar, Sadasivuni Kishor</creatorcontrib><creatorcontrib>Alahmadi, Tahani Awad</creatorcontrib><creatorcontrib>Alharbi, Sulaiman Ali</creatorcontrib><creatorcontrib>Murugan, Marudhamuthu</creatorcontrib><creatorcontrib>Rajan, Mariappan</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of polymer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gowri, Murugesan</au><au>Latha, Nachimuthu</au><au>Suganya, Kannan</au><au>Kumar, Sadasivuni Kishor</au><au>Alahmadi, Tahani Awad</au><au>Alharbi, Sulaiman Ali</au><au>Murugan, Marudhamuthu</au><au>Rajan, Mariappan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amoxicillin loaded Nickel functionalized polymeric bentonite carrier for enhanced therapeutic activity</atitle><jtitle>Journal of polymer research</jtitle><stitle>J Polym Res</stitle><date>2020</date><risdate>2020</risdate><volume>27</volume><issue>12</issue><artnum>364</artnum><issn>1022-9760</issn><eissn>1572-8935</eissn><abstract>The present investigation focuses on the AMX loaded HA/Ni/Bentonite carrier to enhance the antibiotic activities. In this study, the negatively charged surface of bentonite was coated on the surface of humic acid/nickel by electrostatic attraction, leading to a remarkable improvement in the drug delivery applications. The resultant carrier systems were characterized using Fourier transformed infrared spectroscopy, Scanning electron microscopy, Transmission electron microscopy, X-Ray diffraction spectroscopy. XRD results showed that the particles were crystalline in nature. SEM and TEM results confirmed that the drug was encapsulated in the humic acid/nickel/bentonite carrier, and the particles were seen as spherical in shape. The AMX encapsulation and release profile were checked with UV–Visible Spectroscopy. The developed carrier achieved 90% of AMX encapsulation efficiency. The drug release studies were observed to be 67% of release in pH 2.5 and 64% release in pH 5.5 solution environment within 24 h. AMX encapsulated HA/Ni/Bentonite carrier exhibited the MIC value of 550 µg/ml and 45% of quorum sensing inhibitory activities. The colony-forming assay indicates a bacterial colonization value of 2 ± 0.5 for AMX encapsulated HA/Ni/Bentonite carrier. The interaction of AMX encapsulated HA/Ni/Bentonite carrier facilitated the drug interaction with
V.cholerae
species.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10965-020-02340-w</doi><orcidid>https://orcid.org/0000-0001-9569-8744</orcidid></addata></record> |
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subjects | Amoxicillin Antibiotics Bentonite Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Electron microscopy Encapsulation Humic acids Industrial Chemistry/Chemical Engineering Microscopy Nickel Original Paper Polymer Sciences Spectrum analysis |
title | Amoxicillin loaded Nickel functionalized polymeric bentonite carrier for enhanced therapeutic activity |
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