High-dose exposure to synthetic chemicals, hormones, or homeostatic substances in experimental animals or humans can induce artefactual pathology

The maximum tolerated dose (MTD) provides the highest probability of a positive result in a toxicology bioassay. The assumption underlying the MTD in animal bioassays is that adverse effects at very high doses are qualitatively the same as those occurring at low doses. In contrast with the MTD, the...

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Veröffentlicht in:	Toxicology Research and Application 2020-01, Vol.4
Hauptverfasser:	Smith, Carr J, Perfetti, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animal models Arteriosclerosis Atherosclerosis Bioassays Biological activity Breast Breast cancer Carcinogens Cytotoxicity Endometrial cancer Endometrium Estrogens Eutrophication Fats Fibroblasts Genotoxicity Growth factors Hormones Ingestion Mode of action Pathology Scars Stimulation Toxicity Toxicology Tumors Wound healing Xenoestrogens
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