NineTeen Complex-subunit Salsa is required for efficient splicing of a subset of introns and dorsal-ventral patterning

The NineTeen Complex (NTC), also known as pre-mRNA-processing factor 19 (Prp19) complex, regulates distinct spliceosome conformational changes necessary for splicing. During Drosophila midblastula transition, splicing is particularly sensitive to mutations in NTC-subunit Fandango, which suggests dif...

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Veröffentlicht in:	RNA (Cambridge) 2020-12, Vol.26 (12), p.1935-1956
Hauptverfasser:	Rathore, Om Singh, Silva, Rui D., Ascensao-Ferreira, Mariana, Matos, Ricardo, Carvalho, Celia, Marques, Bruno, Tiago, Margarida N., Prudencio, Pedro, Andrade, Raquel P., Roignant, Jean-Yves, Barbosa-Morais, Nuno L., Martinho, Rui Goncalo
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Animals Biochemistry & Molecular Biology Body Patterning - genetics DNA helicase DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Gene Expression Regulation, Developmental Infertility, Female - etiology Infertility, Female - metabolism Infertility, Female - pathology Insects Introns Introns - genetics Life Sciences & Biomedicine Mutation Oogenesis RNA helicase RNA Splicing Science & Technology Spliceosomes - genetics Spliceosomes - metabolism Splicing Structure-function relationships Transcription Transforming Growth Factor alpha - genetics Transforming Growth Factor alpha - metabolism
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