The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
Biomass of the acidophilic green alga Coccomyxa onubensis may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, an...
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| Veröffentlicht in: | Journal of applied phycology 2020-12, Vol.32 (6), p.3923-3931 |
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| container_title | Journal of applied phycology |
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| creator | Navarro, Francisco Toimil, Alberto Ramírez, Sara Montero, Yina Fuentes, Juan Luis Perona, Javier S. Castaño, Miguel Ángel Pásaro, Rosario Vega, José M. Vílchez, Carlos |
| description | Biomass of the acidophilic green alga
Coccomyxa onubensis
may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantly increased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement of
C. onubensis
powder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats against cardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol (26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin. The high-fat diet decreased both ω–3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however,
C. onubensis
powder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmitic and arachidonic (ω–6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the diet of rats. |
| doi_str_mv | 10.1007/s10811-020-02280-4 |
| format | Article |
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Coccomyxa onubensis
may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantly increased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement of
C. onubensis
powder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats against cardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol (26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin. The high-fat diet decreased both ω–3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however,
C. onubensis
powder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmitic and arachidonic (ω–6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the diet of rats.</description><identifier>ISSN: 0921-8971</identifier><identifier>EISSN: 1573-5176</identifier><identifier>DOI: 10.1007/s10811-020-02280-4</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acids ; Algae ; Animal tissues ; Animals ; Aquatic plants ; Atorvastatin ; Biomass ; Biomedical and Life Sciences ; Body weight ; Cholesterol ; Coccomyxa ; Diet ; Dietary fiber ; Dry weight ; Ecology ; Food sources ; Freshwater & Marine Ecology ; Glucose ; Health risks ; High fat diet ; Life Sciences ; Lipoproteins ; Low density lipoprotein ; Microalgae ; Overweight ; Plant Physiology ; Plant Sciences ; Serum ; Serum levels ; Telencephalon ; Tissue</subject><ispartof>Journal of applied phycology, 2020-12, Vol.32 (6), p.3923-3931</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2784-b2c518d05aae0fa93621193e101364921d6632b3302651d6e00c2a8a8383d67e3</citedby><cites>FETCH-LOGICAL-c2784-b2c518d05aae0fa93621193e101364921d6632b3302651d6e00c2a8a8383d67e3</cites><orcidid>0000-0002-6384-5575</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10811-020-02280-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10811-020-02280-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Navarro, Francisco</creatorcontrib><creatorcontrib>Toimil, Alberto</creatorcontrib><creatorcontrib>Ramírez, Sara</creatorcontrib><creatorcontrib>Montero, Yina</creatorcontrib><creatorcontrib>Fuentes, Juan Luis</creatorcontrib><creatorcontrib>Perona, Javier S.</creatorcontrib><creatorcontrib>Castaño, Miguel Ángel</creatorcontrib><creatorcontrib>Pásaro, Rosario</creatorcontrib><creatorcontrib>Vega, José M.</creatorcontrib><creatorcontrib>Vílchez, Carlos</creatorcontrib><title>The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets</title><title>Journal of applied phycology</title><addtitle>J Appl Phycol</addtitle><description>Biomass of the acidophilic green alga
Coccomyxa onubensis
may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantly increased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement of
C. onubensis
powder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats against cardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol (26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin. The high-fat diet decreased both ω–3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however,
C. onubensis
powder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmitic and arachidonic (ω–6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the diet of rats.</description><subject>Acids</subject><subject>Algae</subject><subject>Animal tissues</subject><subject>Animals</subject><subject>Aquatic plants</subject><subject>Atorvastatin</subject><subject>Biomass</subject><subject>Biomedical and Life Sciences</subject><subject>Body weight</subject><subject>Cholesterol</subject><subject>Coccomyxa</subject><subject>Diet</subject><subject>Dietary fiber</subject><subject>Dry weight</subject><subject>Ecology</subject><subject>Food sources</subject><subject>Freshwater & Marine Ecology</subject><subject>Glucose</subject><subject>Health risks</subject><subject>High fat diet</subject><subject>Life Sciences</subject><subject>Lipoproteins</subject><subject>Low density lipoprotein</subject><subject>Microalgae</subject><subject>Overweight</subject><subject>Plant Physiology</subject><subject>Plant Sciences</subject><subject>Serum</subject><subject>Serum levels</subject><subject>Telencephalon</subject><subject>Tissue</subject><issn>0921-8971</issn><issn>1573-5176</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9Uctu3DAMFIIWyHbbH-hJQM9uKMkP-Vgs-gIC9JKeBa5MrxV4bUfSBvUf9TPLxA1664EPETNDgSPEewUfFUBzkxRYpQrQwKEtFOWV2KmqMUWlmvqV2EGrVWHbRl2LNyndA0Brld2J33cDSfShm5chjMHLc_BxxvGE8jB7P5_XXyjn6XKkKYUkceok5jk-YsqYwyTp4YLjuMpwXuL8yFJTDsO6UDyNqycW2ygv0zEsoXseMzyTz4E51PfcJV4jI3LtqXvqh3Aaih6z7ALl9Fa87nFM9O5v3YufXz7fHb4Vtz--fj98ui28bmxZHLWvlO2gQiTosTW1Vqo1pECZuuQjdHVt9NEY0HXFDwLwGi1aY01XN2T24sOmyx98uFDK7n6-xIlXOl02xphGc9oLvaH4WClF6t0Swxnj6hS4J0fc5ohjR9yzI65kktlIicHTieI_6f-w_gCh-pHc</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Navarro, Francisco</creator><creator>Toimil, Alberto</creator><creator>Ramírez, Sara</creator><creator>Montero, Yina</creator><creator>Fuentes, Juan Luis</creator><creator>Perona, Javier S.</creator><creator>Castaño, Miguel Ángel</creator><creator>Pásaro, Rosario</creator><creator>Vega, José M.</creator><creator>Vílchez, Carlos</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TN</scope><scope>7X2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>GNUQQ</scope><scope>H95</scope><scope>HCIFZ</scope><scope>L.G</scope><scope>LK8</scope><scope>M0K</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0002-6384-5575</orcidid></search><sort><creationdate>20201201</creationdate><title>The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets</title><author>Navarro, Francisco ; 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Coccomyxa onubensis
may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantly increased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement of
C. onubensis
powder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats against cardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol (26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin. The high-fat diet decreased both ω–3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however,
C. onubensis
powder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmitic and arachidonic (ω–6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the diet of rats.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10811-020-02280-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6384-5575</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Algae Animal tissues Animals Aquatic plants Atorvastatin Biomass Biomedical and Life Sciences Body weight Cholesterol Coccomyxa Diet Dietary fiber Dry weight Ecology Food sources Freshwater & Marine Ecology Glucose Health risks High fat diet Life Sciences Lipoproteins Low density lipoprotein Microalgae Overweight Plant Physiology Plant Sciences Serum Serum levels Telencephalon Tissue |
| title | The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets |
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