Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell

5-FU is one of the key drugs in the treatment of gastric cancer (GC). Much evidence has shown that cancer stem cells (CSCs) play a key role in the acquisition of drug resistance. The organoid is a novel 3D cell culture system technology that sustains stem-cell-driven formation of near-physiological,...

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Veröffentlicht in:	Oncogene 2020-12, Vol.39 (50), p.7265-7278
Hauptverfasser:	Ukai, Shoichi, Honma, Ririno, Sakamoto, Naoya, Yamamoto, Yusuke, Pham, Quoc Thang, Harada, Kenji, Takashima, Tsuyoshi, Taniyama, Daiki, Asai, Ryuichi, Fukada, Kaho, Naka, Kazuhito, Tanabe, Kazuaki, Ohdan, Hideki, Yasui, Wataru
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/100 13/109 13/51 38/39 38/61 38/77 45/41 631/67/1504/1829 631/67/71 96/44 96/63 Aged Apoptosis Cancer CD44 antigen Cell Biology Cell culture Cell Line, Tumor Chemotherapy DNA microarrays Drug resistance Drug Resistance, Multiple Drug Resistance, Neoplasm Drug therapy Female Fluorouracil - pharmacology Gastric cancer Gene Knockout Techniques Genetic aspects Health aspects Human Genetics Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Multidrug resistance Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Oncology Organoids Organoids - drug effects Organoids - pathology Prognosis RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Stem cells Stomach cancer Stomach Neoplasms - diagnosis Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology
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