Comparison of overexpansion capabilities and thrombogenicity at the side branch ostia after implantation of four different drug eluting stents
Interventions in bifurcation lesions often requires aggressive overexpansion of stent diameter in the setting of long tapering vessel segment. Overhanging struts in front of the side branch (SB) ostium are thought to act as a focal point for thrombi formation and consequently possible stent thrombos...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2020-11, Vol.10 (1), p.20791-20791, Article 20791 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 20791 |
|---|---|
| container_issue | 1 |
| container_start_page | 20791 |
| container_title | Scientific reports |
| container_volume | 10 |
| creator | Gasior, Pawel Lu, Shengjie Ng, Chen Koon Jaryl Toong, Wee Yee Daniel Wong, En Hou Philip Foin, Nicolas Kedhi, Elvin Wojakowski, Wojciech Ang, Hui Ying |
| description | Interventions in bifurcation lesions often requires aggressive overexpansion of stent diameter in the setting of long tapering vessel segment. Overhanging struts in front of the side branch (SB) ostium are thought to act as a focal point for thrombi formation and consequently possible stent thrombosis. This study aimed to evaluate the overexpansion capabilities and thrombogenicity at the SB ostia after implantation of four latest generation drug-eluting stents (DES) in an in-vitro bifurcation model. Four clinically available modern DES were utilized: one bifurcation dedicated DES (Bioss LIM C) and three conventional DES (Ultimaster, Xience Sierra, Biomime). All devices were implanted in bifurcation models with proximal optimization ensuring expansion before perfusing with porcine blood. Optical coherence tomography (OCT), immunofluorescence (IF) and scanning electron microscope analysis were done to determine thrombogenicity and polymer coating integrity at the over-expanded part of the stents. Computational fluid dynamics (CFD) was performed to study the flow disruption. OCT (
p
= 0.113) and IF analysis (
p
= 0.007) demonstrated lowest thrombus area at SB ostia in bifurcation dedicated DES with favorable biomechanical properties compared to conventional DES. The bifurcated DES also resulted in reduced area of high shear rate and maximum shear rate in the CFD analysis. This study demonstrated numerical differences in terms of mechanical properties and acute thrombogenicity at SB ostia between tested devices. |
| doi_str_mv | 10.1038/s41598-020-75836-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_2473271859</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2473271859</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-8144a8f91b2e02be4a21bcddd43ac1539f3d054cdcb732dc8ad5c40cb3c2a0d83</originalsourceid><addsrcrecordid>eNqNkk1rFTEUhgdRbKn9Ay4k4EaQ0XzOzWwEGbQVCm50HfI5N2UmGZNMtX_C32yuU6_VhZhNwslz3nNO3jTNUwRfIUj460wR63kLMWx3jJOu7R40pxhS1mKC8cN755PmPOdrWBfDPUX94-aEEEx3GPWnzfchzotMPscAogPxxib7bZEh-xrQcpHKT754m4EMBpR9irOKow1e-3ILZKkhC7I3Fqgkg96DmIuXQLpiE_DzMslQZPGbuotrAsY7V4uEAkxaR2CntfgwglxqKD9pHjk5ZXt-t581n9-_-zRctlcfLz4Mb69azSgsLUeUSu56pLCFWFkqMVLaGEOJ1IiR3hEDGdVGqx3BRnNpmKZQK6KxhIaTs-bNprusarZG19pJTmJJfpbpVkTpxZ83we_FGG_ErusZ73AVeHEnkOKX1eYiZp-1neq8Nq5ZYNoxShjhtKLP_0Kv6zuEOl6lans7xFlfKbxROsWck3XHZhAUB8fF5riojoufjouuJj27P8Yx5Ze_FeAb8NWq6LL2Nmh7xA5fou8IQv3hd6DBb1YNcQ2lpr78_9RKk43OlQijTb-H_Ef_PwBp69xR</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473271859</pqid></control><display><type>article</type><title>Comparison of overexpansion capabilities and thrombogenicity at the side branch ostia after implantation of four different drug eluting stents</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Gasior, Pawel ; Lu, Shengjie ; Ng, Chen Koon Jaryl ; Toong, Wee Yee Daniel ; Wong, En Hou Philip ; Foin, Nicolas ; Kedhi, Elvin ; Wojakowski, Wojciech ; Ang, Hui Ying</creator><creatorcontrib>Gasior, Pawel ; Lu, Shengjie ; Ng, Chen Koon Jaryl ; Toong, Wee Yee Daniel ; Wong, En Hou Philip ; Foin, Nicolas ; Kedhi, Elvin ; Wojakowski, Wojciech ; Ang, Hui Ying</creatorcontrib><description>Interventions in bifurcation lesions often requires aggressive overexpansion of stent diameter in the setting of long tapering vessel segment. Overhanging struts in front of the side branch (SB) ostium are thought to act as a focal point for thrombi formation and consequently possible stent thrombosis. This study aimed to evaluate the overexpansion capabilities and thrombogenicity at the SB ostia after implantation of four latest generation drug-eluting stents (DES) in an in-vitro bifurcation model. Four clinically available modern DES were utilized: one bifurcation dedicated DES (Bioss LIM C) and three conventional DES (Ultimaster, Xience Sierra, Biomime). All devices were implanted in bifurcation models with proximal optimization ensuring expansion before perfusing with porcine blood. Optical coherence tomography (OCT), immunofluorescence (IF) and scanning electron microscope analysis were done to determine thrombogenicity and polymer coating integrity at the over-expanded part of the stents. Computational fluid dynamics (CFD) was performed to study the flow disruption. OCT (
p
= 0.113) and IF analysis (
p
= 0.007) demonstrated lowest thrombus area at SB ostia in bifurcation dedicated DES with favorable biomechanical properties compared to conventional DES. The bifurcated DES also resulted in reduced area of high shear rate and maximum shear rate in the CFD analysis. This study demonstrated numerical differences in terms of mechanical properties and acute thrombogenicity at SB ostia between tested devices.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-75836-6</identifier><identifier>PMID: 33247219</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/4019 ; 692/4019/2776 ; Angioplasty, Balloon, Coronary - adverse effects ; Angioplasty, Balloon, Coronary - instrumentation ; Animals ; Biomechanical Phenomena ; Computer applications ; Coronary Stenosis - pathology ; Coronary Stenosis - surgery ; Coronary Thrombosis - etiology ; Coronary Vessels - pathology ; Coronary Vessels - surgery ; Drug delivery ; Drug-Eluting Stents - adverse effects ; Fluid dynamics ; Fluorescent Antibody Technique ; Hemodynamics ; Humanities and Social Sciences ; Humans ; Hydrodynamics ; Immunofluorescence ; Implants ; In Vitro Techniques ; Mechanical properties ; Microscopy, Electron, Scanning ; Models, Cardiovascular ; multidisciplinary ; Multidisciplinary Sciences ; Polymers ; Prosthesis Design ; Scanning electron microscopy ; Science ; Science & Technology ; Science & Technology - Other Topics ; Science (multidisciplinary) ; Self Expandable Metallic Stents - adverse effects ; Stents ; Swine ; Thromboembolism ; Thrombosis ; Thrombosis - etiology ; Tomography, Optical Coherence</subject><ispartof>Scientific reports, 2020-11, Vol.10 (1), p.20791-20791, Article 20791</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>12</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000596311900001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c540t-8144a8f91b2e02be4a21bcddd43ac1539f3d054cdcb732dc8ad5c40cb3c2a0d83</citedby><cites>FETCH-LOGICAL-c540t-8144a8f91b2e02be4a21bcddd43ac1539f3d054cdcb732dc8ad5c40cb3c2a0d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695862/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695862/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2115,27929,27930,28253,41125,42194,51581,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33247219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gasior, Pawel</creatorcontrib><creatorcontrib>Lu, Shengjie</creatorcontrib><creatorcontrib>Ng, Chen Koon Jaryl</creatorcontrib><creatorcontrib>Toong, Wee Yee Daniel</creatorcontrib><creatorcontrib>Wong, En Hou Philip</creatorcontrib><creatorcontrib>Foin, Nicolas</creatorcontrib><creatorcontrib>Kedhi, Elvin</creatorcontrib><creatorcontrib>Wojakowski, Wojciech</creatorcontrib><creatorcontrib>Ang, Hui Ying</creatorcontrib><title>Comparison of overexpansion capabilities and thrombogenicity at the side branch ostia after implantation of four different drug eluting stents</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>SCI REP-UK</addtitle><addtitle>Sci Rep</addtitle><description>Interventions in bifurcation lesions often requires aggressive overexpansion of stent diameter in the setting of long tapering vessel segment. Overhanging struts in front of the side branch (SB) ostium are thought to act as a focal point for thrombi formation and consequently possible stent thrombosis. This study aimed to evaluate the overexpansion capabilities and thrombogenicity at the SB ostia after implantation of four latest generation drug-eluting stents (DES) in an in-vitro bifurcation model. Four clinically available modern DES were utilized: one bifurcation dedicated DES (Bioss LIM C) and three conventional DES (Ultimaster, Xience Sierra, Biomime). All devices were implanted in bifurcation models with proximal optimization ensuring expansion before perfusing with porcine blood. Optical coherence tomography (OCT), immunofluorescence (IF) and scanning electron microscope analysis were done to determine thrombogenicity and polymer coating integrity at the over-expanded part of the stents. Computational fluid dynamics (CFD) was performed to study the flow disruption. OCT (
p
= 0.113) and IF analysis (
p
= 0.007) demonstrated lowest thrombus area at SB ostia in bifurcation dedicated DES with favorable biomechanical properties compared to conventional DES. The bifurcated DES also resulted in reduced area of high shear rate and maximum shear rate in the CFD analysis. This study demonstrated numerical differences in terms of mechanical properties and acute thrombogenicity at SB ostia between tested devices.</description><subject>692/4019</subject><subject>692/4019/2776</subject><subject>Angioplasty, Balloon, Coronary - adverse effects</subject><subject>Angioplasty, Balloon, Coronary - instrumentation</subject><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>Computer applications</subject><subject>Coronary Stenosis - pathology</subject><subject>Coronary Stenosis - surgery</subject><subject>Coronary Thrombosis - etiology</subject><subject>Coronary Vessels - pathology</subject><subject>Coronary Vessels - surgery</subject><subject>Drug delivery</subject><subject>Drug-Eluting Stents - adverse effects</subject><subject>Fluid dynamics</subject><subject>Fluorescent Antibody Technique</subject><subject>Hemodynamics</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hydrodynamics</subject><subject>Immunofluorescence</subject><subject>Implants</subject><subject>In Vitro Techniques</subject><subject>Mechanical properties</subject><subject>Microscopy, Electron, Scanning</subject><subject>Models, Cardiovascular</subject><subject>multidisciplinary</subject><subject>Multidisciplinary Sciences</subject><subject>Polymers</subject><subject>Prosthesis Design</subject><subject>Scanning electron microscopy</subject><subject>Science</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Science (multidisciplinary)</subject><subject>Self Expandable Metallic Stents - adverse effects</subject><subject>Stents</subject><subject>Swine</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Thrombosis - etiology</subject><subject>Tomography, Optical Coherence</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk1rFTEUhgdRbKn9Ay4k4EaQ0XzOzWwEGbQVCm50HfI5N2UmGZNMtX_C32yuU6_VhZhNwslz3nNO3jTNUwRfIUj460wR63kLMWx3jJOu7R40pxhS1mKC8cN755PmPOdrWBfDPUX94-aEEEx3GPWnzfchzotMPscAogPxxib7bZEh-xrQcpHKT754m4EMBpR9irOKow1e-3ILZKkhC7I3Fqgkg96DmIuXQLpiE_DzMslQZPGbuotrAsY7V4uEAkxaR2CntfgwglxqKD9pHjk5ZXt-t581n9-_-zRctlcfLz4Mb69azSgsLUeUSu56pLCFWFkqMVLaGEOJ1IiR3hEDGdVGqx3BRnNpmKZQK6KxhIaTs-bNprusarZG19pJTmJJfpbpVkTpxZ83we_FGG_ErusZ73AVeHEnkOKX1eYiZp-1neq8Nq5ZYNoxShjhtKLP_0Kv6zuEOl6lans7xFlfKbxROsWck3XHZhAUB8fF5riojoufjouuJj27P8Yx5Ze_FeAb8NWq6LL2Nmh7xA5fou8IQv3hd6DBb1YNcQ2lpr78_9RKk43OlQijTb-H_Ef_PwBp69xR</recordid><startdate>20201127</startdate><enddate>20201127</enddate><creator>Gasior, Pawel</creator><creator>Lu, Shengjie</creator><creator>Ng, Chen Koon Jaryl</creator><creator>Toong, Wee Yee Daniel</creator><creator>Wong, En Hou Philip</creator><creator>Foin, Nicolas</creator><creator>Kedhi, Elvin</creator><creator>Wojakowski, Wojciech</creator><creator>Ang, Hui Ying</creator><general>Nature Publishing Group UK</general><general>NATURE PORTFOLIO</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201127</creationdate><title>Comparison of overexpansion capabilities and thrombogenicity at the side branch ostia after implantation of four different drug eluting stents</title><author>Gasior, Pawel ; Lu, Shengjie ; Ng, Chen Koon Jaryl ; Toong, Wee Yee Daniel ; Wong, En Hou Philip ; Foin, Nicolas ; Kedhi, Elvin ; Wojakowski, Wojciech ; Ang, Hui Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-8144a8f91b2e02be4a21bcddd43ac1539f3d054cdcb732dc8ad5c40cb3c2a0d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/4019</topic><topic>692/4019/2776</topic><topic>Angioplasty, Balloon, Coronary - adverse effects</topic><topic>Angioplasty, Balloon, Coronary - instrumentation</topic><topic>Animals</topic><topic>Biomechanical Phenomena</topic><topic>Computer applications</topic><topic>Coronary Stenosis - pathology</topic><topic>Coronary Stenosis - surgery</topic><topic>Coronary Thrombosis - etiology</topic><topic>Coronary Vessels - pathology</topic><topic>Coronary Vessels - surgery</topic><topic>Drug delivery</topic><topic>Drug-Eluting Stents - adverse effects</topic><topic>Fluid dynamics</topic><topic>Fluorescent Antibody Technique</topic><topic>Hemodynamics</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hydrodynamics</topic><topic>Immunofluorescence</topic><topic>Implants</topic><topic>In Vitro Techniques</topic><topic>Mechanical properties</topic><topic>Microscopy, Electron, Scanning</topic><topic>Models, Cardiovascular</topic><topic>multidisciplinary</topic><topic>Multidisciplinary Sciences</topic><topic>Polymers</topic><topic>Prosthesis Design</topic><topic>Scanning electron microscopy</topic><topic>Science</topic><topic>Science & Technology</topic><topic>Science & Technology - Other Topics</topic><topic>Science (multidisciplinary)</topic><topic>Self Expandable Metallic Stents - adverse effects</topic><topic>Stents</topic><topic>Swine</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><topic>Thrombosis - etiology</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gasior, Pawel</creatorcontrib><creatorcontrib>Lu, Shengjie</creatorcontrib><creatorcontrib>Ng, Chen Koon Jaryl</creatorcontrib><creatorcontrib>Toong, Wee Yee Daniel</creatorcontrib><creatorcontrib>Wong, En Hou Philip</creatorcontrib><creatorcontrib>Foin, Nicolas</creatorcontrib><creatorcontrib>Kedhi, Elvin</creatorcontrib><creatorcontrib>Wojakowski, Wojciech</creatorcontrib><creatorcontrib>Ang, Hui Ying</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gasior, Pawel</au><au>Lu, Shengjie</au><au>Ng, Chen Koon Jaryl</au><au>Toong, Wee Yee Daniel</au><au>Wong, En Hou Philip</au><au>Foin, Nicolas</au><au>Kedhi, Elvin</au><au>Wojakowski, Wojciech</au><au>Ang, Hui Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of overexpansion capabilities and thrombogenicity at the side branch ostia after implantation of four different drug eluting stents</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><stitle>SCI REP-UK</stitle><addtitle>Sci Rep</addtitle><date>2020-11-27</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>20791</spage><epage>20791</epage><pages>20791-20791</pages><artnum>20791</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Interventions in bifurcation lesions often requires aggressive overexpansion of stent diameter in the setting of long tapering vessel segment. Overhanging struts in front of the side branch (SB) ostium are thought to act as a focal point for thrombi formation and consequently possible stent thrombosis. This study aimed to evaluate the overexpansion capabilities and thrombogenicity at the SB ostia after implantation of four latest generation drug-eluting stents (DES) in an in-vitro bifurcation model. Four clinically available modern DES were utilized: one bifurcation dedicated DES (Bioss LIM C) and three conventional DES (Ultimaster, Xience Sierra, Biomime). All devices were implanted in bifurcation models with proximal optimization ensuring expansion before perfusing with porcine blood. Optical coherence tomography (OCT), immunofluorescence (IF) and scanning electron microscope analysis were done to determine thrombogenicity and polymer coating integrity at the over-expanded part of the stents. Computational fluid dynamics (CFD) was performed to study the flow disruption. OCT (
p
= 0.113) and IF analysis (
p
= 0.007) demonstrated lowest thrombus area at SB ostia in bifurcation dedicated DES with favorable biomechanical properties compared to conventional DES. The bifurcated DES also resulted in reduced area of high shear rate and maximum shear rate in the CFD analysis. This study demonstrated numerical differences in terms of mechanical properties and acute thrombogenicity at SB ostia between tested devices.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33247219</pmid><doi>10.1038/s41598-020-75836-6</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-11, Vol.10 (1), p.20791-20791, Article 20791 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_proquest_journals_2473271859 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 692/4019 692/4019/2776 Angioplasty, Balloon, Coronary - adverse effects Angioplasty, Balloon, Coronary - instrumentation Animals Biomechanical Phenomena Computer applications Coronary Stenosis - pathology Coronary Stenosis - surgery Coronary Thrombosis - etiology Coronary Vessels - pathology Coronary Vessels - surgery Drug delivery Drug-Eluting Stents - adverse effects Fluid dynamics Fluorescent Antibody Technique Hemodynamics Humanities and Social Sciences Humans Hydrodynamics Immunofluorescence Implants In Vitro Techniques Mechanical properties Microscopy, Electron, Scanning Models, Cardiovascular multidisciplinary Multidisciplinary Sciences Polymers Prosthesis Design Scanning electron microscopy Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Self Expandable Metallic Stents - adverse effects Stents Swine Thromboembolism Thrombosis Thrombosis - etiology Tomography, Optical Coherence |
| title | Comparison of overexpansion capabilities and thrombogenicity at the side branch ostia after implantation of four different drug eluting stents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T03%3A03%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20overexpansion%20capabilities%20and%20thrombogenicity%20at%20the%20side%20branch%20ostia%20after%20implantation%20of%20four%20different%20drug%20eluting%20stents&rft.jtitle=Scientific%20reports&rft.au=Gasior,%20Pawel&rft.date=2020-11-27&rft.volume=10&rft.issue=1&rft.spage=20791&rft.epage=20791&rft.pages=20791-20791&rft.artnum=20791&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-75836-6&rft_dat=%3Cproquest_pubme%3E2473271859%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2473271859&rft_id=info:pmid/33247219&rfr_iscdi=true |