Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington’s disease patients

In Huntington’s disease (HD), the mutant Huntingtin (mHTT) is postulated to mediate template-based aggregation that can propagate across cells. It has been difficult to quantitatively detect such pathological seeding activities in patient biosamples, e.g. cerebrospinal fluids (CSF), and study their...

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Veröffentlicht in:	Scientific reports 2020-11, Vol.10 (1), p.20295-20295, Article 20295
Hauptverfasser:	Lee, C. Y. Daniel, Wang, Nan, Shen, Koning, Stricos, Matthew, Langfelder, Peter, Cheon, Kristina H., Cortés, Etty P., Vinters, Harry V., Vonsattel, Jean Paul, Wexler, Nancy S., Damoiseaux, Robert, Frydman, Judith, Yang, X. William
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2421 692/617 692/699 692/699/375/1558 Adult Aged Aged, 80 and over Alzheimer's disease Antibodies Brain - pathology Cell Line Cerebrospinal fluid Cerebrospinal Fluid - metabolism Exons - genetics Female Genes, Reporter - genetics HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism Humanities and Social Sciences Humans Huntingtin Huntingtin Protein - cerebrospinal fluid Huntingtin Protein - genetics Huntingtin Protein - metabolism Huntington Disease - cerebrospinal fluid Huntington Disease - genetics Huntington Disease - pathology Huntington's disease Huntingtons disease Intravital Microscopy Male Middle Aged Molecular Chaperones - genetics Molecular Chaperones - metabolism multidisciplinary Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurology Neuropathology Patients Polyproline Protein Aggregation, Pathological - cerebrospinal fluid Protein Aggregation, Pathological - genetics Protein Aggregation, Pathological - pathology Protein Domains - genetics Protein Engineering Protein Folding Proteins Science Science (multidisciplinary) Seeds Species
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