Regulation of human β-galactoside α2,6-sialyltransferase (hST6Gal I) gene expression during differentiation of human osteoblastic MG-63 cells
In this study, we found that gene expression of the human β-galactoside α2,6-sialyltransferase (hST6Gal I) was specifically increased during differentiation of human MG-63 osteoblastic cells by serum starvation (SS). In parallel, a distinct increase in binding to SNA, the α2,6-sialyl-specific lectin...
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| Veröffentlicht in: | Glycoconjugate journal 2020-12, Vol.37 (6), p.681-690 |
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| creator | An, So-Young Lee, Miri Yoon, Hyun-Kyoung Abekura, Fukushi Kim, Kyoung-Sook Kim, Dong-Hyun Kim, Hyeon-Jun Lee, Kichoon Kim, Cheorl-Ho Lee, Young-Choon |
| description | In this study, we found that gene expression of the human β-galactoside α2,6-sialyltransferase (hST6Gal I) was specifically increased during differentiation of human MG-63 osteoblastic cells by serum starvation (SS). In parallel, a distinct increase in binding to SNA, the α2,6-sialyl-specific lectin, was observed in serum-starved cells, as demonstrated by FACS analysis. 5’-Rapid amplification of cDNA ends analysis demonstrated that the increase of hST6Gal I transcript by SS is mediated by P1 promoter. To elucidate transcriptional regulation of hST6Gal I in SS-induced MG-63 cells, we functionally characterized the P1 promoter region of the hST6Gal I gene. The 5’-deletion analysis of P1 promoter region revealed that the 189 bp upstream region of transcription start site is critical for transcriptional activity of hST6Gal I gene in SS-induced MG-63 cells. This region contains the predicted binding sites for several transcription factors, including AREB6, FOXP1, SIX3, HNF1, YY2, and MOK2. The mutagenesis analysis for these sites and chromatin immunoprecipitation assay demonstrated that the YY2 binding site at -98 to -77 was essential for the SS-induced hST6Gal I gene expression during differentiation of MG-63 cells. |
| doi_str_mv | 10.1007/s10719-020-09959-3 |
| format | Article |
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In parallel, a distinct increase in binding to SNA, the α2,6-sialyl-specific lectin, was observed in serum-starved cells, as demonstrated by FACS analysis. 5’-Rapid amplification of cDNA ends analysis demonstrated that the increase of hST6Gal I transcript by SS is mediated by P1 promoter. To elucidate transcriptional regulation of hST6Gal I in SS-induced MG-63 cells, we functionally characterized the P1 promoter region of the hST6Gal I gene. The 5’-deletion analysis of P1 promoter region revealed that the 189 bp upstream region of transcription start site is critical for transcriptional activity of hST6Gal I gene in SS-induced MG-63 cells. This region contains the predicted binding sites for several transcription factors, including AREB6, FOXP1, SIX3, HNF1, YY2, and MOK2. The mutagenesis analysis for these sites and chromatin immunoprecipitation assay demonstrated that the YY2 binding site at -98 to -77 was essential for the SS-induced hST6Gal I gene expression during differentiation of MG-63 cells.</description><identifier>ISSN: 0282-0080</identifier><identifier>EISSN: 1573-4986</identifier><identifier>DOI: 10.1007/s10719-020-09959-3</identifier><identifier>PMID: 33108606</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antigens, CD - genetics ; Binding sites ; Biochemistry ; Biomedical and Life Sciences ; Cell differentiation ; Cell Differentiation - genetics ; Chromatin ; DNA-Binding Proteins - genetics ; Eye Proteins - genetics ; Flow cytometry ; Forkhead Transcription Factors - genetics ; Foxp1 protein ; Gene deletion ; Gene expression ; Gene Expression Regulation, Developmental - genetics ; Gene Expression Regulation, Enzymologic - genetics ; Gene regulation ; Homeobox Protein SIX3 ; Homeodomain Proteins - genetics ; Humans ; Immunoprecipitation ; Life Sciences ; Mutagenesis ; Nerve Tissue Proteins - genetics ; Original Article ; Osteoblastogenesis ; Osteoblasts ; Osteoblasts - cytology ; Osteoblasts - metabolism ; Pathology ; Promoter Regions, Genetic - genetics ; Repressor Proteins - genetics ; Sialyltransferases - genetics ; Six3 gene ; Transcription factors ; Transcription Factors - genetics ; Transcription Initiation Site ; Transcription, Genetic ; Zinc Finger E-box-Binding Homeobox 1 - genetics</subject><ispartof>Glycoconjugate journal, 2020-12, Vol.37 (6), p.681-690</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e256446da26f62a32ec887d6801c127490309583c24b3d7b909207e66ee183553</citedby><cites>FETCH-LOGICAL-c375t-e256446da26f62a32ec887d6801c127490309583c24b3d7b909207e66ee183553</cites><orcidid>0000-0002-6323-0714</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10719-020-09959-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10719-020-09959-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33108606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>An, So-Young</creatorcontrib><creatorcontrib>Lee, Miri</creatorcontrib><creatorcontrib>Yoon, Hyun-Kyoung</creatorcontrib><creatorcontrib>Abekura, Fukushi</creatorcontrib><creatorcontrib>Kim, Kyoung-Sook</creatorcontrib><creatorcontrib>Kim, Dong-Hyun</creatorcontrib><creatorcontrib>Kim, Hyeon-Jun</creatorcontrib><creatorcontrib>Lee, Kichoon</creatorcontrib><creatorcontrib>Kim, Cheorl-Ho</creatorcontrib><creatorcontrib>Lee, Young-Choon</creatorcontrib><title>Regulation of human β-galactoside α2,6-sialyltransferase (hST6Gal I) gene expression during differentiation of human osteoblastic MG-63 cells</title><title>Glycoconjugate journal</title><addtitle>Glycoconj J</addtitle><addtitle>Glycoconj J</addtitle><description>In this study, we found that gene expression of the human β-galactoside α2,6-sialyltransferase (hST6Gal I) was specifically increased during differentiation of human MG-63 osteoblastic cells by serum starvation (SS). In parallel, a distinct increase in binding to SNA, the α2,6-sialyl-specific lectin, was observed in serum-starved cells, as demonstrated by FACS analysis. 5’-Rapid amplification of cDNA ends analysis demonstrated that the increase of hST6Gal I transcript by SS is mediated by P1 promoter. To elucidate transcriptional regulation of hST6Gal I in SS-induced MG-63 cells, we functionally characterized the P1 promoter region of the hST6Gal I gene. The 5’-deletion analysis of P1 promoter region revealed that the 189 bp upstream region of transcription start site is critical for transcriptional activity of hST6Gal I gene in SS-induced MG-63 cells. This region contains the predicted binding sites for several transcription factors, including AREB6, FOXP1, SIX3, HNF1, YY2, and MOK2. The mutagenesis analysis for these sites and chromatin immunoprecipitation assay demonstrated that the YY2 binding site at -98 to -77 was essential for the SS-induced hST6Gal I gene expression during differentiation of MG-63 cells.</description><subject>Antigens, CD - genetics</subject><subject>Binding sites</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - genetics</subject><subject>Chromatin</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Eye Proteins - genetics</subject><subject>Flow cytometry</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Foxp1 protein</subject><subject>Gene deletion</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>Gene Expression Regulation, Enzymologic - genetics</subject><subject>Gene regulation</subject><subject>Homeobox Protein SIX3</subject><subject>Homeodomain Proteins - genetics</subject><subject>Humans</subject><subject>Immunoprecipitation</subject><subject>Life Sciences</subject><subject>Mutagenesis</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Original Article</subject><subject>Osteoblastogenesis</subject><subject>Osteoblasts</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - metabolism</subject><subject>Pathology</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Repressor Proteins - genetics</subject><subject>Sialyltransferases - genetics</subject><subject>Six3 gene</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Initiation Site</subject><subject>Transcription, Genetic</subject><subject>Zinc Finger E-box-Binding Homeobox 1 - genetics</subject><issn>0282-0080</issn><issn>1573-4986</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1q3EAUhJsQY49_LpBFaPAmhnTyulvqn2UwycRgY0jsddMjPY1leqRxPwniU-QsyUF8pmgydgxeZFWbr6qgirE3Ej5IAPuRJFjpBSgQ4H3phX7FZrK0WhTemddsBsopAeBgj-0T3cJkKpTbZXtaS3AGzIz9_IbLMcWh7TveN_xmXMWOP_wWy5hiNfTU1sgffqn3RlAb030acuyowRwJ-bub71dmHhM_O-FL7JDjj3VGok1WPea2W_K6bSYYu6F9UdHTgP0iRRrail_MhdG8wpTokO00MREePeoBu_7y-er0qzi_nJ-dfjoXlbblIFCVpihMHZVpjIpaYeWcrY0DWUllCw8afOl0pYqFru3Cg1dg0RhE6XRZ6gN2vM1d5_5uRBrCbT_mbqoMqrBaKZg2mii1parcE2Vswjq3q5jvg4Sw-SBsPwjTB-HvB0FPpreP0eNihfU_y9PoE6C3AK03I2F-7v5P7B8_spKh</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>An, So-Young</creator><creator>Lee, Miri</creator><creator>Yoon, Hyun-Kyoung</creator><creator>Abekura, Fukushi</creator><creator>Kim, Kyoung-Sook</creator><creator>Kim, Dong-Hyun</creator><creator>Kim, Hyeon-Jun</creator><creator>Lee, Kichoon</creator><creator>Kim, Cheorl-Ho</creator><creator>Lee, Young-Choon</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-6323-0714</orcidid></search><sort><creationdate>20201201</creationdate><title>Regulation of human β-galactoside α2,6-sialyltransferase (hST6Gal I) gene expression during differentiation of human osteoblastic MG-63 cells</title><author>An, So-Young ; Lee, Miri ; Yoon, Hyun-Kyoung ; Abekura, Fukushi ; Kim, Kyoung-Sook ; Kim, Dong-Hyun ; Kim, Hyeon-Jun ; Lee, Kichoon ; Kim, Cheorl-Ho ; Lee, Young-Choon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e256446da26f62a32ec887d6801c127490309583c24b3d7b909207e66ee183553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antigens, CD - 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metabolism</topic><topic>Pathology</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Repressor Proteins - genetics</topic><topic>Sialyltransferases - genetics</topic><topic>Six3 gene</topic><topic>Transcription factors</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Initiation Site</topic><topic>Transcription, Genetic</topic><topic>Zinc Finger E-box-Binding Homeobox 1 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>An, So-Young</creatorcontrib><creatorcontrib>Lee, Miri</creatorcontrib><creatorcontrib>Yoon, Hyun-Kyoung</creatorcontrib><creatorcontrib>Abekura, Fukushi</creatorcontrib><creatorcontrib>Kim, Kyoung-Sook</creatorcontrib><creatorcontrib>Kim, Dong-Hyun</creatorcontrib><creatorcontrib>Kim, Hyeon-Jun</creatorcontrib><creatorcontrib>Lee, Kichoon</creatorcontrib><creatorcontrib>Kim, Cheorl-Ho</creatorcontrib><creatorcontrib>Lee, Young-Choon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Glycoconjugate journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>An, So-Young</au><au>Lee, Miri</au><au>Yoon, Hyun-Kyoung</au><au>Abekura, Fukushi</au><au>Kim, Kyoung-Sook</au><au>Kim, Dong-Hyun</au><au>Kim, Hyeon-Jun</au><au>Lee, Kichoon</au><au>Kim, Cheorl-Ho</au><au>Lee, Young-Choon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of human β-galactoside α2,6-sialyltransferase (hST6Gal I) gene expression during differentiation of human osteoblastic MG-63 cells</atitle><jtitle>Glycoconjugate journal</jtitle><stitle>Glycoconj J</stitle><addtitle>Glycoconj J</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>37</volume><issue>6</issue><spage>681</spage><epage>690</epage><pages>681-690</pages><issn>0282-0080</issn><eissn>1573-4986</eissn><abstract>In this study, we found that gene expression of the human β-galactoside α2,6-sialyltransferase (hST6Gal I) was specifically increased during differentiation of human MG-63 osteoblastic cells by serum starvation (SS). In parallel, a distinct increase in binding to SNA, the α2,6-sialyl-specific lectin, was observed in serum-starved cells, as demonstrated by FACS analysis. 5’-Rapid amplification of cDNA ends analysis demonstrated that the increase of hST6Gal I transcript by SS is mediated by P1 promoter. To elucidate transcriptional regulation of hST6Gal I in SS-induced MG-63 cells, we functionally characterized the P1 promoter region of the hST6Gal I gene. The 5’-deletion analysis of P1 promoter region revealed that the 189 bp upstream region of transcription start site is critical for transcriptional activity of hST6Gal I gene in SS-induced MG-63 cells. This region contains the predicted binding sites for several transcription factors, including AREB6, FOXP1, SIX3, HNF1, YY2, and MOK2. The mutagenesis analysis for these sites and chromatin immunoprecipitation assay demonstrated that the YY2 binding site at -98 to -77 was essential for the SS-induced hST6Gal I gene expression during differentiation of MG-63 cells.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33108606</pmid><doi>10.1007/s10719-020-09959-3</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6323-0714</orcidid></addata></record> |
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| subjects | Antigens, CD - genetics Binding sites Biochemistry Biomedical and Life Sciences Cell differentiation Cell Differentiation - genetics Chromatin DNA-Binding Proteins - genetics Eye Proteins - genetics Flow cytometry Forkhead Transcription Factors - genetics Foxp1 protein Gene deletion Gene expression Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Enzymologic - genetics Gene regulation Homeobox Protein SIX3 Homeodomain Proteins - genetics Humans Immunoprecipitation Life Sciences Mutagenesis Nerve Tissue Proteins - genetics Original Article Osteoblastogenesis Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Pathology Promoter Regions, Genetic - genetics Repressor Proteins - genetics Sialyltransferases - genetics Six3 gene Transcription factors Transcription Factors - genetics Transcription Initiation Site Transcription, Genetic Zinc Finger E-box-Binding Homeobox 1 - genetics |
| title | Regulation of human β-galactoside α2,6-sialyltransferase (hST6Gal I) gene expression during differentiation of human osteoblastic MG-63 cells |
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