Intraindividual comparison of 18F‐FDOPA and 68Ga‐DOTATOC PET/CT detection rate for metastatic assessment in patients with ileal neuroendocrine tumours
Introduction In patients with ileal neuroendocrine tumours (ileal NETs), head‐to‐head evaluation of diagnostic performances of 68Ga‐DOTA‐peptides and 18F‐fluorodihydroxyphenylalanine (18F‐FDOPA) positron emission tomography/computed tomography (PET/CT) has been performed in only few small patients’...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2021-01, Vol.94 (1), p.66-73 |
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| creator | Ouvrard, Eric Chevalier, Elodie Addeo, Pietro Sahakian, Nicolas Detour, Julien Goichot, Bernard Bachellier, Philippe Karcher, Gilles Taïeb, David Imperiale, Alessio |
| description | Introduction
In patients with ileal neuroendocrine tumours (ileal NETs), head‐to‐head evaluation of diagnostic performances of 68Ga‐DOTA‐peptides and 18F‐fluorodihydroxyphenylalanine (18F‐FDOPA) positron emission tomography/computed tomography (PET/CT) has been performed in only few small patients’ cohorts. The aim of this retrospective study was to compare 68Ga‐DOTATOC and 18F‐FDOPA PET/CT for metastatic disease assessment in a homogeneous large series of patients with well‐differentiated ileal NETs.
Methods
All patients with ileal NETs who underwent both 18F‐FDOPA and 68Ga‐DOTATOC PET/CT within a 3‐month period and no therapeutic change between the two studies were retrospectively included. The detection rates of both modalities were calculated using per‐patient, per‐region and per‐lesion analyses.
Results
Forty one patients with ileal NETs were evaluated. 18F‐FDOPA and 68Ga‐DOTATOC showed similar detection rates according to per‐patient (97% for both) and per‐region analyses (94% for 18F‐FDOPA vs 88% for 68Ga‐DOTATOC, P = .35). For a total of 605 positive lesions, 458 (76%) were detected by both modalities, 122 (20%) exclusively by 18F‐FDOPA PET/CT, and 25 (4%) by 68Ga‐DOTATOC PET/CT only. In a per‐lesion analysis, 18F‐FDOPA PET/CT performed better than 68Ga‐DOTATOC PET/CT (overall detection rates of 96% vs 80%; P |
| doi_str_mv | 10.1111/cen.14312 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_proquest_journals_2472839335</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2472839335</sourcerecordid><originalsourceid>FETCH-LOGICAL-p682-9841e0749fe4979f11cc8bf85fd74f42b0ceee71474259b38a557165d6bdc2f63</originalsourceid><addsrcrecordid>eNotUMtu2zAQJIoUqOP20D8g0LNivkUdDcV2AwSxD7oLNLVEGViUSlINcusn5NzP65eUTbKXHQxmdwaD0FdKbmiZjYVwQwWn7ANaUa5kxZiSV2hFOCEVUUp8QtcpPRJCpCb1Cv25CzkaHwb_yw-LuWA7jbOJPk0BTw5Tvf_7-2V_ezxtsQkDVvpgCnF77LbdscWnXbdpOzxABpt9OYkmA3ZTxCNkk7LJ3mKTEqQ0QsjYBzwXrsCEn3z-gf0FimeAJU4QhslGHwDnZZyWmD6jj85cEnx532vU7Xdd-726Px7u2u19NSvNqkYLCqQWjQPR1I2j1Fp9dlq6oRZOsDOxAFBTUQsmmzPXRsqaKjmo82CZU3yNvr29neP0c4GU-8fiHopjz0TNNG84l0W1eVM9lcjP_Rz9aOJzT0n_v_a-1N6_1t63u4dXwP8Bo9l6Cg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2472839335</pqid></control><display><type>article</type><title>Intraindividual comparison of 18F‐FDOPA and 68Ga‐DOTATOC PET/CT detection rate for metastatic assessment in patients with ileal neuroendocrine tumours</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ouvrard, Eric ; Chevalier, Elodie ; Addeo, Pietro ; Sahakian, Nicolas ; Detour, Julien ; Goichot, Bernard ; Bachellier, Philippe ; Karcher, Gilles ; Taïeb, David ; Imperiale, Alessio</creator><creatorcontrib>Ouvrard, Eric ; Chevalier, Elodie ; Addeo, Pietro ; Sahakian, Nicolas ; Detour, Julien ; Goichot, Bernard ; Bachellier, Philippe ; Karcher, Gilles ; Taïeb, David ; Imperiale, Alessio</creatorcontrib><description>Introduction
In patients with ileal neuroendocrine tumours (ileal NETs), head‐to‐head evaluation of diagnostic performances of 68Ga‐DOTA‐peptides and 18F‐fluorodihydroxyphenylalanine (18F‐FDOPA) positron emission tomography/computed tomography (PET/CT) has been performed in only few small patients’ cohorts. The aim of this retrospective study was to compare 68Ga‐DOTATOC and 18F‐FDOPA PET/CT for metastatic disease assessment in a homogeneous large series of patients with well‐differentiated ileal NETs.
Methods
All patients with ileal NETs who underwent both 18F‐FDOPA and 68Ga‐DOTATOC PET/CT within a 3‐month period and no therapeutic change between the two studies were retrospectively included. The detection rates of both modalities were calculated using per‐patient, per‐region and per‐lesion analyses.
Results
Forty one patients with ileal NETs were evaluated. 18F‐FDOPA and 68Ga‐DOTATOC showed similar detection rates according to per‐patient (97% for both) and per‐region analyses (94% for 18F‐FDOPA vs 88% for 68Ga‐DOTATOC, P = .35). For a total of 605 positive lesions, 458 (76%) were detected by both modalities, 122 (20%) exclusively by 18F‐FDOPA PET/CT, and 25 (4%) by 68Ga‐DOTATOC PET/CT only. In a per‐lesion analysis, 18F‐FDOPA PET/CT performed better than 68Ga‐DOTATOC PET/CT (overall detection rates of 96% vs 80%; P < .001). 18F‐FDOPA PET/CT detected significantly more metastases than 68Ga‐DOTATOC PET/CT in the liver, peritoneum, abdominal and supra‐diaphragmatic lymph nodes.
Conclusion
18F‐FDOPA PET/CT seems not inferior than 68Ga‐DOTATOC PET/CT for the delineation of metastatic spread of ileal NETs. Therefore, according to local expertise and technical availability, 18F‐FDOPA should be considered as a valid clinical diagnostic option for exhaustive metastatic assessment in patients with ileal NETs. Obviously, 68Ga‐DOTATOC PET/CT remains mandatory for PRRT assessment. Further comparative studies are needed to determine the optimal approach in various clinical scenarios such as preoperative staging and primary tumour detection.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.14312</identifier><language>eng</language><publisher>Oxford: Wiley Subscription Services, Inc</publisher><subject>18F‐FDOPA ; 68Ga‐DOTATOC ; carcinoid ; Computed tomography ; Lesions ; Lymph nodes ; Metastases ; Metastasis ; Neuroendocrine tumors ; neuroendocrine tumours ; Patients ; Peritoneum ; Positron emission tomography ; small‐intestine ; Tomography</subject><ispartof>Clinical endocrinology (Oxford), 2021-01, Vol.94 (1), p.66-73</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.14312$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.14312$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Ouvrard, Eric</creatorcontrib><creatorcontrib>Chevalier, Elodie</creatorcontrib><creatorcontrib>Addeo, Pietro</creatorcontrib><creatorcontrib>Sahakian, Nicolas</creatorcontrib><creatorcontrib>Detour, Julien</creatorcontrib><creatorcontrib>Goichot, Bernard</creatorcontrib><creatorcontrib>Bachellier, Philippe</creatorcontrib><creatorcontrib>Karcher, Gilles</creatorcontrib><creatorcontrib>Taïeb, David</creatorcontrib><creatorcontrib>Imperiale, Alessio</creatorcontrib><title>Intraindividual comparison of 18F‐FDOPA and 68Ga‐DOTATOC PET/CT detection rate for metastatic assessment in patients with ileal neuroendocrine tumours</title><title>Clinical endocrinology (Oxford)</title><description>Introduction
In patients with ileal neuroendocrine tumours (ileal NETs), head‐to‐head evaluation of diagnostic performances of 68Ga‐DOTA‐peptides and 18F‐fluorodihydroxyphenylalanine (18F‐FDOPA) positron emission tomography/computed tomography (PET/CT) has been performed in only few small patients’ cohorts. The aim of this retrospective study was to compare 68Ga‐DOTATOC and 18F‐FDOPA PET/CT for metastatic disease assessment in a homogeneous large series of patients with well‐differentiated ileal NETs.
Methods
All patients with ileal NETs who underwent both 18F‐FDOPA and 68Ga‐DOTATOC PET/CT within a 3‐month period and no therapeutic change between the two studies were retrospectively included. The detection rates of both modalities were calculated using per‐patient, per‐region and per‐lesion analyses.
Results
Forty one patients with ileal NETs were evaluated. 18F‐FDOPA and 68Ga‐DOTATOC showed similar detection rates according to per‐patient (97% for both) and per‐region analyses (94% for 18F‐FDOPA vs 88% for 68Ga‐DOTATOC, P = .35). For a total of 605 positive lesions, 458 (76%) were detected by both modalities, 122 (20%) exclusively by 18F‐FDOPA PET/CT, and 25 (4%) by 68Ga‐DOTATOC PET/CT only. In a per‐lesion analysis, 18F‐FDOPA PET/CT performed better than 68Ga‐DOTATOC PET/CT (overall detection rates of 96% vs 80%; P < .001). 18F‐FDOPA PET/CT detected significantly more metastases than 68Ga‐DOTATOC PET/CT in the liver, peritoneum, abdominal and supra‐diaphragmatic lymph nodes.
Conclusion
18F‐FDOPA PET/CT seems not inferior than 68Ga‐DOTATOC PET/CT for the delineation of metastatic spread of ileal NETs. Therefore, according to local expertise and technical availability, 18F‐FDOPA should be considered as a valid clinical diagnostic option for exhaustive metastatic assessment in patients with ileal NETs. Obviously, 68Ga‐DOTATOC PET/CT remains mandatory for PRRT assessment. Further comparative studies are needed to determine the optimal approach in various clinical scenarios such as preoperative staging and primary tumour detection.</description><subject>18F‐FDOPA</subject><subject>68Ga‐DOTATOC</subject><subject>carcinoid</subject><subject>Computed tomography</subject><subject>Lesions</subject><subject>Lymph nodes</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Neuroendocrine tumors</subject><subject>neuroendocrine tumours</subject><subject>Patients</subject><subject>Peritoneum</subject><subject>Positron emission tomography</subject><subject>small‐intestine</subject><subject>Tomography</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNotUMtu2zAQJIoUqOP20D8g0LNivkUdDcV2AwSxD7oLNLVEGViUSlINcusn5NzP65eUTbKXHQxmdwaD0FdKbmiZjYVwQwWn7ANaUa5kxZiSV2hFOCEVUUp8QtcpPRJCpCb1Cv25CzkaHwb_yw-LuWA7jbOJPk0BTw5Tvf_7-2V_ezxtsQkDVvpgCnF77LbdscWnXbdpOzxABpt9OYkmA3ZTxCNkk7LJ3mKTEqQ0QsjYBzwXrsCEn3z-gf0FimeAJU4QhslGHwDnZZyWmD6jj85cEnx532vU7Xdd-726Px7u2u19NSvNqkYLCqQWjQPR1I2j1Fp9dlq6oRZOsDOxAFBTUQsmmzPXRsqaKjmo82CZU3yNvr29neP0c4GU-8fiHopjz0TNNG84l0W1eVM9lcjP_Rz9aOJzT0n_v_a-1N6_1t63u4dXwP8Bo9l6Cg</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Ouvrard, Eric</creator><creator>Chevalier, Elodie</creator><creator>Addeo, Pietro</creator><creator>Sahakian, Nicolas</creator><creator>Detour, Julien</creator><creator>Goichot, Bernard</creator><creator>Bachellier, Philippe</creator><creator>Karcher, Gilles</creator><creator>Taïeb, David</creator><creator>Imperiale, Alessio</creator><general>Wiley Subscription Services, Inc</general><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>202101</creationdate><title>Intraindividual comparison of 18F‐FDOPA and 68Ga‐DOTATOC PET/CT detection rate for metastatic assessment in patients with ileal neuroendocrine tumours</title><author>Ouvrard, Eric ; Chevalier, Elodie ; Addeo, Pietro ; Sahakian, Nicolas ; Detour, Julien ; Goichot, Bernard ; Bachellier, Philippe ; Karcher, Gilles ; Taïeb, David ; Imperiale, Alessio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p682-9841e0749fe4979f11cc8bf85fd74f42b0ceee71474259b38a557165d6bdc2f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>18F‐FDOPA</topic><topic>68Ga‐DOTATOC</topic><topic>carcinoid</topic><topic>Computed tomography</topic><topic>Lesions</topic><topic>Lymph nodes</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Neuroendocrine tumors</topic><topic>neuroendocrine tumours</topic><topic>Patients</topic><topic>Peritoneum</topic><topic>Positron emission tomography</topic><topic>small‐intestine</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ouvrard, Eric</creatorcontrib><creatorcontrib>Chevalier, Elodie</creatorcontrib><creatorcontrib>Addeo, Pietro</creatorcontrib><creatorcontrib>Sahakian, Nicolas</creatorcontrib><creatorcontrib>Detour, Julien</creatorcontrib><creatorcontrib>Goichot, Bernard</creatorcontrib><creatorcontrib>Bachellier, Philippe</creatorcontrib><creatorcontrib>Karcher, Gilles</creatorcontrib><creatorcontrib>Taïeb, David</creatorcontrib><creatorcontrib>Imperiale, Alessio</creatorcontrib><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ouvrard, Eric</au><au>Chevalier, Elodie</au><au>Addeo, Pietro</au><au>Sahakian, Nicolas</au><au>Detour, Julien</au><au>Goichot, Bernard</au><au>Bachellier, Philippe</au><au>Karcher, Gilles</au><au>Taïeb, David</au><au>Imperiale, Alessio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraindividual comparison of 18F‐FDOPA and 68Ga‐DOTATOC PET/CT detection rate for metastatic assessment in patients with ileal neuroendocrine tumours</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><date>2021-01</date><risdate>2021</risdate><volume>94</volume><issue>1</issue><spage>66</spage><epage>73</epage><pages>66-73</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Introduction
In patients with ileal neuroendocrine tumours (ileal NETs), head‐to‐head evaluation of diagnostic performances of 68Ga‐DOTA‐peptides and 18F‐fluorodihydroxyphenylalanine (18F‐FDOPA) positron emission tomography/computed tomography (PET/CT) has been performed in only few small patients’ cohorts. The aim of this retrospective study was to compare 68Ga‐DOTATOC and 18F‐FDOPA PET/CT for metastatic disease assessment in a homogeneous large series of patients with well‐differentiated ileal NETs.
Methods
All patients with ileal NETs who underwent both 18F‐FDOPA and 68Ga‐DOTATOC PET/CT within a 3‐month period and no therapeutic change between the two studies were retrospectively included. The detection rates of both modalities were calculated using per‐patient, per‐region and per‐lesion analyses.
Results
Forty one patients with ileal NETs were evaluated. 18F‐FDOPA and 68Ga‐DOTATOC showed similar detection rates according to per‐patient (97% for both) and per‐region analyses (94% for 18F‐FDOPA vs 88% for 68Ga‐DOTATOC, P = .35). For a total of 605 positive lesions, 458 (76%) were detected by both modalities, 122 (20%) exclusively by 18F‐FDOPA PET/CT, and 25 (4%) by 68Ga‐DOTATOC PET/CT only. In a per‐lesion analysis, 18F‐FDOPA PET/CT performed better than 68Ga‐DOTATOC PET/CT (overall detection rates of 96% vs 80%; P < .001). 18F‐FDOPA PET/CT detected significantly more metastases than 68Ga‐DOTATOC PET/CT in the liver, peritoneum, abdominal and supra‐diaphragmatic lymph nodes.
Conclusion
18F‐FDOPA PET/CT seems not inferior than 68Ga‐DOTATOC PET/CT for the delineation of metastatic spread of ileal NETs. Therefore, according to local expertise and technical availability, 18F‐FDOPA should be considered as a valid clinical diagnostic option for exhaustive metastatic assessment in patients with ileal NETs. Obviously, 68Ga‐DOTATOC PET/CT remains mandatory for PRRT assessment. Further comparative studies are needed to determine the optimal approach in various clinical scenarios such as preoperative staging and primary tumour detection.</abstract><cop>Oxford</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/cen.14312</doi><tpages>8</tpages></addata></record> |
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| subjects | 18F‐FDOPA 68Ga‐DOTATOC carcinoid Computed tomography Lesions Lymph nodes Metastases Metastasis Neuroendocrine tumors neuroendocrine tumours Patients Peritoneum Positron emission tomography small‐intestine Tomography |
| title | Intraindividual comparison of 18F‐FDOPA and 68Ga‐DOTATOC PET/CT detection rate for metastatic assessment in patients with ileal neuroendocrine tumours |
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