Tailoring the radiotherapy approach in patients with anal squamous cell carcinoma based on inguinal sentinel lymph node biopsy
Background and Objectives The aim of our study was to analyze the results of selective inguinal node irradiation in patients with anal cancer, based on the biopsy of the inguinal sentinel lymph node (SLN), in terms of local control and prognosis. Methods Records of patients with anal squamous cell c...
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| Veröffentlicht in: | Journal of surgical oncology 2021-01, Vol.123 (1), p.315-321 |
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| creator | De Nardi, Paola Mistrangelo, Massimiliano Burtulo, Giovanni Passoni, Paolo Slim, Najla Ronzoni, Monica Canevari, Carla Parolini, Danilo Massimino, Luca Franco, Pierfrancesco Cassoni, Paola Lesca, Adriana Testa, Valentina Rosati, Riccardo |
| description | Background and Objectives
The aim of our study was to analyze the results of selective inguinal node irradiation in patients with anal cancer, based on the biopsy of the inguinal sentinel lymph node (SLN), in terms of local control and prognosis.
Methods
Records of patients with anal squamous cell carcinoma from January 2001 to December 2016 were retrospectively reviewed. Tc99 lymphoscintigraphy was performed in all the clinically inguinal negative patients, followed by radio‐guided surgical removal of the inguinal SLN. All patients were treated with combined radiochemotherapy. In patients with negative sentinel nodes, the inguinal area was excluded in the radiotherapy field.
Results
A total of 123 patients, 76 females (61.8%), mean age 60.1 ± 12.19 years old, underwent intraoperative lymph node retrieval. The histological analysis showed metastasis in the SLN in 28 patients (22.8%). The mean follow‐up was 43.44 ± 31.86 months. No inguinal recurrence was observed in patients with negative inguinal sentinel node(s). A statistically significant difference was observed for overall and disease‐free survivals in a patient with positive and negative inguinal sentinel nodes.
Conclusions
In patients with anal canal cancer, the exclusion of the inguinal regions from the radiotherapy field, in patients with negative SLN, does not compromise locoregional control nor prognosis. |
| doi_str_mv | 10.1002/jso.26226 |
| format | Article |
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The aim of our study was to analyze the results of selective inguinal node irradiation in patients with anal cancer, based on the biopsy of the inguinal sentinel lymph node (SLN), in terms of local control and prognosis.
Methods
Records of patients with anal squamous cell carcinoma from January 2001 to December 2016 were retrospectively reviewed. Tc99 lymphoscintigraphy was performed in all the clinically inguinal negative patients, followed by radio‐guided surgical removal of the inguinal SLN. All patients were treated with combined radiochemotherapy. In patients with negative sentinel nodes, the inguinal area was excluded in the radiotherapy field.
Results
A total of 123 patients, 76 females (61.8%), mean age 60.1 ± 12.19 years old, underwent intraoperative lymph node retrieval. The histological analysis showed metastasis in the SLN in 28 patients (22.8%). The mean follow‐up was 43.44 ± 31.86 months. No inguinal recurrence was observed in patients with negative inguinal sentinel node(s). A statistically significant difference was observed for overall and disease‐free survivals in a patient with positive and negative inguinal sentinel nodes.
Conclusions
In patients with anal canal cancer, the exclusion of the inguinal regions from the radiotherapy field, in patients with negative SLN, does not compromise locoregional control nor prognosis.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.26226</identifier><identifier>PMID: 32964456</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Anal cancer ; Anus ; Anus Neoplasms - mortality ; Anus Neoplasms - pathology ; Anus Neoplasms - radiotherapy ; Biopsy ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Colorectal cancer ; Female ; Humans ; Inguinal Canal - pathology ; inguinal radiotherapy ; inguinal recurrence ; inguinal sentinel node biopsy ; Lymphatic Metastasis ; Lymphatic system ; lymphoscintigraphy ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Radiation therapy ; Radiotherapy, Intensity-Modulated ; Retrospective Studies ; Sentinel Lymph Node Biopsy - methods ; Squamous cell carcinoma</subject><ispartof>Journal of surgical oncology, 2021-01, Vol.123 (1), p.315-321</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-d4309bb73a83b0de91cb4a16403cc46ab5ca89ab4d319c3ee74e6d23040f4b043</citedby><cites>FETCH-LOGICAL-c3536-d4309bb73a83b0de91cb4a16403cc46ab5ca89ab4d319c3ee74e6d23040f4b043</cites><orcidid>0000-0003-3975-9148 ; 0000-0002-2608-5749 ; 0000-0003-2276-0687 ; 0000-0002-2845-275X ; 0000-0003-1151-654X ; 0000-0001-8506-6794 ; 0000-0001-9447-3009 ; 0000-0002-8417-853X ; 0000-0001-8345-6537 ; 0000-0002-9337-6765 ; 0000-0003-1977-7410 ; 0000-0002-1975-9768 ; 0000-0002-7610-4848</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.26226$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.26226$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32964456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Nardi, Paola</creatorcontrib><creatorcontrib>Mistrangelo, Massimiliano</creatorcontrib><creatorcontrib>Burtulo, Giovanni</creatorcontrib><creatorcontrib>Passoni, Paolo</creatorcontrib><creatorcontrib>Slim, Najla</creatorcontrib><creatorcontrib>Ronzoni, Monica</creatorcontrib><creatorcontrib>Canevari, Carla</creatorcontrib><creatorcontrib>Parolini, Danilo</creatorcontrib><creatorcontrib>Massimino, Luca</creatorcontrib><creatorcontrib>Franco, Pierfrancesco</creatorcontrib><creatorcontrib>Cassoni, Paola</creatorcontrib><creatorcontrib>Lesca, Adriana</creatorcontrib><creatorcontrib>Testa, Valentina</creatorcontrib><creatorcontrib>Rosati, Riccardo</creatorcontrib><title>Tailoring the radiotherapy approach in patients with anal squamous cell carcinoma based on inguinal sentinel lymph node biopsy</title><title>Journal of surgical oncology</title><addtitle>J Surg Oncol</addtitle><description>Background and Objectives
The aim of our study was to analyze the results of selective inguinal node irradiation in patients with anal cancer, based on the biopsy of the inguinal sentinel lymph node (SLN), in terms of local control and prognosis.
Methods
Records of patients with anal squamous cell carcinoma from January 2001 to December 2016 were retrospectively reviewed. Tc99 lymphoscintigraphy was performed in all the clinically inguinal negative patients, followed by radio‐guided surgical removal of the inguinal SLN. All patients were treated with combined radiochemotherapy. In patients with negative sentinel nodes, the inguinal area was excluded in the radiotherapy field.
Results
A total of 123 patients, 76 females (61.8%), mean age 60.1 ± 12.19 years old, underwent intraoperative lymph node retrieval. The histological analysis showed metastasis in the SLN in 28 patients (22.8%). The mean follow‐up was 43.44 ± 31.86 months. No inguinal recurrence was observed in patients with negative inguinal sentinel node(s). A statistically significant difference was observed for overall and disease‐free survivals in a patient with positive and negative inguinal sentinel nodes.
Conclusions
In patients with anal canal cancer, the exclusion of the inguinal regions from the radiotherapy field, in patients with negative SLN, does not compromise locoregional control nor prognosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Anal cancer</subject><subject>Anus</subject><subject>Anus Neoplasms - mortality</subject><subject>Anus Neoplasms - pathology</subject><subject>Anus Neoplasms - radiotherapy</subject><subject>Biopsy</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Colorectal cancer</subject><subject>Female</subject><subject>Humans</subject><subject>Inguinal Canal - pathology</subject><subject>inguinal radiotherapy</subject><subject>inguinal recurrence</subject><subject>inguinal sentinel node biopsy</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>lymphoscintigraphy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Radiation therapy</subject><subject>Radiotherapy, Intensity-Modulated</subject><subject>Retrospective Studies</subject><subject>Sentinel Lymph Node Biopsy - methods</subject><subject>Squamous cell carcinoma</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPwzAQhC0EoqVw4A8gS5w4hPpVpz4ixFNIPQDnaO24raskTu1EVS78dgwFbpxmpf1mtDsInVNyTQlh003010wyJg_QmBIlM0XU_BCN045lIldkhE5i3BBClJLiGI04Sypmcow-3sBVPrhmhbu1xQFK59MQoB0wtG3wYNbYNbiFztmmi3jnujWGBioctz3Uvo_Y2KrCBoJxja8Ba4i2xL5JtlXvvsnkdI2tcDXU7Ro3vrRYO9_G4RQdLaGK9uxHJ-j9_u7t9jF7WTw83d68ZIbPuMxKwYnSOucw55qUVlGjBVApCDdGSNAzA3MFWpScKsOtzYWVJeNEkKXQRPAJutznpo-2vY1dsfF9SLfFgomc5TmdUZmoqz1lgo8x2GXRBldDGApKiq-mi9R08d10Yi9-Entd2_KP_K02AdM9sHOVHf5PKp5fF_vIT3Ijiko</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>De Nardi, Paola</creator><creator>Mistrangelo, Massimiliano</creator><creator>Burtulo, Giovanni</creator><creator>Passoni, Paolo</creator><creator>Slim, Najla</creator><creator>Ronzoni, Monica</creator><creator>Canevari, Carla</creator><creator>Parolini, Danilo</creator><creator>Massimino, Luca</creator><creator>Franco, Pierfrancesco</creator><creator>Cassoni, Paola</creator><creator>Lesca, Adriana</creator><creator>Testa, Valentina</creator><creator>Rosati, Riccardo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-3975-9148</orcidid><orcidid>https://orcid.org/0000-0002-2608-5749</orcidid><orcidid>https://orcid.org/0000-0003-2276-0687</orcidid><orcidid>https://orcid.org/0000-0002-2845-275X</orcidid><orcidid>https://orcid.org/0000-0003-1151-654X</orcidid><orcidid>https://orcid.org/0000-0001-8506-6794</orcidid><orcidid>https://orcid.org/0000-0001-9447-3009</orcidid><orcidid>https://orcid.org/0000-0002-8417-853X</orcidid><orcidid>https://orcid.org/0000-0001-8345-6537</orcidid><orcidid>https://orcid.org/0000-0002-9337-6765</orcidid><orcidid>https://orcid.org/0000-0003-1977-7410</orcidid><orcidid>https://orcid.org/0000-0002-1975-9768</orcidid><orcidid>https://orcid.org/0000-0002-7610-4848</orcidid></search><sort><creationdate>202101</creationdate><title>Tailoring the radiotherapy approach in patients with anal squamous cell carcinoma based on inguinal sentinel lymph node biopsy</title><author>De Nardi, Paola ; Mistrangelo, Massimiliano ; Burtulo, Giovanni ; Passoni, Paolo ; Slim, Najla ; Ronzoni, Monica ; Canevari, Carla ; Parolini, Danilo ; Massimino, Luca ; Franco, Pierfrancesco ; Cassoni, Paola ; Lesca, Adriana ; Testa, Valentina ; Rosati, Riccardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-d4309bb73a83b0de91cb4a16403cc46ab5ca89ab4d319c3ee74e6d23040f4b043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anal cancer</topic><topic>Anus</topic><topic>Anus Neoplasms - mortality</topic><topic>Anus Neoplasms - pathology</topic><topic>Anus Neoplasms - radiotherapy</topic><topic>Biopsy</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Colorectal cancer</topic><topic>Female</topic><topic>Humans</topic><topic>Inguinal Canal - pathology</topic><topic>inguinal radiotherapy</topic><topic>inguinal recurrence</topic><topic>inguinal sentinel node biopsy</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>lymphoscintigraphy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Radiation therapy</topic><topic>Radiotherapy, Intensity-Modulated</topic><topic>Retrospective Studies</topic><topic>Sentinel Lymph Node Biopsy - methods</topic><topic>Squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Nardi, Paola</creatorcontrib><creatorcontrib>Mistrangelo, Massimiliano</creatorcontrib><creatorcontrib>Burtulo, Giovanni</creatorcontrib><creatorcontrib>Passoni, Paolo</creatorcontrib><creatorcontrib>Slim, Najla</creatorcontrib><creatorcontrib>Ronzoni, Monica</creatorcontrib><creatorcontrib>Canevari, Carla</creatorcontrib><creatorcontrib>Parolini, Danilo</creatorcontrib><creatorcontrib>Massimino, Luca</creatorcontrib><creatorcontrib>Franco, Pierfrancesco</creatorcontrib><creatorcontrib>Cassoni, Paola</creatorcontrib><creatorcontrib>Lesca, Adriana</creatorcontrib><creatorcontrib>Testa, Valentina</creatorcontrib><creatorcontrib>Rosati, Riccardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Nardi, Paola</au><au>Mistrangelo, Massimiliano</au><au>Burtulo, Giovanni</au><au>Passoni, Paolo</au><au>Slim, Najla</au><au>Ronzoni, Monica</au><au>Canevari, Carla</au><au>Parolini, Danilo</au><au>Massimino, Luca</au><au>Franco, Pierfrancesco</au><au>Cassoni, Paola</au><au>Lesca, Adriana</au><au>Testa, Valentina</au><au>Rosati, Riccardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tailoring the radiotherapy approach in patients with anal squamous cell carcinoma based on inguinal sentinel lymph node biopsy</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J Surg Oncol</addtitle><date>2021-01</date><risdate>2021</risdate><volume>123</volume><issue>1</issue><spage>315</spage><epage>321</epage><pages>315-321</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
The aim of our study was to analyze the results of selective inguinal node irradiation in patients with anal cancer, based on the biopsy of the inguinal sentinel lymph node (SLN), in terms of local control and prognosis.
Methods
Records of patients with anal squamous cell carcinoma from January 2001 to December 2016 were retrospectively reviewed. Tc99 lymphoscintigraphy was performed in all the clinically inguinal negative patients, followed by radio‐guided surgical removal of the inguinal SLN. All patients were treated with combined radiochemotherapy. In patients with negative sentinel nodes, the inguinal area was excluded in the radiotherapy field.
Results
A total of 123 patients, 76 females (61.8%), mean age 60.1 ± 12.19 years old, underwent intraoperative lymph node retrieval. The histological analysis showed metastasis in the SLN in 28 patients (22.8%). The mean follow‐up was 43.44 ± 31.86 months. No inguinal recurrence was observed in patients with negative inguinal sentinel node(s). A statistically significant difference was observed for overall and disease‐free survivals in a patient with positive and negative inguinal sentinel nodes.
Conclusions
In patients with anal canal cancer, the exclusion of the inguinal regions from the radiotherapy field, in patients with negative SLN, does not compromise locoregional control nor prognosis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32964456</pmid><doi>10.1002/jso.26226</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3975-9148</orcidid><orcidid>https://orcid.org/0000-0002-2608-5749</orcidid><orcidid>https://orcid.org/0000-0003-2276-0687</orcidid><orcidid>https://orcid.org/0000-0002-2845-275X</orcidid><orcidid>https://orcid.org/0000-0003-1151-654X</orcidid><orcidid>https://orcid.org/0000-0001-8506-6794</orcidid><orcidid>https://orcid.org/0000-0001-9447-3009</orcidid><orcidid>https://orcid.org/0000-0002-8417-853X</orcidid><orcidid>https://orcid.org/0000-0001-8345-6537</orcidid><orcidid>https://orcid.org/0000-0002-9337-6765</orcidid><orcidid>https://orcid.org/0000-0003-1977-7410</orcidid><orcidid>https://orcid.org/0000-0002-1975-9768</orcidid><orcidid>https://orcid.org/0000-0002-7610-4848</orcidid></addata></record> |
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| ispartof | Journal of surgical oncology, 2021-01, Vol.123 (1), p.315-321 |
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| subjects | Adult Aged Anal cancer Anus Anus Neoplasms - mortality Anus Neoplasms - pathology Anus Neoplasms - radiotherapy Biopsy Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Colorectal cancer Female Humans Inguinal Canal - pathology inguinal radiotherapy inguinal recurrence inguinal sentinel node biopsy Lymphatic Metastasis Lymphatic system lymphoscintigraphy Male Middle Aged Neoplasm Recurrence, Local Radiation therapy Radiotherapy, Intensity-Modulated Retrospective Studies Sentinel Lymph Node Biopsy - methods Squamous cell carcinoma |
| title | Tailoring the radiotherapy approach in patients with anal squamous cell carcinoma based on inguinal sentinel lymph node biopsy |
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