Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patients with hematological cancer
The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immuno...
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| Veröffentlicht in: | International journal of hematology 2020-12, Vol.112 (6), p.851-859 |
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| container_title | International journal of hematology |
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| creator | Sogawa, Yuka Fukui, Makoto Nakamura, Shingen Sogabe, Kimiko Sumitani, Ryohei Yoshioka, Masami Abe, Masahiro Hinode, Daisuke |
| description | The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject were assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the Cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98,
p
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| doi_str_mv | 10.1007/s12185-020-02975-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2471929048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471929048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-653b0cb993a1d07d16a77d8fba09fb2c970394c5399040fd96498e6ba63b717b3</originalsourceid><addsrcrecordid>eNp9kUFvFSEUhUmjsa_VP9BFQ-J66gVmhmFpGqtNmripawIM9NG-gRGY177_4Q8WnVp3XdyQ3PudcxIOQmcELggA_5QJJUPXAIU6gnfN0xHakKHvGsZ5-wZtQNCu6TiBY3SS8z0A4dDyd-iY0WGAgbIN-nUd9nG3t5MNBUeHY1I7rJUpNnmFVRjXjZ-mJfhywCrj5PMDdhWJKWMXEzZbO8WytUnNh8aHcTF2xM7ubcKPvmxxsEtJcbahOvqAZ1V8TcvrsWpVibt4503NMSoYm96jt07tsv3w_J6iH1dfbi-_NTffv15ffr5pDOOiNH3HNBgtBFNkBD6SXnE-Dk4rEE5TIzgw0ZqOCQEtuFH0rRhsr1XPNCdcs1P0cfWdU_y52FzkfVxSqJGStpwIWnVDpehKmRRzTtbJOflJpYMkIP8UIdciZC1C_i1CPlXR-bP1oic7vkj-_XwF2Arkegp3Nv3PfsX2Nyrnl3A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471929048</pqid></control><display><type>article</type><title>Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patients with hematological cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Sogawa, Yuka ; Fukui, Makoto ; Nakamura, Shingen ; Sogabe, Kimiko ; Sumitani, Ryohei ; Yoshioka, Masami ; Abe, Masahiro ; Hinode, Daisuke</creator><creatorcontrib>Sogawa, Yuka ; Fukui, Makoto ; Nakamura, Shingen ; Sogabe, Kimiko ; Sumitani, Ryohei ; Yoshioka, Masami ; Abe, Masahiro ; Hinode, Daisuke</creatorcontrib><description>The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject were assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the Cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98,
p
< 0.05) and the rate of
Fusobacterium nucleatum
[
F. nucleatum
count per total bacterial count (%)] was high (HR 1.65,
p
< 0.05) in patients with FwN onset. Using ROC curve analysis, the optimal cutoff point based on the AUC in the
F. nucleatum
/sIgA ratio was 0.023, and this model had a 78.4% probability (
p
< 0.01). The risk of FwN onset was also significantly higher among the group of ≥ 0.023
F. nucleatum
/sIgA ratio (HR 66.06,
p
< 0.01). These results suggest that the rate of
F. nucleatum
and the levels of sIgA at baseline might be related to FwN onset as risk factors.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-020-02975-x</identifier><identifier>PMID: 32880823</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anaerobic bacteria ; Antineoplastic Agents - adverse effects ; Bacteria ; Bacterial Load ; Blood cancer ; Cancer ; Chemotherapy ; Febrile Neutropenia - etiology ; Female ; Fever ; Fusobacterium nucleatum - isolation & purification ; Hematologic Neoplasms - complications ; Hematologic Neoplasms - drug therapy ; Hematologic Neoplasms - immunology ; Hematologic Neoplasms - microbiology ; Hematology ; Humans ; Immunity ; Immunoglobulin A ; Immunoglobulin A, Secretory ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mouth - immunology ; Mouth - microbiology ; Neutropenia ; Oncology ; Original Article ; Risk analysis ; Risk Factors ; Saliva ; Statistical models ; Young Adult</subject><ispartof>International journal of hematology, 2020-12, Vol.112 (6), p.851-859</ispartof><rights>Japanese Society of Hematology 2020</rights><rights>Japanese Society of Hematology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c379t-653b0cb993a1d07d16a77d8fba09fb2c970394c5399040fd96498e6ba63b717b3</cites><orcidid>0000-0002-2202-5538</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-020-02975-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-020-02975-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32880823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sogawa, Yuka</creatorcontrib><creatorcontrib>Fukui, Makoto</creatorcontrib><creatorcontrib>Nakamura, Shingen</creatorcontrib><creatorcontrib>Sogabe, Kimiko</creatorcontrib><creatorcontrib>Sumitani, Ryohei</creatorcontrib><creatorcontrib>Yoshioka, Masami</creatorcontrib><creatorcontrib>Abe, Masahiro</creatorcontrib><creatorcontrib>Hinode, Daisuke</creatorcontrib><title>Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patients with hematological cancer</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject were assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the Cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98,
p
< 0.05) and the rate of
Fusobacterium nucleatum
[
F. nucleatum
count per total bacterial count (%)] was high (HR 1.65,
p
< 0.05) in patients with FwN onset. Using ROC curve analysis, the optimal cutoff point based on the AUC in the
F. nucleatum
/sIgA ratio was 0.023, and this model had a 78.4% probability (
p
< 0.01). The risk of FwN onset was also significantly higher among the group of ≥ 0.023
F. nucleatum
/sIgA ratio (HR 66.06,
p
< 0.01). These results suggest that the rate of
F. nucleatum
and the levels of sIgA at baseline might be related to FwN onset as risk factors.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anaerobic bacteria</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Bacteria</subject><subject>Bacterial Load</subject><subject>Blood cancer</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Febrile Neutropenia - etiology</subject><subject>Female</subject><subject>Fever</subject><subject>Fusobacterium nucleatum - isolation & purification</subject><subject>Hematologic Neoplasms - complications</subject><subject>Hematologic Neoplasms - drug therapy</subject><subject>Hematologic Neoplasms - immunology</subject><subject>Hematologic Neoplasms - microbiology</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin A, Secretory</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mouth - immunology</subject><subject>Mouth - microbiology</subject><subject>Neutropenia</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Saliva</subject><subject>Statistical models</subject><subject>Young Adult</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUFvFSEUhUmjsa_VP9BFQ-J66gVmhmFpGqtNmripawIM9NG-gRGY177_4Q8WnVp3XdyQ3PudcxIOQmcELggA_5QJJUPXAIU6gnfN0xHakKHvGsZ5-wZtQNCu6TiBY3SS8z0A4dDyd-iY0WGAgbIN-nUd9nG3t5MNBUeHY1I7rJUpNnmFVRjXjZ-mJfhywCrj5PMDdhWJKWMXEzZbO8WytUnNh8aHcTF2xM7ubcKPvmxxsEtJcbahOvqAZ1V8TcvrsWpVibt4503NMSoYm96jt07tsv3w_J6iH1dfbi-_NTffv15ffr5pDOOiNH3HNBgtBFNkBD6SXnE-Dk4rEE5TIzgw0ZqOCQEtuFH0rRhsr1XPNCdcs1P0cfWdU_y52FzkfVxSqJGStpwIWnVDpehKmRRzTtbJOflJpYMkIP8UIdciZC1C_i1CPlXR-bP1oic7vkj-_XwF2Arkegp3Nv3PfsX2Nyrnl3A</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Sogawa, Yuka</creator><creator>Fukui, Makoto</creator><creator>Nakamura, Shingen</creator><creator>Sogabe, Kimiko</creator><creator>Sumitani, Ryohei</creator><creator>Yoshioka, Masami</creator><creator>Abe, Masahiro</creator><creator>Hinode, Daisuke</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-2202-5538</orcidid></search><sort><creationdate>20201201</creationdate><title>Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patients with hematological cancer</title><author>Sogawa, Yuka ; Fukui, Makoto ; Nakamura, Shingen ; Sogabe, Kimiko ; Sumitani, Ryohei ; Yoshioka, Masami ; Abe, Masahiro ; Hinode, Daisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-653b0cb993a1d07d16a77d8fba09fb2c970394c5399040fd96498e6ba63b717b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anaerobic bacteria</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Bacteria</topic><topic>Bacterial Load</topic><topic>Blood cancer</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Febrile Neutropenia - etiology</topic><topic>Female</topic><topic>Fever</topic><topic>Fusobacterium nucleatum - isolation & purification</topic><topic>Hematologic Neoplasms - complications</topic><topic>Hematologic Neoplasms - drug therapy</topic><topic>Hematologic Neoplasms - immunology</topic><topic>Hematologic Neoplasms - microbiology</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin A, Secretory</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mouth - immunology</topic><topic>Mouth - microbiology</topic><topic>Neutropenia</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Saliva</topic><topic>Statistical models</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sogawa, Yuka</creatorcontrib><creatorcontrib>Fukui, Makoto</creatorcontrib><creatorcontrib>Nakamura, Shingen</creatorcontrib><creatorcontrib>Sogabe, Kimiko</creatorcontrib><creatorcontrib>Sumitani, Ryohei</creatorcontrib><creatorcontrib>Yoshioka, Masami</creatorcontrib><creatorcontrib>Abe, Masahiro</creatorcontrib><creatorcontrib>Hinode, Daisuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sogawa, Yuka</au><au>Fukui, Makoto</au><au>Nakamura, Shingen</au><au>Sogabe, Kimiko</au><au>Sumitani, Ryohei</au><au>Yoshioka, Masami</au><au>Abe, Masahiro</au><au>Hinode, Daisuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patients with hematological cancer</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>112</volume><issue>6</issue><spage>851</spage><epage>859</epage><pages>851-859</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject were assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the Cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98,
p
< 0.05) and the rate of
Fusobacterium nucleatum
[
F. nucleatum
count per total bacterial count (%)] was high (HR 1.65,
p
< 0.05) in patients with FwN onset. Using ROC curve analysis, the optimal cutoff point based on the AUC in the
F. nucleatum
/sIgA ratio was 0.023, and this model had a 78.4% probability (
p
< 0.01). The risk of FwN onset was also significantly higher among the group of ≥ 0.023
F. nucleatum
/sIgA ratio (HR 66.06,
p
< 0.01). These results suggest that the rate of
F. nucleatum
and the levels of sIgA at baseline might be related to FwN onset as risk factors.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32880823</pmid><doi>10.1007/s12185-020-02975-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2202-5538</orcidid></addata></record> |
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| ispartof | International journal of hematology, 2020-12, Vol.112 (6), p.851-859 |
| issn | 0925-5710 1865-3774 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Anaerobic bacteria Antineoplastic Agents - adverse effects Bacteria Bacterial Load Blood cancer Cancer Chemotherapy Febrile Neutropenia - etiology Female Fever Fusobacterium nucleatum - isolation & purification Hematologic Neoplasms - complications Hematologic Neoplasms - drug therapy Hematologic Neoplasms - immunology Hematologic Neoplasms - microbiology Hematology Humans Immunity Immunoglobulin A Immunoglobulin A, Secretory Male Medicine Medicine & Public Health Middle Aged Mouth - immunology Mouth - microbiology Neutropenia Oncology Original Article Risk analysis Risk Factors Saliva Statistical models Young Adult |
| title | Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patients with hematological cancer |
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