Multifaceted behavior of PEST sequence enriched nuclear proteins in cancer biology and role in gene therapy

The amino acid sequence enriched with proline (P), glutamic acid (E), serine (S), and threonine (T) (PEST) is a signal‐transducing agent providing unique features to its substrate nuclear proteins (PEST‐NPs). The PEST motif is responsible for particular posttranslational modifications (PTMs). These...

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Veröffentlicht in:	Journal of cellular physiology 2021-03, Vol.236 (3), p.1658-1676
Hauptverfasser:	Sarfraz, Muhammad, Afzal, Attia, Khattak, Saadullah, Saddozai, Umair A. K., Li, Hui‐Min, Zhang, Qian‐Qian, Madni, Asadullah, Haleem, Kashif S., Duan, Shao‐Feng, Wu, Dong‐Dong, Ji, Shao‐Ping, Ji, Xin‐Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acids Biology Cancer cancer biology Gene therapy Glutamic acid Localization nuclear proteins PEST sequence Pests posttranslational modifications Proline Protein interaction Protein turnover Proteins protein–protein interactions Serine Substrates Suppressors Threonine Transcription Tumors
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