ALK‐positive compound Spitz nevus with extensive perineural and intraneural neurotropism
Historically recognized by their characteristic histopathologic features, Spitz neoplasms are now known to be molecularly defined by mutually exclusive recurrent abnormalities that cause activation of the MAPK pathway. Spitz neoplasms with ALK rearrangements frequently demonstrate polypoid growth wi...
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| Veröffentlicht in: | Journal of cutaneous pathology 2021-01, Vol.48 (1), p.154-159 |
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| container_title | Journal of cutaneous pathology |
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| creator | Brown, Ryanne A. Wang, Jennifer Y. Raghavan, Shyam S. Zhang, Jingjing Wan, Derrick C. Born, Donald Koo, Matthew Hazard, Florette K. Novoa, Roberto A. Rieger, Kerri E. |
| description | Historically recognized by their characteristic histopathologic features, Spitz neoplasms are now known to be molecularly defined by mutually exclusive recurrent abnormalities that cause activation of the MAPK pathway. Spitz neoplasms with ALK rearrangements frequently demonstrate polypoid growth with a plexiform arrangement of nested, fusiform melanocytes in intersecting fascicles. Although neurotropism has been described in indolent Spitz neoplasms, this feature is not frequently mentioned in publications on histopathologic assessment of this group of melanocytic tumors. Here, we present an unusual case of a 3‐year‐old female with an ALK‐positive compound Spitz nevus with extensive perineural and intraneural neurotropism occurring on the vermilion border of the lower lip. |
| doi_str_mv | 10.1111/cup.13890 |
| format | Article |
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Spitz neoplasms with ALK rearrangements frequently demonstrate polypoid growth with a plexiform arrangement of nested, fusiform melanocytes in intersecting fascicles. Although neurotropism has been described in indolent Spitz neoplasms, this feature is not frequently mentioned in publications on histopathologic assessment of this group of melanocytic tumors. Here, we present an unusual case of a 3‐year‐old female with an ALK‐positive compound Spitz nevus with extensive perineural and intraneural neurotropism occurring on the vermilion border of the lower lip.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/cup.13890</identifier><identifier>PMID: 33034114</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>ALK ; MAP kinase ; Melanocytes ; Neoplasia ; neurotropism ; Nevus ; Spitz nevus ; Tumors</subject><ispartof>Journal of cutaneous pathology, 2021-01, Vol.48 (1), p.154-159</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3200-bded04ac225ac7451c1be1835e4bb55c366d3235d83a486e9b120f0222fa8d343</citedby><cites>FETCH-LOGICAL-c3200-bded04ac225ac7451c1be1835e4bb55c366d3235d83a486e9b120f0222fa8d343</cites><orcidid>0000-0002-3816-1542 ; 0000-0002-2537-1081 ; 0000-0001-9099-7227 ; 0000-0002-4436-2471</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcup.13890$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcup.13890$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33034114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, Ryanne A.</creatorcontrib><creatorcontrib>Wang, Jennifer Y.</creatorcontrib><creatorcontrib>Raghavan, Shyam S.</creatorcontrib><creatorcontrib>Zhang, Jingjing</creatorcontrib><creatorcontrib>Wan, Derrick C.</creatorcontrib><creatorcontrib>Born, Donald</creatorcontrib><creatorcontrib>Koo, Matthew</creatorcontrib><creatorcontrib>Hazard, Florette K.</creatorcontrib><creatorcontrib>Novoa, Roberto A.</creatorcontrib><creatorcontrib>Rieger, Kerri E.</creatorcontrib><title>ALK‐positive compound Spitz nevus with extensive perineural and intraneural neurotropism</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>Historically recognized by their characteristic histopathologic features, Spitz neoplasms are now known to be molecularly defined by mutually exclusive recurrent abnormalities that cause activation of the MAPK pathway. Spitz neoplasms with ALK rearrangements frequently demonstrate polypoid growth with a plexiform arrangement of nested, fusiform melanocytes in intersecting fascicles. Although neurotropism has been described in indolent Spitz neoplasms, this feature is not frequently mentioned in publications on histopathologic assessment of this group of melanocytic tumors. Here, we present an unusual case of a 3‐year‐old female with an ALK‐positive compound Spitz nevus with extensive perineural and intraneural neurotropism occurring on the vermilion border of the lower lip.</description><subject>ALK</subject><subject>MAP kinase</subject><subject>Melanocytes</subject><subject>Neoplasia</subject><subject>neurotropism</subject><subject>Nevus</subject><subject>Spitz nevus</subject><subject>Tumors</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kEtOwzAQhi0EoqWw4AIoEisWaf1OuqwqXqISSNANG8txHOGqTYydtJQVR-CMnASHFHbMZjSaT_-MPgBOERyiUCPV2CEi6RjugT7iEMaQcbgP-pBAEvNxmvTAkfcLCBFPOTsEPRIWFCHaB8-T2d3Xx6etvKnNWkeqWtmqKfPo0Zr6PSr1uvHRxtQvkX6rdelbxmpnSt04uYxkIE1ZO7mb21bVrrLGr47BQSGXXp_s-gDMry6fpjfx7P76djqZxYrg8GuW6xxSqTBmUiWUIYUyjVLCNM0yxhThPCeYsDwlkqZcjzOEYQExxoVMc0LJAJx3udZVr432tVhUjSvDSYFpghLIGGupi45SrvLe6UJYZ1bSbQWCorUogkXxYzGwZ7vEJlvp_I_81RaAUQdszFJv_08S0_lDF_kNDgV9rQ</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Brown, Ryanne A.</creator><creator>Wang, Jennifer Y.</creator><creator>Raghavan, Shyam S.</creator><creator>Zhang, Jingjing</creator><creator>Wan, Derrick C.</creator><creator>Born, Donald</creator><creator>Koo, Matthew</creator><creator>Hazard, Florette K.</creator><creator>Novoa, Roberto A.</creator><creator>Rieger, Kerri E.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0002-3816-1542</orcidid><orcidid>https://orcid.org/0000-0002-2537-1081</orcidid><orcidid>https://orcid.org/0000-0001-9099-7227</orcidid><orcidid>https://orcid.org/0000-0002-4436-2471</orcidid></search><sort><creationdate>202101</creationdate><title>ALK‐positive compound Spitz nevus with extensive perineural and intraneural neurotropism</title><author>Brown, Ryanne A. ; Wang, Jennifer Y. ; Raghavan, Shyam S. ; Zhang, Jingjing ; Wan, Derrick C. ; Born, Donald ; Koo, Matthew ; Hazard, Florette K. ; Novoa, Roberto A. ; Rieger, Kerri E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3200-bded04ac225ac7451c1be1835e4bb55c366d3235d83a486e9b120f0222fa8d343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>ALK</topic><topic>MAP kinase</topic><topic>Melanocytes</topic><topic>Neoplasia</topic><topic>neurotropism</topic><topic>Nevus</topic><topic>Spitz nevus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, Ryanne A.</creatorcontrib><creatorcontrib>Wang, Jennifer Y.</creatorcontrib><creatorcontrib>Raghavan, Shyam S.</creatorcontrib><creatorcontrib>Zhang, Jingjing</creatorcontrib><creatorcontrib>Wan, Derrick C.</creatorcontrib><creatorcontrib>Born, Donald</creatorcontrib><creatorcontrib>Koo, Matthew</creatorcontrib><creatorcontrib>Hazard, Florette K.</creatorcontrib><creatorcontrib>Novoa, Roberto A.</creatorcontrib><creatorcontrib>Rieger, Kerri E.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, Ryanne A.</au><au>Wang, Jennifer Y.</au><au>Raghavan, Shyam S.</au><au>Zhang, Jingjing</au><au>Wan, Derrick C.</au><au>Born, Donald</au><au>Koo, Matthew</au><au>Hazard, Florette K.</au><au>Novoa, Roberto A.</au><au>Rieger, Kerri E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ALK‐positive compound Spitz nevus with extensive perineural and intraneural neurotropism</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2021-01</date><risdate>2021</risdate><volume>48</volume><issue>1</issue><spage>154</spage><epage>159</epage><pages>154-159</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><abstract>Historically recognized by their characteristic histopathologic features, Spitz neoplasms are now known to be molecularly defined by mutually exclusive recurrent abnormalities that cause activation of the MAPK pathway. Spitz neoplasms with ALK rearrangements frequently demonstrate polypoid growth with a plexiform arrangement of nested, fusiform melanocytes in intersecting fascicles. Although neurotropism has been described in indolent Spitz neoplasms, this feature is not frequently mentioned in publications on histopathologic assessment of this group of melanocytic tumors. Here, we present an unusual case of a 3‐year‐old female with an ALK‐positive compound Spitz nevus with extensive perineural and intraneural neurotropism occurring on the vermilion border of the lower lip.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>33034114</pmid><doi>10.1111/cup.13890</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3816-1542</orcidid><orcidid>https://orcid.org/0000-0002-2537-1081</orcidid><orcidid>https://orcid.org/0000-0001-9099-7227</orcidid><orcidid>https://orcid.org/0000-0002-4436-2471</orcidid></addata></record> |
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| language | eng |
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| source | Wiley Journals |
| subjects | ALK MAP kinase Melanocytes Neoplasia neurotropism Nevus Spitz nevus Tumors |
| title | ALK‐positive compound Spitz nevus with extensive perineural and intraneural neurotropism |
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