IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis

Objective To investigate the role of IL-33 in gouty arthritis. Material 174 Balb/c (wild-type) and 54 ST2 −/− mice were used in this study. In vitro experiments were conducted in bone marrow-derived macrophages (BMDMs). Synovial fluid samples from gouty arthritis ( n = 7) and osteoarthritis ( n = ...

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Veröffentlicht in:	Inflammation research 2020-12, Vol.69 (12), p.1271-1282
Hauptverfasser:	Fattori, Victor, Staurengo-Ferrari, Larissa, Zaninelli, Tiago H., Casagrande, Rubia, Oliveira, Rene D., Louzada-Junior, Paulo, Cunha, Thiago M., Alves-Filho, Jose C., Teixeira, Mauro M., Cunha, Fernando Q., Amaral, Flavio A., Verri, Waldiceu A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Animals Arthritis Arthritis, Gouty - chemically induced Arthritis, Gouty - metabolism Arthritis, Gouty - pathology Biomedical and Life Sciences Biomedical materials Biomedicine Bone marrow Crystals Cytokines Dermatology Edema Female Gout Humans IL-1β Immunology Inflammation - chemically induced Inflammation - psychology Interleukin-1 Receptor-Like 1 Protein - genetics Interleukin-1beta - metabolism Interleukin-33 - pharmacology Joints (anatomy) Knee Macrophages Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred BALB C Mice, Knockout Middle Aged Neurology Neutrophil Infiltration - drug effects Neutrophils Original Research Paper Osteoarthritis Pain Pain - chemically induced Pain - psychology Peroxidase - metabolism Pharmacology/Toxicology Priming Recruitment Rheumatism Rheumatology Staining Superoxide anions Superoxides - metabolism Synovial fluid Synovial Membrane - pathology Tumor necrosis factor-α Uric Acid
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