Synthesis and in vitro study of new coumarin derivatives linked to nicotinonitrile moieties as potential acetylcholinesterase inhibitors

The appropriate pyridine‐2(1H)‐thiones were reacted with an equivalent amount of 5‐(chloromethyl)‐2‐hydroxybenzaldehyde in ethanol in the presence of potassium hydroxide to give the corresponding 2‐hydroxybenzaldehyde derivatives in excellent yields. The latter derivatives were taken as key synthons...

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Veröffentlicht in:	Journal of heterocyclic chemistry 2020-12, Vol.57 (12), p.4278-4290
Hauptverfasser:	Mekky, Ahmed E. M., Sanad, Sherif M. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Coumarin Cytotoxicity Derivatives Ethanol Free radicals Hydroxybenzaldehydes Potassium hydroxides Scavenging Sodium acetate Toxicity
Online-Zugang:	Volltext
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