Geraniol ameliorates diabetic nephropathy via interference with miRNA-21/PTEN/Akt/mTORC1 pathway in rats

Deregulated activity of protein kinase B/mammalian target of rapamycin complex-1 (Akt/mTORC1) incites crucial pathological characteristics of diabetic nephropathy. The acyclic monoterpene geraniol has been recently reported to possess antidiabetic effects; however, its potential renoprotective effec...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2020-12, Vol.393 (12), p.2325-2337
Hauptverfasser:	El-Said, Yasmin Ahmed Mohamed, Sallam, Nada Abdelmoneim Abdelhalium, Ain-Shoka, Afaf Abdel-Moniem, Abdel-Latif, Hekma Abdel-Tawab
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine AKT protein Antidiabetics Antioxidants Biomedical and Life Sciences Biomedicine Cell proliferation Creatinine Diabetes Diabetes mellitus Diabetic nephropathy Extracellular matrix Kinases Lipid peroxidation Matrix protein miRNA Nephropathy Neurosciences Nicotine Original Article Pharmacology/Toxicology Protein biosynthesis Protein phosphatase Proteins PTEN protein Rapamycin Renal function Streptozocin Superoxide dismutase TOR protein Transforming growth factor-b Tumor suppressor genes Urea
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