Benzoyl-CoA conjugate accumulation as an initiating event for male reprotoxic effects in the rat? Structure–activity analysis, species specificity, and in vivo relevance

A number of para -substituted benzoic acids ( p -BA) and chemicals metabolized to p -BA have been found to confer adverse effects in male rats on sperm viability, motility, and morphology. These effects are putatively associated with the metabolism of p -BA to toxic intermediates. We had shown that...

Ausführliche Beschreibung