Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles

The systemic biodistribution of endogenous extracellular vesicles is central to the maintenance of tissue homeostasis. Here, we show that angiogenesis and heart function in infarcted heart tissue can be ameliorated by the local accumulation of exosomes collected from circulation using magnetic nanop...

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Veröffentlicht in:	Nature biomedical engineering 2020-11, Vol.4 (11), p.1063-1075
Hauptverfasser:	Liu, Shiyu, Chen, Xin, Bao, Lili, Liu, Tao, Yuan, Pingyun, Yang, Xiaoshan, Qiu, Xinyu, Gooding, J. Justin, Bai, Yongkang, Xiao, Jiajia, Pu, Fengxing, Jin, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	13/107 631/61/350/354 631/61/54/990 Accumulation Angiogenesis Animal models Animals Antibodies Antibodies - administration & dosage Antibodies - chemistry Antigens Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Cardiomyocytes CD63 antigen Drug Delivery Systems - methods Ethylene glycol Exosomes Exosomes - chemistry Female Heart Heart - drug effects Heart attacks Heart function Homeostasis Hydrazones Iron oxides Magnetic Iron Oxide Nanoparticles - administration & dosage Magnetic Iron Oxide Nanoparticles - chemistry Materials Testing Myocardial infarction Myocardial Infarction - prevention & control Myosin Nanoparticles Neovascularization, Pathologic - prevention & control Polyethylene glycol Rats, Sprague-Dawley Silicon dioxide Surface markers Tissue Distribution Ventricle Vesicles
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